Simultaneous removal of leached protein-A and aggregates from monoclonal antibody using hydrophobic interaction membrane chromatography

Journal of Membrane Science

Volumn 390-391, Issue , 2012, Pages 263-269

  Yoo, Seung Mi ^a   Ghosh, Raja ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Aggregates; Hydrophobic interaction; Membrane chromatography; Monoclonal antibody; Polishing; Protein A

Indexed keywords

ACIDIC CONDITIONS; FLOWTHROUGH; HYDROPHOBIC INTERACTIONS; MEMBRANE CHROMATOGRAPHY; MEMBRANE STACKS; MONOCLONAL ANTIBODIES (MABS); MONOMERIC FORMS; OPERATING CONDITION; POLISHING TECHNIQUES; PROTEIN-A; REVERSIBLE ADSORPTION; SALT CONCENTRATION; SEPARATION METHODS; SIMULTANEOUS REMOVAL; THERAPEUTIC APPLICATION;

ADSORPTION; AFFINITY CHROMATOGRAPHY; AGGREGATES; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; LEACHING; MEMBRANES; MONOCLONAL ANTIBODIES; POLISHING;

PROTEINS;

MONOCLONAL ANTIBODY; PROTEIN A; SODIUM CHLORIDE;

ADSORPTION KINETICS; ARTICLE; CONCENTRATION (PARAMETERS); EFFLUENT; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBICITY; LEACHING; MEMBRANE; PRIORITY JOURNAL; PROTEIN AGGREGATION;

EID: 84855273778     PISSN: 03767388     EISSN: 18733123     Source Type: Journal    
DOI: 10.1016/j.memsci.2011.11.049     Document Type: Article

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