Identification of LRP16 as a negative regulator of insulin action and adipogenesis in 3T3-L1 adipocytes

Hormone and Metabolic Research

Volumn 45, Issue 5, 2013, Pages 349-358

  Zang, L ^a   Xue, B ^a   Lu, Z ^a   Li, X ^a   Yang, G ^a   Guo, Q ^a   Ba, J ^a   Zou, X ^a   Dou, J ^a   Lu, J ^a   Pan, C ^a   Mu, Y ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

insulin receptor substrate 1 (IRS 1); leukemia related protein 16 (LRP16); mammalian target of rapamycin (mTOR); peroxisome proliferator activated receptor gamma (PPAR ); tumor necrosis factor alpha (TNF )

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LEUKEMIA RELATED PROTEIN 16; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OBESITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; DOWN-REGULATION; GENE SILENCING; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; NEOPLASM PROTEINS; PHOSPHORYLATION; PPAR GAMMA; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MAMMALIA;

EID: 84877874455     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1331215     Document Type: Article

References (46)

1. Jeffery R. W., Sherwood N. E. Is the obesity epidemic exaggerated? No MMJ: 2008; 336 245
2. Stumvoll M., Goldstein B. J., van Haeften T. W. Type 2 diabetes: pathogenesis and treatment. Lancet: 2008; 371 2153 2156 (Pubitemid 351885026)
3. Moller D. E., Flier J. S. Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med: 1991; 325 938 948
4. Nishiumi S., Yoshida M., Azuma T., Yoshida K., Ashida H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs an insulin signaling pathway through the induction of tumor necrosis factor-alpha in adipocytes. Toxicol Sci: 2010; 115 482 491
5. Cheatham B., Vlahos C. J., Cheatham L., Wang L., Blenis J., Kahn C. R. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol: 1994; 14 4902 4911 (Pubitemid 24196839)
6. Shepherd P. R., Navé B. T., Siddle K. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem J: 1995; 305 25 28
7. Lazar D. F., Wiese R. J., Brady M. J., Mastick C. C., Waters S. B., Yamauchi K., Pessin J. E., Cuatrecasas P., Saltiel A. R. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem: 1995; 270 20801 20807
8. Sutherland C., Waltner-Law M., Gnudi L., Kahn B. B., Granner D. K. Activation of the Ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin. J Biol Chem: 1998; 273 3198 3204 (Pubitemid 28109728)
9. Ishiki M., Klip A. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology: 2005; 146 5071 5078 (Pubitemid 41653019)
10. Goossens G. H. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav: 2008; 94 206 218 (Pubitemid 351615418)
11. Kim J. H., Bachmann R. A., Chen J. Interleukin-6 and insulin resistance. Vitam Horm: 2009; 80 613 633
12. Hotamisligil G. S., Shargill N. S., Spiegelman B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science: 1993; 259 87 91 (Pubitemid 23036092)
13. Jager J., Grémeaux T., Cormont M., Le Marchand-Brustel Y., Tanti J. F. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology: 2007; 148 241 251 (Pubitemid 46021456)
14. Han W. D., Yu L., Lou F. D., Wang Q. S., Zhao Y., Shi Z. J., Jin H. J. The Application of RACE Technique to Clone the Full-Length cDNA of A Novel Leukemia Associated Gene LRP16. Zhongguo Shi Yan Xue Ye Xue Za Zhi: 2001; 9 18 21
15. Wu Z., Li Y., Li X., Ti D., Zhao Y., Si Y., Mei Q., Zhao P., Fu X., Han W. LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation. PLoS One: 2011; 6 e18157
16. Imagama S., Abe A., Suzuki M., Hayakawa F., Katsumi A., Emi N., Kiyoi H., Naoe T. LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Eur J Haematol: 2007; 79 25 31 (Pubitemid 47000610)
17. Yang B., Lu X. C., Chi X. H., Han W. D., Yu L., Lou F. D. Promotive effect of LRP16 gene on proliferation of K562 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi: 2009; 17 1154 1158
18. Han W. D., Si Y. L., Zhao Y. L., Li Q., Wu Z. Q., Hao H. J., Song H. J. GC-rich promoter elements maximally confers estrogen-induced transactivation of LRP16 gene through ERalpha/Sp1 interaction in MCF-7 cells. J Steroid Biochem Mol Biol: 2008; 109 47 56
19. Yang J., Zhao Y. L., Wu Z. Q., Si Y. L., Meng Y. G., Fu X. B., Mu Y. M., Han W. D. The single-macro domain protein LRP16 is an essential cofactor of androgen receptor. Endocr Relat Cancer: 2009; 16 139 153
20. Geer E. B., Shen W. Gender differences in insulin resistance, body composition, and energy balance. Gend Med: 2009; 6 01 60 75
