메뉴 건너뛰기




Volumn 38, Issue 1, 2013, Pages 19-25

Recent advances in chemistry and biology of gamboge

Author keywords

, unsaturated ketone; Antitumor; Gamboge; Gambogic acid; Metabolism; Michael addition reaction; Sulfonation; Target protein

Indexed keywords

ANTINEOPLASTIC AGENT; GAMBOGE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

EID: 84877074105     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20130105     Document Type: Review
Times cited : (5)

References (77)
  • 1
    • 70450197675 scopus 로고    scopus 로고
    • Caged Garcinia xanthones: development since 1937
    • Han Q B, Xu H X. Caged Garcinia xanthones: development since 1937 [J]. Curr Med Chem, 2009, 16 (28): 3775.
    • (2009) Curr Med Chem , vol.16 , Issue.28 , pp. 3775
    • Han, Q.B.1    Xu, H.X.2
  • 2
    • 84877040011 scopus 로고
    • Chinese source
    • 1982 (3): 1.
    • (1982) , Issue.3 , pp. 1
  • 3
    • 84877081934 scopus 로고
    • Chinese source
    • 1981, 8 (4): 230.
    • (1981) , vol.8 , Issue.4 , pp. 230
  • 4
    • 84877059076 scopus 로고
    • Chinese source
    • 1986, 13 (2): 111.
    • (1986) , vol.13 , Issue.2 , pp. 111
  • 5
    • 84877058122 scopus 로고
    • Chinese source
    • 1986 (3): 46.
    • (1986) , Issue.3 , pp. 46
  • 6
    • 84877030972 scopus 로고
    • Chinese source
    • 1986 (1): 31.
    • (1986) , Issue.1 , pp. 31
  • 7
    • 84877018324 scopus 로고    scopus 로고
    • Chinese source
    • 2003, 10 (2): 216.
    • (2003) , vol.10 , Issue.2 , pp. 216
  • 8
    • 2942629656 scopus 로고    scopus 로고
    • General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice
    • Guo Q L, You Q D, Wu Z Q, et al. General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice [J]. Acta Pharmacol Sin, 2004, 25 (6): 769.
    • (2004) Acta Pharmacol Sin , vol.25 , Issue.6 , pp. 769
    • Guo, Q.L.1    You, Q.D.2    Wu, Z.Q.3
  • 9
    • 32044466747 scopus 로고    scopus 로고
    • Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
    • Han Q B, Wang Y L, Yang L, et al. Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi [J]. Chem Pharm Bull, 2006, 54 (2): 265.
    • (2006) Chem Pharm Bull , vol.54 , Issue.2 , pp. 265
    • Han, Q.B.1    Wang, Y.L.2    Yang, L.3
  • 10
    • 0030087854 scopus 로고    scopus 로고
    • Cytotoxic xanthones from Garcinia hanburyi
    • Asano J, Chiba K, Tada M, et al. Cytotoxic xanthones from Garcinia hanburyi[J]. Phytochemistry, 1996, 41(3): 815.
    • (1996) Phytochemistry , vol.41 , Issue.3 , pp. 815
    • Asano, J.1    Chiba, K.2    Tada, M.3
  • 11
    • 84877025632 scopus 로고
    • Chinese source
    • 1980 (2): 1.
    • (1980) , Issue.2 , pp. 1
  • 12
    • 84877039752 scopus 로고    scopus 로고
    • Chinese source
    • 2008, 66 (22): 2513.
    • (2008) , vol.66 , Issue.22 , pp. 2513
  • 13
    • 60549086634 scopus 로고    scopus 로고
    • Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
    • Tao S J, Guan S H, Wang W, et al. Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi [J]. J Nat Prod, 2009, 72(1): 117.
    • (2009) J Nat Prod , vol.72 , Issue.1 , pp. 117
    • Tao, S.J.1    Guan, S.H.2    Wang, W.3
  • 14
    • 84877018912 scopus 로고    scopus 로고
    • Chinese source
    • 2008, 43(8): 838.
