Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 692-698

  Choi, Min Jung ^a   Park, Eun Jung ^a   Min, Kyoung Jin ^a   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

Author keywords

Apoptosis; CHOP; Endoplasmic reticulum stress; Unfolded protein response; Withaferin A

Indexed keywords

CASPASE 4; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN HOMOLOGOUS PROTEIN; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WITHAFERIN A; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PROTEIN PHOSPHORYLATION; RNA SPLICING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, RENAL CELL; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM, ROUGH; GENE SILENCING; HT29 CELLS; HUMANS; KIDNEY NEOPLASMS; OXIDATIVE STRESS; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; WITHANOLIDES;

EUKARYOTA; WITHANIA SOMNIFERA;

EID: 79952042622     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.010     Document Type: Article

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