Static and dynamic binding capacities of human immunoglobulin G on polymethacrylate based mixed-modal, thiophilic and hydrophobic cation exchangers

Journal of Chromatography A

Volumn 1218, Issue 49, 2011, Pages 8925-8936

  Hofer, Stefan ^a   Ronacher, Alexander ^a   Horak, Jeannie ^a   Graalfs, Heiner ^b   Lindner, Wolfgang ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MERCK KGAA   (Germany)

Author keywords

Antibody purification; Cation exchange; Cell culture supernatant; Hydrophobic interaction chromatography; Mixed modal ligands; Thiophilic adsorption

Indexed keywords

ANTIBODY PURIFICATION; CATION EXCHANGES; CELL CULTURE SUPERNATANT; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; THIOPHILIC;

ADSORPTION; AMIDES; ANIMAL CELL CULTURE; AROMATIC COMPOUNDS; CARBOXYLIC ACIDS; FUNCTIONAL GROUPS; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; ION EXCHANGE; LIGANDS; LIQUID CHROMATOGRAPHY; MATERIALS; POSITIVE IONS; SODIUM CHLORIDE;

ANTIBODIES;

IMMUNOGLOBULIN G; POLOXAMER; POLYMETHACRYLIC ACID; SODIUM CHLORIDE;

ADSORPTION KINETICS; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; CROSS LINKING; HUMAN; HYDROPHILICITY; IMMOBILIZATION; ION EXCHANGE; MOLECULAR DYNAMICS; OXIDATION; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SUPERNATANT; SYNTHESIS;

ACETYLCYSTEINE; ADSORPTION; ANIMALS; ANTIBODIES, MONOCLONAL; CATIONS; CELLS, CULTURED; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HOMOCYSTEINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; ION EXCHANGE RESINS; LIGANDS; POLOXAMER; POLYMETHACRYLIC ACIDS; PROTEIN BINDING; SILVER STAINING; SODIUM CHLORIDE;

EID: 82955212873     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.06.012     Document Type: Article

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