Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates

Journal of Chromatography A

Volumn 1216, Issue 27, 2009, Pages 5256-5264

  Suda, Eric J ^a   Thomas, Kristin E ^a   Pabst, Timothy M ^a   Mensah, Paul ^a   Ramasubramanyan, Natraj ^a   Gustafson, Mark E ^a   Hunter, Alan K ^a  

^a PFIZER INC   (United States)

Author keywords

Aggregates; BSA; Ion exchange; Monoclonal antibody; Monomer; Protein

Indexed keywords

AGAROSE; BOVINE SERUM ALBUMINS; BSA; DYNAMIC BINDING CAPACITY; FLOWTHROUGH; LINEAR GRADIENT ELUTION; MASS TRANSFER RATE; MODEL PROTEINS; PROCESS DEVELOPMENT; PROTEIN AGGREGATES; PROTEIN PURIFICATION; RECOMBINANT PROTEIN;

AGGREGATES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; DEXTRAN; GEL PERMEATION CHROMATOGRAPHY; GLUCOSE; GRAFTING (CHEMICAL); ION EXCHANGERS; IONS; MONOCLONAL ANTIBODIES; MONOMERS; PROTEINS; SEPARATION; SURFACE PLASMON RESONANCE;

ION EXCHANGE;

AGAROSE; BOVINE SERUM ALBUMIN; DEXTRAN; DRUG; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SEPHAROSE;

ARTICLE; BINDING AFFINITY; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG MANUFACTURE; ELUTION; ION EXCHANGE; ION EXCHANGER; ION TRANSPORT; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN PURIFICATION;

ADSORPTION; ANIMALS; CATTLE; CHROMATOGRAPHY, ION EXCHANGE; DEXTRANS; ION EXCHANGE RESINS; PROTEIN BINDING; SEPHAROSE; SERUM ALBUMIN, BOVINE;

BOVINAE;

EID: 66249103015     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.05.021     Document Type: Article

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