    • (2008) , vol.43 , Issue.8 , pp. 838
  • 15
    • 53649099787 scopus 로고    scopus 로고
    • Analysis of caged xanthones from the resin of Garcinia hanburyi using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry
    • Zhou Y, Liu X, Yang J, et al. Analysis of caged xanthones from the resin of Garcinia hanburyi using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry [J]. Anal Chim Acta, 2008, 629(1/2): 104.
    • (2008) Anal Chim Acta , vol.629 , Issue.1-2 , pp. 104
    • Zhou, Y.1    Liu, X.2    Yang, J.3
  • 16
    • 83955161071 scopus 로고    scopus 로고
    • Rapid characterization of caged xanthones in the resin of Garcinia hanburyi using multiple mass spectrometric scanning modes: the importance of biosynthetic knowledge based prediction
    • Yang J, Ding L, Hu L, et al. Rapid characterization of caged xanthones in the resin of Garcinia hanburyi using multiple mass spectrometric scanning modes: the importance of biosynthetic knowledge based prediction [J]. J Pharm Biomed Anal, 2012, 60(4): 71.
    • (2012) J Pharm Biomed Anal , vol.60 , Issue.4 , pp. 71
    • Yang, J.1    Ding, L.2    Hu, L.3
  • 17
    • 33645011267 scopus 로고    scopus 로고
    • Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi
    • Han Q, Yang L, Liu Y, et al. Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi[J]. Planta Med, 2006, 72(3): 281.
    • (2006) Planta Med , vol.72 , Issue.3 , pp. 281
    • Han, Q.1    Yang, L.2    Liu, Y.3
  • 18
    • 36249016871 scopus 로고    scopus 로고
    • Five novel prenylated xanthones from Resina Garciniae
    • Feng F, Liu W Y, Chen Y S, et al. Five novel prenylated xanthones from Resina Garciniae [J]. J Asian Nat Prod Res, 2007, 9(6/8): 735.
    • (2007) J Asian Nat Prod Res , vol.9 , Issue.6-8 , pp. 735
    • Feng, F.1    Liu, W.Y.2    Chen, Y.S.3
  • 19
    • 84989029929 scopus 로고
    • Isogambogic acid and isomorellinol from Garcinia hanburyi
    • Lin L J, Lin L Z, Pezzuto J M, et al. Isogambogic acid and isomorellinol from Garcinia hanburyi [J]. Magn Reson Chem, 1993, 31: 340.
    • (1993) Magn Reson Chem , vol.31 , pp. 340
    • Lin, L.J.1    Lin, L.Z.2    Pezzuto, J.M.3
  • 20
    • 33748087815 scopus 로고    scopus 로고
    • Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography
    • Han Q B, Song J Z, Qiao C F, et al. Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography [J]. J Chromatogr A, 2006, 1127(1/2): 298.
    • (2006) J Chromatogr A , vol.1127 , Issue.1-2 , pp. 298
    • Han, Q.B.1    Song, J.Z.2    Qiao, C.F.3
  • 21
    • 31544434864 scopus 로고    scopus 로고
    • A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges
    • Han Q B, Yang L, Wang Y L, et al. A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges [J]. Chem Biodivers, 2006, 3(1): 101.
    • (2006) Chem Biodivers , vol.3 , Issue.1 , pp. 101
    • Han, Q.B.1    Yang, L.2    Wang, Y.L.3
  • 22
    • 38949176773 scopus 로고    scopus 로고
    • Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study
    • Qiang L, Yang Y, You Q D, et al. Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study [J]. Biochem Pharmacol, 2008, 75(5): 1083.
    • (2008) Biochem Pharmacol , vol.75 , Issue.5 , pp. 1083
    • Qiang, L.1    Yang, Y.2    You, Q.D.3
  • 23
    • 35348952483 scopus 로고    scopus 로고
    • Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
    • Lu N, Yang Y, You Q D, et al. Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1 [J]. Cancer Lett, 2007, 258(1): 80.
    • (2007) Cancer Lett , vol.258 , Issue.1 , pp. 80
    • Lu, N.1    Yang, Y.2    You, Q.D.3
  • 24
    • 77956106042 scopus 로고    scopus 로고
    • Chemistry and biology of the caged Garcinia xanthones
    • Chantarasriwong O, Batova A, Chavasiri W, et al. Chemistry and biology of the caged Garcinia xanthones [J]. Chemistry, 2010, 16(33): 9944.