21. Zang L., Mu Y. M., Lü Z. H., Xue B., Ma X. L., Yang G. Q., Ba J. M., Dou J. T., Lu J. M. LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of peroxisome proliferator actived receptor γ Zhonghua Yi Xue Za Zhi: 2011; 91 1408 1412
22. Han W. D., Zhao Y. L., Meng Y. G., Zang L., Wu Z. Q., Li Q., Si Y. L., Huang K., Ba J. M., Morinaga H., Nomura M., Mu Y. M. Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity. Endocr Relat Cancer: 2007; 14 741 753 (Pubitemid 350074063)
23. Han W. D., Li Q., Zhao Y. L., Mu Y. M., Li X. Inhibition of Cell Proliferation by Small Interference RNA Against LRP16 Gene in Human Breast Cancer MCF-7 Cells. Chin J Biochem Mol Biol: 2005; 23 113 119 (Pubitemid 40578185)
24. Muraki K., Okuya S., Tanizawa Y. Estrogen receptor alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes. Endocr J: 2006; 53 841 851 (Pubitemid 46045131)
25. Luo J., Field S. J., Lee J. Y., Engelman J. A., Cantley L. C. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol: 2005; 170 455 464 (Pubitemid 41126944)
26. Koshy S., Alizadeh P., Timchenko L. T., Beeton C. Quantitative measurement of GLUT4 translocation to the plasma membrane by flow cytometry. J Vis Exp. 2010; e2429
27. Kim J. E., Chen J. Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes: 2004; 53 2748 2756 (Pubitemid 39425899)
28. Bloch-Damti A., Potashnik R., Gual P., Le Marchand-Brustel Y., Tanti J. F., Rudich A., Bashan N. Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia: 2006; 49 2463 2473 (Pubitemid 44359109)
29. Myers M. G. Jr. Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci USA: 1992; 89 10350 10354
30. Ozes O. N., Mayo L. D., Gustin J. A., Pfeffer S. R., Pfeffer L. M., Donner D. B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature: 1999; 401 82 85
31. Ozes O. N., Akca H., Mayo L. D., Gustin J. A., Maehama T., Dixon J. E., Donner D. B. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA: 2001; 98 4640 4645 (Pubitemid 32295029)
32. Kanai F., Ito K., Todaka M., Hayashi H., Kamohara S., Ishii K., Okada T., Hazeki O., Ui M., Ebina Y. Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem Biophys Res Commun: 1993; 195 762 768 (Pubitemid 23280482)
33. Khamzina L., Veilleux A., Bergeron S., Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology: 2005; 146 1473 1481 (Pubitemid 40289337)
34. Trembley F., Gagnon A., Veilleux A., Sorisky A., Marette A. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology: 2005; 146 1328 1337 (Pubitemid 40289320)
35. Scazzocchio B., Varì R., D'Archivio M., Santangelo C., Filesi C., Giovannini C., Masella R. Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases. J Lipid Res: 2009; 50 832 845
36. Bulun S. E., Yang S., Fang Z., Gurates B., Tamura M., Zhou J., Sebastian S. Role of aromatase in endometrial disease. J Steroid Biochem Mol Biol: 2001; 79 19 25 (Pubitemid 34158774)
37. Van Pelt R. E., Gozansky W. S., Hickner R. C., Schwartz R. S., Kohrt W. M. Acute modulation of adipose tissue lipolysis by intravenous estrogens. Obesity (Silver Spring): 2006; 14 2163 2172 (Pubitemid 46121971)
38. Stephens J. M., Lee J., Pilch P. F. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem: 1997; 272 971 976 (Pubitemid 27034588)
39. Chen X. L., Xia Z. F., Ben D. F., Duo W. mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn. Burns: 2011; 37 86 93
40. Schoonjans K., Staels B., Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res: 1996; 37 907 925 (Pubitemid 26182326)
41. Spiegelman B. M. PPAR-γ: adipogenic regulator and thiazolinedione receptor. Diabetes: 1998; 47 507 514 (Pubitemid 28160438)
42. Zhang B., Berger J., Hu E., Szalkowski D., White-Carrington S., Spiegelman B. M., Moller D. E. Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol: 1996; 10 1457 1466 (Pubitemid 26423234)
43. Cho H. J., Park J., Lee H. W., Lee Y. S., Kim J. B. Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem Biophys Res Commun: 2004; 321 942 948 (Pubitemid 39055987)
44. El-Chaar D., Gagnon A., Sorisky A. Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1. Int J Obes Relat Metab Disord: 2004; 28 191 198 (Pubitemid 38223499)
45. Yu J., Henske E. P. Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain. Cancer Res: 2006; 66 9461 9466 (Pubitemid 44623643)
46. Sabio G., Davis R. J. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci: 2010; 35 490 496