Evaluating antibody monomer separation from associated aggregates using mixed-mode chromatography

Journal of Chromatography A

Volumn 1294, Issue , 2013, Pages 70-75

  Gao, Dong ^a   Wang, Li Li ^a   Lin, Dong Qiang ^b   Yao, Shan Jing ^b  

^a NORTHWEST UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Aggregate removal; Antibody; Capto adhere; Mixed mode chromatography

Indexed keywords

CAPTO ADHERE; FUNCTIONAL LIGANDS; HYDROPHOBIC INTERACTIONS; MANUFACTURING PROCESS; MIXED-MODE CHROMATOGRAPHY; REMOVAL EFFICIENCIES; SEPARATION METHODS; SEPARATION PERFORMANCE;

ANTIBODIES; BIOACTIVITY; CHROMATOGRAPHY; LOADING; MOLECULAR INTERACTIONS; MOLECULAR STRUCTURE; RESINS; SEPARATION;

AGGREGATES;

BENZYLAMINE; BUTYLAMINE; CAPTO ADHERE; MONOCLONAL ANTIBODY; MONOMER; PHENYL SEPHAROSE 6 FF; PROTEIN A; Q SEPHAROSE FF; RESIN; SEPHAROSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHROMATOGRAPHY; COOPERATION; HYDROPHOBICITY; MIXED MODE CHROMATOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; STATIC ELECTRICITY;

ADSORPTION; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; SEPHAROSE;

EID: 84877926237     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.04.018     Document Type: Article

References (42)

1. Reichert J.M. mAbs 2011, 3:76.
2. Cromwell M.E.M., Hilario E., Jacobson F. AAPS J. 2006, 8:E572.
3. Vázquez-Rey M., Lang D.A. Biotechnol. Bioeng. 2011, 108:1494.
4. Franco R., Daniela G., Fabrizio M., Ilaria G., Detlev H. Cytotechnology 1999, 29:11.
5. Rosenberg A.S. AAPS J. 2006, 8:E501.
6. van Beers M.M., Sauerborn M., Gilli F., Brinks V., Schellekens H., Jiskoot W. Pharm. Res. 2010, 27:1812.
7. Suda E.J., Thomas K.E., Pabst T.M., Mensah P., Ramasubramanyan N., Gustafson M.E. J. Chromatogr. A 2009, 1216:5256.
8. Yigzaw Y., Hinckley P., Hewig A., Vedantham G. Curr. Pharm. Biotechnol. 2009, 10:421.
9. Lu Y.F., Williamson B., Gillespie R. Curr. Pharm. Biotechnol. 2009, 10:427.
10. McCue J.T., Engel P., Thömmes J. J. Chromatogr. A 2009, 1216:902.
11. Gagnon P. Nat. Biotechnol. 2009, 25:287.
12. Gagnon P. J. Immunol. Methods 2008, 336:222.
13. McCue J.T., Cecchini D., Hawkins K., Dolinski E. J. Chromatogr. A 2007, 1165:78.
14. Burton S.C., Harding D.R. J. Biochem. Biophys. Methods 2001, 49:275.
15. Zhao G.F., Dong X.Y., Sun Y. J. Biotechnol. 2009, 144:3.
16. Yang Y., Geng X.D. J. Chromatogr. A 2011, 1218:8813.
17. Nfor B.K., Noverraz M., Chilamkurthi S. J. Chromatogr. A 2010, 1217:6829.
18. Hofer S., Ronacher A., Horak J., Graalfs H., Lindner W. J. Chromatogr. A 2011, 1218:8925.
19. Gao D., Lin D.Q., Yao S.J. Chem. Eng. Sci. 2006, 61:7260.
20. Hou Y., Cramer S.M. J. Chromatogr. A 2011, 1218:7813.
21. Zhao G.F., Peng G.Y., Li F.Q., Shi Q.H., Sun Y. J. Chromatogr. A 2008, 1211:90.
22. Zhang L., Bai S., Sun Y. J. Mol. Graph. Model. 2010, 28:863.
23. Lin D.Q., Tong H.F., Wang H.Y. J. Chromatogr. A 2012, 1260:143.
24. Kaleas K.A., Schmelzer C.H., Pizarro S.A. J. Chromatogr. A 2010, 1217:235.
25. Voitl A., Müller-Späth T., Morbidelli M. J. Chromatogr. A 2010, 1217:5753.
26. Toueille M., Uzel A., Depoisier J.-F., Gantier R. J. Chromatogr. B 2011, 879:836.
27. F. Oehme, J. Peters, BioPharm Int. Suppl. March 2, 2010, . http://www.biopharminternational.com/biopharm/Downstream+Processing/Mixed-Mode-Chromatography-in-Downstream-Process-De/ArticleStandard/Article/detail/659499.
28. Gagnon P. Curr. Pharm. Biotechnol. 2009, 10:434.
29. GE Healthcare Inc., Application Note, 2007, 28-9078-93 AA.
30. Chen J., Tetrault J., Zhang Y., Wasserman A., Conley G., DiLeo M., Haimes E., Nixon A.E., Ley A. J. Chromatogr. A 2010, 1217:216.
31. Gao D., Yao S.J., Lin D.Q. J. Appl. Polym. Sci. 2008, 107:674.
32. Wan Y.H., Vasan S., Ghosh R. Biotechnol. Bioeng. 2005, 90:422.
33. Kilar F., Zavodzky P. Eur. J. Biochem. 1987, 162:57.
34. Wang L., Ghosh R. J. Membr. Sci. 2008, 318:311.
35. Nagaoka S., Kanno M., Kawakami H., Kubota S. J. Artif. Organs 2001, 4:107.
36. Wang L., Hale G., Ghosh R. Anal. Chem. 2006, 78:6863.
37. Buijs J., Norde W., Lichtenbelt J.W.T. Langmuir 1996, 12:1605.
38. Zhou J., Tsao H.K., Sheng Y.J. J. Chem. Phys. 2004, 121:1050.
39. Zhou J., Chen S.F., Jiang S.Y. Langmuir 2003, 19:3472.
40. Jin M., Szapiel N., Zhang J., Hickey J., Ghose S. Biotechnol. Bioeng. 2010, 105:306.
41. Yoo S.M., Ghosh R. J. Membr. Sci. 2012, 390-391:263.
42. McCue J.T., Engel P., Ng A., Macniven R., Thömmes J. Bioprocess Biosyst. Eng. 2008, 31:261.