Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 8, 2011, Pages 4288-4293

  Chiu, Chien Chih ^a   Liu, Po Len ^b   Huang, Kuang Jing ^c   Wang, Hui Min ^a   Chang, Kuo Feng ^a   Chou, Chon Kit ^a   Chang, Fang Rong ^a   Chong, Inn Wen ^c   Fang, Kang ^d   Chen, Jia Shing ^e   Chang, Hsueh Wei ^a,c   Wu, Yang Chang ^a,f  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

cell migration; comet assay; Goniothalamin; matrix metalloproteinase; non small cell lung cancer

Indexed keywords

CELL MIGRATION; COMET ASSAY; GONIOTHALAMIN; MATRIX METALLOPROTEINASE; NON SMALL CELL LUNG CANCER;

ASSAYS; BIOLOGICAL ORGANS; BLOOD VESSELS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; DNA; ENZYME INHIBITION; NUCLEIC ACIDS;

DISEASES;

ANTINEOPLASTIC AGENT; GONIOTHALAMIN; PYRONE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DIVISION; CELL MOTION; COMET ASSAY; DNA DAMAGE; DRUG EFFECT; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; CELL LINE, TUMOR; CELL MOVEMENT; COMET ASSAY; DNA DAMAGE; HUMANS; LUNG NEOPLASMS; PYRONES;

EID: 79955033768     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf200566a     Document Type: Article

References (36)