    • (2010) Chemistry , vol.16 , Issue.33 , pp. 9944
    • Chantarasriwong, O.1    Batova, A.2    Chavasiri, W.3
  • 25
    • 84877076081 scopus 로고    scopus 로고
    • Chinese source
    • 2011, 35(8): 337.
    • (2011) , vol.35 , Issue.8 , pp. 337
  • 26
    • 84877047255 scopus 로고    scopus 로고
    • Chinese source
    • 2006, 4(3): 2210.
    • (2006) , vol.4 , Issue.3 , pp. 2210
  • 27
    • 79952283088 scopus 로고    scopus 로고
    • Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity
    • Wang X, Lu N, Yang Q, et al. Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity [J]. Eur J Med Chem, 2011, 46(4): 1280.
    • (2011) Eur J Med Chem , vol.46 , Issue.4 , pp. 1280
    • Wang, X.1    Lu, N.2    Yang, Q.3
  • 28
    • 20344405555 scopus 로고    scopus 로고
    • Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells
    • Wu Z Q, Guo Q L, You Q D, et al. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells [J]. Biol Pharm Bull, 2004, 27(11): 1769.
    • (2004) Biol Pharm Bull , vol.27 , Issue.11 , pp. 1769
    • Wu, Z.Q.1    Guo, Q.L.2    You, Q.D.3
  • 29
    • 9644266405 scopus 로고    scopus 로고
    • Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells
    • Zhao L, Guo Q L, You Q D, et al. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells [J]. Biol Pharm Bull, 2004, 27(7): 998.
    • (2004) Biol Pharm Bull , vol.27 , Issue.7 , pp. 998
    • Zhao, L.1    Guo, Q.L.2    You, Q.D.3
  • 30
    • 23844463880 scopus 로고    scopus 로고
    • Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823
    • Liu W, Guo Q L, You Q D, et al. Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823 [J]. World J Gastroenterol, 2005, 11(24): 3655.
    • (2005) World J Gastroenterol , vol.11 , Issue.24 , pp. 3655
    • Liu, W.1    Guo, Q.L.2    You, Q.D.3
  • 31
    • 31844434032 scopus 로고    scopus 로고
    • Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells
    • Guo Q L, Lin S S, You Q D, et al. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells [J]. Life Sci, 2006, 78(11): 1238.
    • (2006) Life Sci , vol.78 , Issue.11 , pp. 1238
    • Guo, Q.L.1    Lin, S.S.2    You, Q.D.3
  • 32
    • 33745698235 scopus 로고    scopus 로고
    • Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells
    • Yu J, Guo Q L, You Q D, et al. Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells [J]. Cancer Chemother Pharmacol, 2006, 58(4): 434.
    • (2006) Cancer Chemother Pharmacol , vol.58 , Issue.4 , pp. 434
    • Yu, J.1    Guo, Q.L.2    You, Q.D.3
  • 33
    • 34047133853 scopus 로고    scopus 로고
    • Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells
    • Yu J, Guo Q L, You Q D, et al. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells [J]. Carcinogenesis, 2007, 28(3): 632.
    • (2007) Carcinogenesis , vol.28 , Issue.3 , pp. 632
    • Yu, J.1    Guo, Q.L.2    You, Q.D.3
  • 34
    • 46449099079 scopus 로고    scopus 로고
    • Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells
    • Chen J, Gu H Y, Lu N, et al. Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells [J]. Life Sci, 2008, 83 (3/4): 103.
    • (2008) Life Sci , vol.83 , Issue.3-4 , pp. 103
    • Chen, J.1    Gu, H.Y.2    Lu, N.3
  • 35
    • 55749086025 scopus 로고    scopus 로고
    • Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells
    • Gu H, Wang X, Rao S, et al. Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells [J]. Mol Cancer Ther, 2008, 7 (10): 3298.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3298
    • Gu, H.1    Wang, X.2    Rao, S.3
  • 36
    • 51749101694 scopus 로고    scopus 로고
    • Gambogic acid induced tumor cell apoptosis by T-lymphocyte activation in H22 transplanted mice
    • Gu H, You Q, Liu W, et al. Gambogic acid induced tumor cell apoptosis by T-lymphocyte activation in H22 transplanted mice [J]. Int Immunopharmacol, 2008, 8(11): 1493.
