Role of aromatase in endometrial disease

Journal of Steroid Biochemistry and Molecular Biology

Volumn 79, Issue 1-5, 2001, Pages 19-25

  Bulun, Serdar E ^a   Yang, Sijun ^a   Fang, Zongjuan ^a   Gurates, Bilgin ^a   Tamura, Mitsutoshi ^a   Zhou, Jianfeng ^a   Sebastian, Siby ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

17 Hydroxysteroid dehydrogenase type 2; Aromatase; Aromatase inhibitor; Endometriosis; Endometrium; Estrogen; Estrogen biosynthesis; Estrogen metabolism; Osteoporosis; Progesterone; Steroidogenesis

Indexed keywords

AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTRONE; PROSTAGLANDIN E2; TESTOSTERONE 17BETA DEHYDROGENASE;

ADIPOSE TISSUE; BRAIN; CONFERENCE PAPER; ENDOMETRIOSIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; HUMAN; OVARY; POSTMENOPAUSE; PROTEIN EXPRESSION; SKIN;

AROMATASE; AROMATASE INHIBITORS; DINOPROSTONE; ENDOMETRIOSIS; ENZYME INHIBITORS; ESTRADIOL; ESTROGENS; ESTRONE; FEMALE; GENE EXPRESSION; GONADOTROPIN-RELEASING HORMONE; HUMANS; MODELS, BIOLOGICAL; MULLERIAN DUCTS; RNA, MESSENGER; STROMAL CELLS;

EID: 0035716594     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00134-0     Document Type: Conference Paper

References (31)

1. Epidemiology of endometriosis in women attending family planning clinics
2. Chronic gynecological conditions reported by US women: Findings from the National Health Information Survey, 1984-1992
3. Endometriosis
4. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity
5. Peritoneal macrophages from patients with endometriosis release growth factor activity in vitro
6. Aromatase expression in endometriosis
7. Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of SF-1 and COUP-TF to the same cis-acting element
8. Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis
9. Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1)
10. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice
11. Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis
12. Deficient 17β-hydroxysteroid dehydrogenase type 2 expression in endometriosis: Failure to metabolize estradiol-17β
13. A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene
14. Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary
15. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis
16. Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture
17. 4-androstenedione to estrone in normal males and non-pregnant normal, castrate and adrenalectomized females
18. Effect of obesity on conversion of plasma androstenedione to estrone in post-menopausal women with and without endometrial cancer
19. A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription
20. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation
21. Expression of the CYP19 gene and its product aromatase cytochrome P450 in human leiomyoma tissues and cells in culture
22. 2 stimulates aromatase expression in endometriosis-derived stromal cells
23. Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua
24. Regulation of cyclo-oxygenase-2 gene in cultured endometrial stromal cells by sex steroids
25. Immunology and endometriosis
26. Treatment of severe post-menopausal endometriosis with an aromatase inhibitor
27. Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases
28. Distribution of progesterone receptor, estradiol dehydrogenase, and 20α-dihydroprogesterone dehydrogenase activities in human endometrial glands and stroma: Progestin induction of steroid dehydrogenase activities in vitro is restricted to the glandular epithelium
29. Administration of nasal nafarelin as compared with oral danazol for endometriosis
30. Gonadotropin-releasing hormone analogues for the treatment of endometriosis: Long-term follow-up
31. Hormone-resistant endometriosis following total abdominal hysterectomy and bilateral salpingo-oophorectomy: Correlation with histology and steroid receptor content