1. Rossi, A.; Ricciardi, S.; Maione, P.; de Marinis, F.; Gridelli, C. Pemetrexed in the treatment of advanced non-squamous lung cancer Lung Cancer 2009, 66, 141-149
2. Schiller, J. H.; Harrington, D.; Belani, C. P.; Langer, C.; Sandler, A.; Krook, J.; Zhu, J.; Johnson, D. H. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer N. Engl. J. Med. 2002, 346, 92-98 (Pubitemid 34438899)
3. Lee, K. H. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach J. Nat. Prod. 2010, 73, 500-516
4. Liu, E. H.; Qi, L. W.; Wu, Q.; Peng, Y. B.; Li, P. Anticancer agents derived from natural products Mini-Rev. Med. Chem. 2009, 9, 1547-1555
5. 3-PPD Lung Cancer 2009, 65, 306-311
6. Blázquez, M. A.; Bermejo, A.; Zafra-Polo, M. C.; Cortes, D. Styryllactones from Goniothalamus species-A review Phytochem. Anal. 1999, 10, 161-170
7. Ali, A. M.; Mackeen, M. M.; Hamid, M.; Aun, Q. B.; Zauyah, Y.; Azimahtol, H. L.; Kawazu, K. Cytotoxicity and electron microscopy of cell death induced by goniothalamin Planta Med. 1997, 63, 81-83 (Pubitemid 27112447)
8. de Fatima, A.; Kohn, L. K.; Carvalho, J. E.; Pilli, R. A. Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells Bioorg. Med. Chem. 2006, 14, 622-631 (Pubitemid 41767566)
9. Fatima, A.; Kohn, L. K.; Carvalho, J. E.; Pilli, R. A. Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells Bioorg. Med. Chem. 2006, 14, 622-631 (Pubitemid 41767566)
10. Pihie, A. H.; Stanslas, J.; Din, L. B. Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines Anticancer Res. 1998, 18, 1739-1743 (Pubitemid 28342586)
11. Inayat-Hussain, S. H.; Annuar, B. O.; Din, L. B.; Ali, A. M.; Ross, D. Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells Toxicol. in Vitro 2003, 17, 433-439 (Pubitemid 36776785)
12. Inayat-Hussain, S. H.; Chan, K. M.; Rajab, N. F.; Din, L. B.; Chow, S. C.; Kizilors, A.; Farzaneh, F.; Williams, G. T. Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells Toxicol. Lett. 2010, 193, 108-114
13. Inayat-Hussain, S. H.; Osman, A. B.; Din, L. B.; Ali, A. M.; Snowden, R. T.; MacFarlane, M.; Cain, K. Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells FEBS Lett. 1999, 456, 379-383 (Pubitemid 29364298)
14. Inayat-Hussain, S. H.; Wong, L. T.; Chan, K. M.; Rajab, N. F.; Din, L. B.; Harun, R.; Kizilors, A.; Saxena, N.; Mourtada-Maarabouni, M.; Farzaneh, F.; Williams, G. T. RACK-1 overexpression protects against goniothalamin-induced cell death Toxicol. Lett. 2009, 191, 118-122
15. de Fatima, A.; Kohn, L. K.; Antonio, M. A.; de Carvalho, J. E.; Pilli, R. A. (R)-Goniothalamin: Total syntheses and cytotoxic activity against cancer cell lines Bioorg. Med. Chem. 2005, 13, 2927-2933 (Pubitemid 40392478)
16. Chan, K. M.; Rajab, N. F.; Ishak, M. H.; Ali, A. M.; Yusoff, K.; Din, L. B.; Inayat-Hussain, S. H. Goniothalamin induces apoptosis in vascular smooth muscle cells Chem.-Biol. Interact. 2006, 159, 129-140 (Pubitemid 43042620)
17. Chan, K. M.; Rajab, N. F.; Siegel, D.; Din, L. B.; Ross, D.; Inayat-Hussain, S. H. Goniothalamin induces coronary artery smooth muscle cells apoptosis: The p53-dependent caspase-2 activation pathway Toxicol. Sci. 2010, 116, 533-548
18. Lan, Y. H.; Chang, F. R.; Liaw, C. C.; Wu, C. C.; Chiang, M. Y.; Wu, Y. C. Digoniodiol, deoxygoniopypyrone A, and goniofupyrone A: Three new styryllactones from Goniothalamus amuyon Planta Med. 2005, 71, 153-159
19. Lan, Y. H.; Chang, F. R.; Yu, J. H.; Yang, Y. L.; Chang, Y. L.; Lee, S. J.; Wu, Y. C. Cytotoxic styrylpyrones from Goniothalamus amuyon J. Nat. Prod. 2003, 66, 487-490
20. Chiu, C. C.; Chang, H. W.; Chuang, D. W.; Chang, F. R.; Chang, Y. C.; Cheng, Y. S.; Tsai, M. T.; Chen, W. Y.; Lee, S. S.; Wang, C. K.; Chen, J. Y.; Wang, H. M.; Chen, C. C.; Liu, Y. C.; Wu, Y. C. Fern plant-derived protoapigenone leads to DNA damage, apoptosis, and G2/M arrest in lung cancer cell line H1299 DNA Cell Biol. 2009, 28, 501-506
21. Yen, C. Y.; Chiu, C. C.; Chang, F. R.; Chen, J. Y.; Hwang, C. C.; Hseu, Y. C.; Yang, H. L.; Lee, A. Y.; Tsai, M. T.; Guo, Z. L.; Cheng, Y. S.; Liu, Y. C.; Lan, Y. H.; Chang, Y. C.; Ko, Y. C.; Chang, H. W.; Wu, Y. C. 4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest BMC Cancer 2010, 10, 46
22. Collins, A. R. The comet assay for DNA damage and repair: Principles, applications, and limitations Mol. Biotechnol. 2004, 26, 249-261 (Pubitemid 41490465)
23. Chiu, C. C.; Li, C. H.; Fuh, T. S.; Chen, W. L.; Huang, C. S.; Chen, L. J.; Ung, W. H.; Fang, K. The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine kinase cDNA Cancer Detect. Prev. 2005, 29, 286-293 (Pubitemid 40779806)
24. Geback, T.; Schulz, M. M.; Koumoutsakos, P.; Detmar, M. TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays BioTechniques 2009, 46, 265-274
25. Tian, Z.; Chen, S.; Zhang, Y.; Huang, M.; Shi, L.; Huang, F.; Fong, C.; Yang, M.; Xiao, P. The cytotoxicity of naturally occurring styryl lactones Phytomedicine 2006, 13, 181-186 (Pubitemid 43120318)
26. Wattanapiromsakul, C.; Wangsintaweekul, B.; Sangprapan, P.; Itharat, A.; Keawpradub, N. Goniothalamin, a cytotoxic compound, isolated from Goniothalamus macrophyllus (Blume) Hook. f. & Thomson var. macrophyllus Songklanakarin J. Sci. Technol. 2005, 27, 479-487
27. de Fatima, A.; Zambuzzi, W. F.; Modolo, L. V.; Tarsitano, C. A.; Gadelha, F. R.; Hyslop, S.; de Carvalho, J. E.; Salgado, I.; Ferreira, C. V.; Pilli, R. A. Cytotoxicity of goniothalamin enantiomers in renal cancer cells: Involvement of nitric oxide, apoptosis and autophagy Chem.-Biol. Interact. 2008, 176, 143-150
28. Rajab, N. F.; Hamid, Z. A.; Hassan, H.; Ali, A. M.; Din, L. B.; Inayat-Hussain, S. H. Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines Environ. Mutagen. Res. 2005, 27, 161-164
29. McKelvey-Martin, V. J.; Ho, E. T.; McKeown, S. R.; Johnston, S. R.; McCarthy, P. J.; Rajab, N. F.; Downes, C. S. Emerging applications of the single cell gel electrophoresis (comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells Mutagenesis 1998, 13, 1-8 (Pubitemid 28052497)
30. Chen, W. Y.; Wu, C. C.; Lan, Y. H.; Chang, F. R.; Teng, C. M.; Wu, Y. C. Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells Eur. J. Pharmacol. 2005, 522, 20-29
31. Liu, M. J.; Yue, P. Y.; Wang, Z.; Wong, R. N. Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria Cancer Lett. 2005, 224, 229-241 (Pubitemid 40725844)
32. Pushkarev, V. M.; Starenki, D. V.; Saenko, V. A.; Yamashita, S.; Kovzun, O. I.; Popadiuk, I. D.; Pushkarev, V. V.; Tronko, M. D. Effects of low and high concentrations of antitumour drug taxol in anaplastic thyroid cancer cells Exp. Oncol. 2009, 31, 16-21
33. Haas-Kogan, D. A.; Kogan, S. C.; Levi, D.; Dazin, P.; TAng, A.; Fung, Y. K.; Israel, M. A. Inhibition of apoptosis by the retinoblastoma gene product EMBO J. 1995, 14, 461-472
34. Ryschich, E.; Khamidjanov, A.; Kerkadze, V.; Buchler, M. W.; Zoller, M.; Schmidt, J. Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer Pancreas 2009, 38, 804-810
35. Ding, H.; Han, C.; Guo, D.; Chin, Y. W.; Ding, Y.; Kinghorn, A. D.; DAmbrosio, S. M. Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism Nutr. Cancer 2009, 61, 348-356
36. 2 exposure Lab. Invest. 1997, 77, 533-539 (Pubitemid 27508624)