    • (2008) Int Immunopharmacol , vol.8 , Issue.11 , pp. 1493
    • Gu, H.1    You, Q.2    Liu, W.3
  • 37
    • 56949096780 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis
    • Qi Q, Gu H, Yang Y, et al. Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis [J]. J Mol Med (Berl), 2008, 86(12): 1367.
    • (2008) J Mol Med (Berl) , vol.86 , Issue.12 , pp. 1367
    • Qi, Q.1    Gu, H.2    Yang, Y.3
  • 38
    • 54249137412 scopus 로고    scopus 로고
    • Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells
    • Qi Q, Lu N, Wang X T, et al. Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells [J]. Biochem Cell Biol, 2008, 86(5): 386.
    • (2008) Biochem Cell Biol , vol.86 , Issue.5 , pp. 386
    • Qi, Q.1    Lu, N.2    Wang, X.T.3
  • 39
    • 47549099788 scopus 로고    scopus 로고
    • Inhibition of alpha (4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid
    • Zhao J, Qi Q, Yang Y, et al. Inhibition of alpha (4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid [J]. Eur J Pharmacol, 2008, 589(1/3): 127.
    • (2008) Eur J Pharmacol , vol.589 , Issue.1-3 , pp. 127
    • Zhao, J.1    Qi, Q.2    Yang, Y.3
  • 40
    • 40649108043 scopus 로고    scopus 로고
    • Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells
    • Zhao Q, Yang Y, Yu J, et al. Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells [J]. Cancer Lett, 2008, 262(2): 223.
    • (2008) Cancer Lett , vol.262 , Issue.2 , pp. 223
    • Zhao, Q.1    Yang, Y.2    Yu, J.3
  • 41
    • 70349773507 scopus 로고    scopus 로고
    • Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells
    • Gu H, Rao S, Zhao J, et al. Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells [J]. J Cancer Res Clin Oncol, 2009, 135(12): 1777.
    • (2009) J Cancer Res Clin Oncol , vol.135 , Issue.12 , pp. 1777
    • Gu, H.1    Rao, S.2    Zhao, J.3
  • 42
    • 67349089550 scopus 로고    scopus 로고
    • Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells
    • Nie F, Zhang X, Qi Q, et al. Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells [J]. Toxicology, 2009, 260(1/3): 60.
    • (2009) Toxicology , vol.260 , Issue.1-3 , pp. 60
    • Nie, F.1    Zhang, X.2    Qi, Q.3
  • 43
    • 69049088724 scopus 로고    scopus 로고
    • Gambogic acid down-regulates MDM2 oncogene and induces p21 (Waf1/CIP1) expression independent of p53
    • Rong J J, Hu R, Qi Q, et al. Gambogic acid down-regulates MDM2 oncogene and induces p21 (Waf1/CIP1) expression independent of p53 [J]. Cancer Lett, 2009, 284(1): 102.
    • (2009) Cancer Lett , vol.284 , Issue.1 , pp. 102
    • Rong, J.J.1    Hu, R.2    Qi, Q.3
  • 44
    • 77954761399 scopus 로고    scopus 로고
    • Gambogic acid triggers DNA damage signaling that induces p53/p21 (Waf1/CIP1) activation through the ATR-Chk1 pathway
    • Rong J J, Hu R, Song X M, et al. Gambogic acid triggers DNA damage signaling that induces p53/p21 (Waf1/CIP1) activation through the ATR-Chk1 pathway [J]. Cancer Lett, 2010, 296 (1): 55.
    • (2010) Cancer Lett , vol.296 , Issue.1 , pp. 55
    • Rong, J.J.1    Hu, R.2    Song, X.M.3
  • 45
    • 79251631447 scopus 로고    scopus 로고
    • Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP
    • Wang J, Zhao Q, Qi Q, et al. Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP [J]. J Cell Biochem, 2011, 112(2): 509.
