Application of mixed mode resins for the purification of antibodies

Journal of Chromatography A

Volumn 1217, Issue 37, 2010, Pages 5753-5760

  Voitl, Agnes ^a   Müller Späth, Thomas ^a,b   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b CHROMACON AG   (Switzerland)

Author keywords

Downstream processing; Mixed mode chromatography; Monoclonal antibody; Polishing; Protein; Purification

Indexed keywords

ADSORPTION STRENGTH; ANION EXCHANGE; CULTURE SUPERNATANT; DOWNSTREAM-PROCESSING; HENRY COEFFICIENTS; HYDROPHOBIC INTERACTIONS; MIXED MODE; MIXED-MODE CHROMATOGRAPHY; POLISHING STEPS; PRODUCT PURITY; SALT CONCENTRATION; STATIONARY PHASE; WORKING RANGE;

ADSORPTION; ALLERGIES; CELL CULTURE; FUNCTIONAL POLYMERS; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; POLISHING; PROTEINS; RESINS; SURFACE PLASMON RESONANCE;

PURIFICATION;

BEVACIZUMAB; CETUXIMAB; RESIN; SODIUM CHLORIDE;

ADSORPTION; ANION EXCHANGE; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG PURIFICATION; HYDROPHOBICITY; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; STEADY STATE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, CONDITIONED; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; POROSITY; PROTEINS; SODIUM CHLORIDE;

EID: 77955927815     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.06.047     Document Type: Article

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