The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

Endocrine-Related Cancer

Volumn 16, Issue 1, 2009, Pages 139-153

  Yang, J ^a   Zhao, Y L ^a   Wu, Z Q ^a   Si, Y L ^a   Meng, Y G ^a   Fu, X B ^a   Mu, Y M ^a   Han, W D ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CELL PROTEIN; PROTEIN ART 27; PROTEIN LRP16; STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; HISTONE ACETYLTRANSFERASE; LIGAND; LRP16 PROTEIN, HUMAN; LUCIFERASE; SMALL INTERFERING RNA; TUMOR PROTEIN; UXT PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; TRANSACTIVATION; BREAST TUMOR; CELL DIVISION; CELL FREE SYSTEM; CHEMISTRY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; PROSTATE TUMOR; PROTEIN TERTIARY STRUCTURE; TRANSCRIPTION INITIATION; TUMOR CELL LINE; UPREGULATION;

BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CELL-FREE SYSTEM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE ACETYLTRANSFERASES; HUMANS; LIGANDS; LUCIFERASES; MALE; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 65549148622     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-08-0150     Document Type: Article

References (47)

1. Aguiar RCT, Takeyama K, He C, Kreinbrink K & Shipp MA 2005 B-aggressive lymphoma family protein have unique domains that modulate transcription and exhibit poly (ADP-ribose) polymerase activity. Journal of Biological Chemistry 280 33756-33765.
2. Amé JC, Spenlehauer C & de Murcia G 2004 The PARP superfamily. BioEssays 26 882-893.
3. Angelov D, Molla A, Perche PY, Hans F, Cote J, Khochbin S, Bouvet P & Dimitrov S 2003 The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Molecular Cell 11 1033-1041.
4. Bevan CL, Hoare S, Claessens F, Heery DM & Parker MG 1999 The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC-1. Molecular and Cellular Biology 19 8383-8392.
5. Brinkmann AO, Faber PW, van Rooij HCJ, Kuiper GGJM, Ris C, Klaassen P, van der Korput JAHM, Voorhorst MM, van Laar JH, Mulder E et al. 1989 The human androgen receptor: domain structure, genomic organization and regulation of expression. Journal of Steroid Biochemistry 34 307-310.
6. Chang CY & McDonnell DP 2005 Androgen receptor-cofactor interactions as targets for new drug discovery. Trends in Pharmacological Sciences 26 225-228.
7. Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E & Loosfelt H 2000 JAB1 interacts with both the progesterone receptor and SRC-1. Journal of Biological Chemistry 275 8540-8548.
8. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y & Evans RM 1997 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90 569-580.
9. Corda D & Girolamo MD 2003 Functional aspects of protein mono-ADP-ribosylation. EMBO Journal 22 1953-1958.
10. Culver GM, Consaul SA, Tycowski KT, Filipowicz W & Phizicky EM 1994 tRNA splicing in yeast and wheat germ. A cyclic phosphodiesterase implicated in the metabolism of ADP-ribose 1″, 2″-cyclic phosphate. Journal of Biological Chemistry 269 24928-24934.
11. Dehm SM & Tindall DJ 2006 Molecular regulation of androgen action in prostate cancer. Journal of Cellular Biochemistry 99 333-344.
12. Dehm SM & Tindall DJ 2007 Androgen receptor structural and functional elements: role and regulation in prostate cancer. Molecular Endocrinology 21 2855-2863.
13. Egloff MP, Malet H, Putics Á, Heinonen M, Dutartre H, Frangeul A, Gruez A, Campanacci V, Cambillau C, Ziebuhr J et al. 2006 Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. Journal of Virology 80 8493-8502.
14. Goenka S & Boothby M 2006 Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. PNAS 103 4210-4215.
15. Han WD, Yu L, Lou FD, Wang QS, Zhao Y, Shi ZJ, Jiao HY & Zhou JJ 2001 Cloning and expression characteristics of the full length cDNA for a novel leukemia-associated gene LRP16. Academic Journal of PLA Postgraduate Medical School 17 209-214.
16. Han WD, Lou FD, Yu L, Han XP, Wang QS, Li N & Zhou CX 2002 Bioinformatic analysis and subcellular distribution of LRP16 protein. Academic Journal of PLA Postgraduate Medical School 23 277-279.
17. Han WD, Mu YM, Lu XC, Xu ZM, Li XJ, Yu L, Song HJ, Li M, Lu JM, Zhao YL et al. 2003 Up-regulation of LRP16 mRNA by 17β-estradiol through activation of estrogen receptor α ERα, but not estrogen receptor β ERβ and promotes human breast cancer MCF-7 cell proliferation: a preliminary report. Endocrine-Related Cancer 10 217-224.
18. Han WD, Zhao YL, Meng YG, Zang L, Wu ZQ, Li Q, Si YL, Huang K, Ba JM, Morinaga H et al. 2007 Estrogenically regulated ERα target gene LRP16 interacts with ERα and enhances the receptor's transcriptional activity. Endocrine-Related Cancer 14 741-753.
