Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade

Apoptosis

Volumn 13, Issue 12, 2008, Pages 1450-1464

  Mandal, Chandan ^a   Dutta, Avijit ^a,b   Mallick, Asish ^a   Chandra, Sarmila ^c   Misra, Laxminarain ^d   Sangwan, Rajender S ^d   Mandal, Chitra ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c Kothari Medical Centre   (India)

^d CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

Activation of p38 MAPK; Acute lymphoblastic leukemia; Apoptosis; Mitochondrial death cascade; Myeloid leukemia; Transcription factors; Withaferin A

Indexed keywords

CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; WITHAFERIN A;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MITOCHONDRION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WITHANIA SOMNIFERA;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ERGOSTEROL; HUMANS; LEUKEMIA; MAP KINASE SIGNALING SYSTEM; MEDICINE, TRADITIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLANTS, MEDICINAL; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

WITHANIA SOMNIFERA;

EID: 56349141560     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0271-0     Document Type: Article

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