Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Priyandoko, Didik ^a,b   Ishii, Tetsuro ^b   Kaul, Sunil C ^a   Wadhwa, Renu ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHOXYACETIC ACID; PHTHALIC ACID; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; WITHANIA SOMNIFERA EXTRACT; 6,7 EPOXY 5,17 DIHYDROXY 1 OXOWITHA 2,24 DIENOLIDE; 6,7-EPOXY-5,17-DIHYDROXY-1-OXOWITHA-2,24-DIENOLIDE; ACETIC ACID DERIVATIVE; ANTIOXIDANT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; NFE2L2 PROTEIN, HUMAN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRITERPENE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; HUMAN; HUMAN CELL; MITOCHONDRION; PHYTOCHEMISTRY; PLANT LEAF; PROTEIN DEGRADATION; SENESCENCE; SIGNAL TRANSDUCTION; WITHANIA SOMNIFERA; CELL AGING; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; FIBROBLAST; GENETICS; INDUSTRY; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; WITHANIA;

WITHANIA SOMNIFERA;

ACETIC ACIDS; ANTIOXIDANTS; CELL AGING; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOPROTECTION; DNA DAMAGE; FIBROBLASTS; HUMANS; INDUSTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; PLANT LEAVES; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53; WITHANIA;

EID: 79955780639     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019552     Document Type: Article

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