4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Yen, Ching Yu ^a,b   Chiu, Chien Chih ^c   Chang, Fang Rong ^c   Chen, Jeff Y ^c   Hwang, Chi Ching ^c   Hseu, You Cheng ^d   Yang, Hsin Ling ^d   Lee, Alan Yueh Luen ^c   Tsai, Ming Tz ^c   Guo, Zong Lun ^c   Cheng, Yu Shan ^c   Liu, Yin Chang ^e   Lan, Yu Hsuan ^d   Chang, Yu Ching ^f   Ko, Ying Chin ^c,g   Chang, Hsueh Wei ^c   Wu, Yang Chang ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^f AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^g NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

4BETA HYDROXYWITHANOLIDE; NATURAL PRODUCT; UNCLASSIFIED DRUG; 4 HYDROXYWITHANOLIDE E; 4-HYDROXYWITHANOLIDE E; ANTINEOPLASTIC AGENT; PLANT EXTRACT; WITHANOLIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; LUNG CARCINOMA; PHYSALIS; PHYSALIS PERUVIANA; CELL DIVISION; CELL NUCLEUS; COMET ASSAY; DOSE RESPONSE; DRUG SCREENING; LUNG TUMOR; METABOLISM; METHODOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CELL NUCLEUS; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; PHYSALIS; PLANT EXTRACTS; WITHANOLIDES;

EID: 77649104750     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-46     Document Type: Article