    • (2011) J Cell Biochem , vol.112 , Issue.2 , pp. 509
    • Wang, J.1    Zhao, Q.2    Qi, Q.3
  • 46
    • 80555131105 scopus 로고    scopus 로고
    • Gambogic acid inhibits tumor cell adhesion by suppressing integrin beta1 and membrane lipid rafts-associated integrin signaling pathway
    • Li C, Lu N, Qi Q, et al. Gambogic acid inhibits tumor cell adhesion by suppressing integrin beta1 and membrane lipid rafts-associated integrin signaling pathway [J]. Biochem Pharmacol, 2011, 82(12): 1873.
    • (2011) Biochem Pharmacol , vol.82 , Issue.12 , pp. 1873
    • Li, C.1    Lu, N.2    Qi, Q.3
  • 47
    • 34748925888 scopus 로고    scopus 로고
    • Gambogic acid inhibits the catalytic activity of human topoisomerase II alpha by binding to its AT-Pase domain
    • Qin Y, Meng L, Hu C, et al. Gambogic acid inhibits the catalytic activity of human topoisomerase II alpha by binding to its AT-Pase domain [J]. Mol Cancer Ther, 2007, 6(9): 2429.
    • (2007) Mol Cancer Ther , vol.6 , Issue.9 , pp. 2429
    • Qin, Y.1    Meng, L.2    Hu, C.3
  • 48
    • 24744435348 scopus 로고    scopus 로고
    • A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid
    • Kasibhatla S, Jessen K A, Maliartchouk S, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid [J]. Proc Natl Acad Sci USA, 2005, 102 (34): 12095.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.34 , pp. 12095
    • Kasibhatla, S.1    Jessen, K.A.2    Maliartchouk, S.3
  • 49
    • 49849094579 scopus 로고    scopus 로고
    • Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins
    • Zhai D, Jin C, Shiau C W, et al. Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins [J]. Mol Cancer Ther, 2008, 7(6): 1639.
    • (2008) Mol Cancer Ther , vol.7 , Issue.6 , pp. 1639
    • Zhai, D.1    Jin, C.2    Shiau, C.W.3
  • 50
    • 35349029248 scopus 로고    scopus 로고
    • Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway
    • Pandey M K, Sung B, Ahn K S, et al. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway [J]. Blood, 2007, 110(10): 3517.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3517
    • Pandey, M.K.1    Sung, B.2    Ahn, K.S.3
  • 51
    • 84877041356 scopus 로고    scopus 로고
    • Chinese source
    • 2007, 16 (1): 79.
    • (2007) , vol.16 , Issue.1 , pp. 79
  • 52
    • 34548679604 scopus 로고    scopus 로고
    • Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes
    • Yang Y, Yang L, You Q D, et al. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes [J]. Cancer Lett, 2007, 256(2): 259.
    • (2007) Cancer Lett , vol.256 , Issue.2 , pp. 259
    • Yang, Y.1    Yang, L.2    You, Q.D.3
  • 53
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation [J]. Cell, 2011, 144(5): 646.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646
    • Hanahan, D.1    Weinberg, R.A.2
  • 54
    • 84859610927 scopus 로고    scopus 로고
    • Gambogic acid inhibits TNF-alpha-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-kappaB signaling pathways
    • Lu L, Tang D, Wang L, et al. Gambogic acid inhibits TNF-alpha-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-kappaB signaling pathways [J]. Acta Pharmacol Sin, 2012, 33(4):531.
    • (2012) Acta Pharmacol Sin , vol.33 , Issue.4 , pp. 531
    • Lu, L.1    Tang, D.2    Wang, L.3
  • 55
    • 40949101023 scopus 로고    scopus 로고
    • Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling
    • Yi T, Yi Z, Cho S G, et al. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling [J]. Cancer Res, 2008, 68 (6): 1843.
    • (2008) Cancer Res , vol.68 , Issue.6 , pp. 1843
    • Yi, T.1    Yi, Z.2    Cho, S.G.3
  • 56
    • 67649995348 scopus 로고    scopus 로고
    • 1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells
    • 1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells [J]. Toxicology, 2009, 262(2): 98.
    • (2009) Toxicology , vol.262 , Issue.2 , pp. 98
    • Li, R.1    Chen, Y.2    Zeng, L.L.3
  • 57
    • 77958573005 scopus 로고    scopus 로고
    • 1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor beta tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells
    • 1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor beta tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells [J]. J Atheroscler Thromb, 2010, 17 (9): 901.
