Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Vaishnavi, Kirti ^a   Saxena, Nishant ^b,c   Shah, Navjot ^b,c   Singh, Rumani ^b,c   Manjunath, Kavyashree ^a   Uthayakumar, M ^a   Kanaujia, Shankar P ^a   Kaul, Sunil C ^b   Sekar, Kanagaraj ^a   Wadhwa, Renu ^b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; PROTEIN P21; PROTEIN P53; RIBOZYME; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; WITHAFERIN A; WITHANOLIDE; WITHANONE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOINFORMATICS; CANCER CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; EXPERIMENTAL STUDY; FIBROBLAST; GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MOLECULAR DOCKING; MORTALIN GENE; NRF2 GENE; OSTEOSARCOMA CELL; P21 GENE; P53 GENE; PHYTOCHEMISTRY;

BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; MEDICINE, AYURVEDIC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; PLANT EXTRACTS; PLANT LEAVES; TETRAZOLIUM SALTS; THIAZOLES; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53; WITHANIA; WITHANOLIDES;

WITHANIA SOMNIFERA;

EID: 84866014725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044419     Document Type: Article

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