Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 9145-9152

  Fricker, Michael ^a   Vilalta, Anna ^a   Tolkovsky, Aviva M ^b   Brown, Guy C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITORS; CELL TYPES; INFLAMMATORY STIMULI; LIPOTEICHOIC ACIDS; MICROGLIA; NEURONAL DEATH; NEURONAL LOSS; SPECIFIC INHIBITORS;

CELL DEATH;

NEURONS;

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; NECROSTATIN 1; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RECEPTOR INTERACTING PROTEIN KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; CELL KILLING; CELL LOSS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; MICROGLIA; NECROPTOSIS; NERVE CELL CULTURE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 8; CASPASE INHIBITORS; CELL SURVIVAL; CELLS, CULTURED; IMIDAZOLES; INDOLES; INFLAMMATION; LIPOPOLYSACCHARIDES; MICROGLIA; MODELS, BIOLOGICAL; NECROSIS; NEUROGLIA; NEURONS; RATS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84876001460     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427880     Document Type: Article

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