    • (2010) J Atheroscler Thromb , vol.17 , Issue.9 , pp. 901
    • Liu, Y.1    Li, W.2    Ye, C.3
  • 58
    • 79953030677 scopus 로고    scopus 로고
    • Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest
    • Zhao W, Zhou S F, Zhang Z P, et al. Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest [J]. Oncol Rep, 2011, 25(2):1289.
    • (2011) Oncol Rep , vol.25 , Issue.2 , pp. 1289
    • Zhao, W.1    Zhou, S.F.2    Zhang, Z.P.3
  • 59
    • 64249171904 scopus 로고    scopus 로고
    • Gambogic acid covalently modifies I kappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophages
    • Palempalli U D, Gandhi U, Kalantari P, et al. Gambogic acid covalently modifies I kappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophages [J]. Biochem J, 2009, 419(2): 401.
    • (2009) Biochem J , vol.419 , Issue.2 , pp. 401
    • Palempalli, U.D.1    Gandhi, U.2    Kalantari, P.3
  • 60
    • 34047249406 scopus 로고    scopus 로고
    • Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f
    • Panthong A, Norkaew P, Kanjanapothi D, et al. Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f [J]. J Ethnopharmacol, 2007, 111(2): 335.
    • (2007) J Ethnopharmacol , vol.111 , Issue.2 , pp. 335
    • Panthong, A.1    Norkaew, P.2    Kanjanapothi, D.3
  • 61
    • 78650173496 scopus 로고    scopus 로고
    • Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells
    • Zhang L, Yi Y, Chen J, et al. Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells [J]. Biochem Biophys Res Commun, 2010, 403(3/4): 282.
    • (2010) Biochem Biophys Res Commun , vol.403 , Issue.3-4 , pp. 282
    • Zhang, L.1    Yi, Y.2    Chen, J.3
  • 62
    • 77957707135 scopus 로고    scopus 로고
    • Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma
    • Yang J, Ding L, Hu L, et al. Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma [J]. Eur J Mass Spectrom, 2010, 16(5): 605.
    • (2010) Eur J Mass Spectrom , vol.16 , Issue.5 , pp. 605
    • Yang, J.1    Ding, L.2    Hu, L.3
  • 63
    • 84857868182 scopus 로고    scopus 로고
    • Application of the hard and soft, acids and bases (HSAB) theory to toxicant-target interactions
    • Lopachin R M, Gavin T, Decaprio A, et al. Application of the hard and soft, acids and bases (HSAB) theory to toxicant-target interactions [J]. Chem Res Toxicol, 2012, 25(2): 239.
    • (2012) Chem Res Toxicol , vol.25 , Issue.2 , pp. 239
    • Lopachin, R.M.1    Gavin, T.2    Decaprio, A.3
  • 64
    • 78650078496 scopus 로고    scopus 로고
    • Quantitative reactivity profiling predicts functional cysteines in proteomes
    • Weerapana E, Wang C, Simon G M, et al. Quantitative reactivity profiling predicts functional cysteines in proteomes [J]. Nature, 2010, 468(7325): 790.
    • (2010) Nature , vol.468 , Issue.7325 , pp. 790
    • Weerapana, E.1    Wang, C.2    Simon, G.M.3
  • 65
    • 84866463546 scopus 로고    scopus 로고
    • Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain
    • Yang J, Li C, Ding L, et al. Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain [J]. J Nat Prod, 2012, 75(6): 1108.
    • (2012) J Nat Prod , vol.75 , Issue.6 , pp. 1108
    • Yang, J.1    Li, C.2    Ding, L.3
  • 66
    • 79960972278 scopus 로고    scopus 로고
    • Natural products as catalysts for innovation: a pharmaceutical industry perspective
    • Schmitt E K, Moore C M, Krastel P, et al. Natural products as catalysts for innovation: a pharmaceutical industry perspective [J]. Curr Opin Chem Biol, 2011, 15(4): 497.