19. Han WD, Si YL, Zhao YL, Li Q, Wu ZQ, Hao HJ & Song HJ 2008 GC-rich promoter elements maximally confer estrogen-induced transactivation of LRP16 gene through ERα/Sp1 interaction in MCF-7 cells. Journal of Steroid Biochemistry and Molecular Biology 109 47-56.
20. Hassa PO, Haenni SS, Elser M & Hottiger MO 2006 Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiology and Molecular Biology Reviews 70 789-829.
21. He B, Kemppainen JA & Wilson EM 2000 FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. Journal of Biological Chemistry 275 22986-22994.
22. Heemers HV & Tindall DJ 2007 Androgen receptor coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocrine Reviews 28 778-808.
23. Heemers HV, Regan KM, Dehm SM & Tindall DJ 2007 Androgen induction of the androgen coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer. Cancer Research 67 10592-10599.
24. Hong CY, Suh JH, Kim K, Gong EY, Jeon SH, Ko M, Seong RH, Kwon HB & Lee K 2005 Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. Molecular and Cellular Biology 25 4841-4852.
25. Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H & Naoe T 2007 LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). European Journal of Haematology 79 25-31.
26. Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M & Ladurner AG 2005 The macro domain is an ADP-ribose module. EMBO Journal 24 1911-1920.
27. Kraus WL & Lis JT 2003 PARP goes transcription. Cell 113 677-683.
28. Kumaran D, Eswaramoorthy S, Studier FW & Swaminathan S 2005 Structure and mechanism of ADP-ribose-1″-monophosphatase (Appr-100-pase), a ubiquitous cellular processing enzyme. Protein Science 14 719-726.
29. Kustatscher G, Hothorn M, Pugieux C, Scheffzek K & Ladurner AG 2005 Splicing regulation NAD metabolite binding to histone macroH2A. Nature Structural and Molecular Biology 12 624-625.
30. Ladurner AG 2003 Inactivating chromosomes: a macro domain that minimizes transcription. Molecular Cell 12 1-4.
31. Lee HJ & Chang C 2003 Recent advances in androgen receptor action. Cellular and Molecular Life Sciences 60 1613-1622.
32. Liao DX, Han WD, Zhao YL, Pu YD, Mu YM, Luo CH & Li XH 2006 The expression and clinical significance of LRP16 gene in human breast cancer. Ai Zheng 25 866-870.
33. Markus SM, Taneja SS, Logan SK, Li WH, Ha S, Hittelman AB, Rogatsky I & Garabedian MJ 2002 Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Molecular and Cellular Biology 13 670-682.
34. McKenna NJ & O'Malley BW 2002 Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108 465-474.
35. McKenna NJ, Lanz RB & O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews 20 321-344.
36. Meng YG, Han WD, Zhao YL, Huang K, Si YL, Wu ZQ & Mu YM 2007 Induction of LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through down-regulation of E-cadherin. Cell Research 17 869-880.
37. Nelson CC, Hendy SC, Shukin RJ, Cheng H, Bruchovsky N, Koop BF & Rennie PS 1999 Determinants of DNA sequence specificity of the androgen, progesterone, and glucocorticoid receptors: evidence for differential steroid receptor response elements. Molecular Endocrinology 13 2090-2107.
38. Pehrson JR & Fried VA 1992 MacroH2A, a core histone containing a large nonhistone region. Science 257 1398-1400.
39. Powell SM, Christiaens V, Voulgaraki D, Waxman J, Claessens F & Bevan CL 2004 Mechanisms of androgen receptor signaling via steroid receptor coactivator-1 in prostate. Endocrine-Related Cancer 11 117-130.
40. Rosenfeld MG, Lunyak VV & Glass CK 2006 Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes and Development 20 1405-1428.
41. van Royen ME, Cunha SM, Brink MC, Mattern KA, Nigg AL, Dubbink HJ, Verschure PJ, Trapman J & Houtsmuller AB 2007 Compartmentalization of androgen receptor protein-protein interactions in living cells. Journal of Cell Biology 177 63-72.
42. Smith S, Giriat I, Schmitt A & de Lange T 1998 Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282 1484-1487.
43. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ et al. 1997 Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389 194-198.
44. Taneja SS, Ha S, Swenson NK, Torra IP, Rome S, Walden PD, Huang HY, Shapiro E, Garabedian MJ & Logan SK 2004 ART-27, an androgen receptor coactivator regulated in prostate development and cancer. Journal of Biological Chemistry 279 13944-13952.
45. Toumazou C, Li J & Wong J 2008 Cofactor restriction by androgen receptor N-terminal and C-terminal interaction Molecular Endocrinology [in press].
46. White R & Parker MG 1998 Molecular mechanisms of steroid hormone action. Endocrine-Related Cancer 5 1-14.
47. Zhao YL, Han WD, Li Q, Mu YM, Lu XC, Yu L, Song HJ, Lu JM & Pan CY 2005 Mechanism of transcriptional regulation of LRP16 gene expression by 17-β estradiol in MCF-7 human breast cancer cells. Journal of Molecular Endocrinology 34 77-89.