References (36)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin 2008, 58(2):71-96. 10.3322/CA.2007.0010, 18287387.
2. Bayman NA, Sheikh H, Kularatne B, Lorigan P, Blackhall F, Thatcher N, Faivre-Finn C. Radiotherapy for small-cell lung cancer-Where are we heading?. Lung Cancer 2009, 63(3):307-314. 10.1016/j.lungcan.2008.06.013, 18676057.
3. Saloustros E, Georgoulias V. Docetaxel in the treatment of advanced non-small-cell lung cancer. Expert Rev Anticancer Ther 2008, 8(8):1207-1222. 10.1586/14737140.8.8.1207, 18699760.
4. Yamamoto H, Sekine I, Yamada K, Nokihara H, Yamamoto N, Kunitoh H, Ohe Y, Tamura T. Gender differences in treatment outcomes among patients with non-small cell lung cancer given a combination of carboplatin and paclitaxel. Oncology 2008, 75(3-4):169-174. 10.1159/000159268, 18827494.
5. Vainio H, Weiderpass E. Fruit and vegetables in cancer prevention. Nutr Cancer 2006, 54(1):111-142. 10.1207/s15327914nc5401_13, 16800779.
6. Divisi D, Di Tommaso S, Salvemini S, Garramone M, Crisci R. Diet and cancer. Acta Biomed 2006, 77(2):118-123.
7. Chiu CC, Chang HW, Chuang DW, Chang FR, Chang YC, Cheng YS, Tsai MT, Chen WY, Lee SS, Wang CK, et al. Fern plant-derived protoapigenone leads to DNA damage, apoptosis, and G(2)/m arrest in lung cancer cell line H1299. DNA Cell Biol 2009, 28(10):501-506. 10.1089/dna.2009.0852, 19630532.
8. Tan XL, Spivack SD. Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review. Lung Cancer 2009, 65(2):129-137. 10.1016/j.lungcan.2009.01.002, 19185948.
9. Thomsen A, Kolesar JM. Chemoprevention of breast cancer. Am J Health Syst Pharm 2008, 65(23):2221-2228. 10.2146/ajhp070663, 19020189.
10. Pan MH, Ho CT. Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev 2008, 37(11):2558-2574. 10.1039/b801558a, 18949126.
11. Forte A, De Sanctis R, Leonetti G, Manfredelli S, Urbano V, Bezzi M. Dietary chemoprevention of colorectal cancer. Ann Ital Chir 2008, 79(4):261-267.
12. Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003, 78(3 Suppl):559S-569S.
13. Romieu I, Trenga C. Diet and obstructive lung diseases. Epidemiol Rev 2001, 23(2):268-287.
14. Goldbohm RA, Voorrips LE. Epidemiology of nutrition and lung cancer. Nestle Nutr Workshop Ser Clin Perform Programme 2000, 4:23-35. full_text, 11490576.
15. Xiao H, Yang CS, Li S, Jin H, Ho CT, Patel T. Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel Inhibit growth of human lung cancer cells by apoptosis. Mol Nutr Food Res 2009, 53(3):398-406. 10.1002/mnfr.200800057, 19065586.
16. Wu SJ, Tsai JY, Chang SP, Lin DL, Wang SS, Huang SN, Ng LT. Supercritical carbon dioxide extract exhibits enhanced antioxidant and anti-inflammatory activities of Physalis peruviana. J Ethnopharmacol 2006, 108(3):407-413. 10.1016/j.jep.2006.05.027, 16820275.
17. Franco LA, Matiz GE, Calle J, Pinzon R, Ospina LF. Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calyces. Biomedica 2007, 27(1):110-115.
18. Pardo JM, Fontanilla MR, Ospina LF, Espinosa L. Determining the pharmacological activity of Physalis peruviana fruit juice on rabbit eyes and fibroblast primary cultures. Invest Ophthalmol Vis Sci 2008, 49(7):3074-3079. 10.1167/iovs.07-0633, 18579763.
19. Wu SJ, Ng LT, Chen CH, Lin DL, Wang SS, Lin CC. Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells. Life Sci 2004, 74(16):2061-2073. 10.1016/j.lfs.2003.09.058, 14967200.
20. Hsieh PW, Huang ZY, Chen JH, Chang FR, Wu CC, Yang YL, Chiang MY, Yen MH, Chen SL, Yen HF, et al. Cytotoxic withanolides from Tubocapsicum anomalum. J Nat Prod 2007, 70(5):747-753. 10.1021/np0605541, 17417907.
21. Ahmad S, Malik A, Afza N, Yasmin R. A new withanolide glycoside from physalis peruviana. J Nat Prod 1999, 62(3):493-494. 10.1021/np980228o, 10096867.
22. Sakurai K, Ishii H, Kobayashi S, Iwao T. Isolation of 4 beta-hydroxywithanolide E, a new withanolide from Physalis peruviana L. Chem Pharm Bull (Tokyo) 1976, 24(6):1403-1405.
23. Dinan LN, Sarker SD, Šik V. 28-Hydroxywithanolide E from Physalis peruviana. Phytochemistry 1997, 44:509-512.
24. Chiang SL, Jiang SS, Wang YJ, Chiang HC, Chen PH, Tu HP, Ho KY, Tsai YS, Chang IS, Ko YC. Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci 2007, 100(1):66-74. 10.1093/toxsci/kfm201, 17682004.
25. Chang YC, Liao CB, Hsieh PY, Liou ML, Liu YC. Expression of tumor suppressor p53 facilitates DNA repair but not UV-induced G2/M arrest or apoptosis in Chinese hamster ovary CHO-K1 cells. J Cell Biochem 2008, 103(2):528-537. 10.1002/jcb.21428, 17549699.
26. Chang YC, Jan KY, Cheng CA, Liao CB, Liu YC. Direct involvement of the tumor suppressor p53 in nucleotide excision repair. DNA Repair (Amst) 2008, 7(5):751-761. 10.1016/j.dnarep.2008.01.019, 18343205.
27. Wong VWC, Szeto YT, Collins AR, Benzie IFF. The comet assay: a biomonitoring tool for nutraceutical research. Curr Top Nutraceutical Res 2005, 3:1-14.
28. Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004, 26(3):249-261. 10.1385/MB:26:3:249, 15004294.
29. Chiu CC, Li CH, Fuh TS, Chen WL, Huang CS, Chen LJ, Ung WH, Fang K. The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine kinase cDNA. Cancer Detect Prev 2005, 29(3):286-293. 10.1016/j.cdp.2005.02.001, 15916863.
30. Chien CM, Yang SH, Yang CC, Chang LS, Lin SR. Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells. Cell Biochem Funct 2008, 26(1):111-118. 10.1002/cbf.1420, 17514639.
31. Chiu CC, Li CH, Ung MW, Fuh TS, Chen WL, Fang K. Etoposide (VP-16) elicits apoptosis following prolonged G2-M cell arrest in p53-mutated human non-small cell lung cancer cells. Cancer Lett 2005, 223(2):249-258. 10.1016/j.canlet.2004.10.049, 15896459.
32. Reed JC. Mechanisms of apoptosis avoidance in cancer. Curr Opin Oncol 1999, 11(1):68-75. 10.1097/00001622-199901000-00014, 9914881.
33. Hsu S, Singh B, Schuster G. Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention. Oral Oncol 2004, 40(5):461-473. 10.1016/j.oraloncology.2003.09.012, 15006617.
34. Wang AS, Ramanathan B, Chien YH, Goparaju CM, Jan KY. Comet assay with nuclear extract incubation. Anal Biochem 2005, 337(1):70-75. 10.1016/j.ab.2004.10.024, 15649377.
35. Li PY, Chang YC, Tzang BS, Chen CC, Liu YC. Antibiotic amoxicillin induces DNA lesions in mammalian cells possibly via the reactive oxygen species. Mutat Res 2007, 629(2):133-139.
36. Collins AR, Dusinska M, Horvathova E, Munro E, Savio M, Stetina R. Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay. Mutagenesis 2001, 16(4):297-301. 10.1093/mutage/16.4.297, 11420396.