    • (2011) Curr Opin Chem Biol , vol.15 , Issue.4 , pp. 497
    • Schmitt, E.K.1    Moore, C.M.2    Krastel, P.3
  • 67
    • 77950493758 scopus 로고    scopus 로고
    • Natural products and their biological targets: proteomic and metabolomic labeling strategies
    • Bottcher T, Pitscheider M, Sieber S A. Natural products and their biological targets: proteomic and metabolomic labeling strategies [J]. Angew Chem Int Ed Engl, 2010, 49(15): 2680.
    • (2010) Angew Chem Int Ed Engl , vol.49 , Issue.15 , pp. 2680
    • Bottcher, T.1    Pitscheider, M.2    Sieber, S.A.3
  • 68
    • 66149117502 scopus 로고    scopus 로고
    • Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
    • Codreanu S G, Zhang B, Sobecki S M, et al. Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal [J]. Mol Cell Proteomics, 2009, 8(4): 670.
    • (2009) Mol Cell Proteomics , vol.8 , Issue.4 , pp. 670
    • Codreanu, S.G.1    Zhang, B.2    Sobecki, S.M.3
  • 69
    • 77952650680 scopus 로고    scopus 로고
    • Systems analysis of protein modification and cellular responses induced by electrophile stress
    • Jacobs A T, Marnett L J. Systems analysis of protein modification and cellular responses induced by electrophile stress [J]. Acc Chem Res, 2010, 43(5): 673.
    • (2010) Acc Chem Res , vol.43 , Issue.5 , pp. 673
    • Jacobs, A.T.1    Marnett, L.J.2
  • 70
    • 84877067875 scopus 로고
    • Chinese source
    • 1989(3): 9.
    • (1989) , Issue.3 , pp. 9
  • 71
    • 84877042009 scopus 로고    scopus 로고
    • Chinese source
    • 2005, 36(4): 338.
    • (2005) , vol.36 , Issue.4 , pp. 338
  • 72
    • 34547609631 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats
    • Hao K, Liu X Q, Wang G J, et al. Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats [J]. Eur J Drug Metab Pharmacokinet, 2007, 32(2): 63.
    • (2007) Eur J Drug Metab Pharmacokinet , vol.32 , Issue.2 , pp. 63
    • Hao, K.1    Liu, X.Q.2    Wang, G.J.3
  • 73
    • 33947593843 scopus 로고    scopus 로고
    • Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study
    • Hao K, Zhao X P, Liu X Q, et al. Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study [J]. Biomed Chromatogr, 2007, 21 (3): 279.
    • (2007) Biomed Chromatogr , vol.21 , Issue.3 , pp. 279
    • Hao, K.1    Zhao, X.P.2    Liu, X.Q.3
  • 74
    • 77957707135 scopus 로고    scopus 로고
    • Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma
    • Yang J, Ding L, Hu L, et al. Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma [J]. Eur J Mass Spectrom, 2010, 16(5): 605.
    • (2010) Eur J Mass Spectrom , vol.16 , Issue.5 , pp. 605
    • Yang, J.1    Ding, L.2    Hu, L.3
  • 75
    • 36549089934 scopus 로고    scopus 로고
    • Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-nuclear magnetic resonance
    • Feng F, Liu W, Wang Y, et al. Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-nuclear magnetic resonance [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 860(2): 218.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.860 , Issue.2 , pp. 218
    • Feng, F.1    Liu, W.2    Wang, Y.3
  • 76
    • 76549088931 scopus 로고    scopus 로고
    • Identification of gambogic acid metabolites in rat bile by liquid chromatography-tandem mass spectrometry-ion trap-time-of-flight
    • Zhang L, You Q, Liang Y, et al. Identification of gambogic acid metabolites in rat bile by liquid chromatography-tandem mass spectrometry-ion trap-time-of-flight [J]. Chin J Nat Med, 2009, 7(5): 376.
    • (2009) Chin J Nat Med , vol.7 , Issue.5 , pp. 376
    • Zhang, L.1    You, Q.2    Liang, Y.3
  • 77
    • 79952852572 scopus 로고    scopus 로고
    • Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition
    • Yang J, Ding L, Hu L, et al. Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition [J]. Drug Metab Dispos, 2011, 39(4): 617.
    • (2011) Drug Metab Dispos , vol.39 , Issue.4 , pp. 617
    • Yang, J.1    Ding, L.2    Hu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.