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Volumn 262, Issue 2, 2008, Pages 223-231

Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells

Author keywords

Akt; c Myc; Gambogic acid; Gastric carcinoma; Telomerase hTERT

Indexed keywords

CELECOXIB; GAMBOGIC ACID; MYC PROTEIN; PROTEIN KINASE B; SMALL INTERFERING RNA; TELOMERASE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 40649108043     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.12.002     Document Type: Article
Times cited : (48)

References (30)
  • 1
    • 84980111516 scopus 로고
    • The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin
    • Liesenklas W., and Auterhoff H. The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin. Arch. Pharm. Ber. Dtsch. Pharm. Ges. 299 (1966) 797-798
    • (1966) Arch. Pharm. Ber. Dtsch. Pharm. Ges. , vol.299 , pp. 797-798
    • Liesenklas, W.1    Auterhoff, H.2
  • 2
    • 0021478740 scopus 로고
    • Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi)
    • Lu G.B., Yang X.X., and Huang Q.S. Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi). Yao Xue Xue Bao 19 (1984) 636-639
    • (1984) Yao Xue Xue Bao , vol.19 , pp. 636-639
    • Lu, G.B.1    Yang, X.X.2    Huang, Q.S.3
  • 3
    • 9644266405 scopus 로고    scopus 로고
    • Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells
    • Zhao L., Guo Q.L., You Q.D., Wu Z.Q., and Gu H.Y. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol. Pharm. Bull. 27 (2004) 998-1003
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 998-1003
    • Zhao, L.1    Guo, Q.L.2    You, Q.D.3    Wu, Z.Q.4    Gu, H.Y.5
  • 4
    • 20344405555 scopus 로고    scopus 로고
    • Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells
    • Wu Z.Q., Guo Q.L., You Q.D., Zhao L., and Gu H.Y. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol. Pharm. Bull. 27 (2004) 1769-1774
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 1769-1774
    • Wu, Z.Q.1    Guo, Q.L.2    You, Q.D.3    Zhao, L.4    Gu, H.Y.5
  • 6
    • 34047133853 scopus 로고    scopus 로고
    • Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells
    • Yu J., Guo Q.L., You Q.D., Zhao L., Gu H.Y., Yang Y., Zhang H.W., Tan Z., and Wang X. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis 28 (2007) 632-638
    • (2007) Carcinogenesis , vol.28 , pp. 632-638
    • Yu, J.1    Guo, Q.L.2    You, Q.D.3    Zhao, L.4    Gu, H.Y.5    Yang, Y.6    Zhang, H.W.7    Tan, Z.8    Wang, X.9
  • 7
    • 34548679604 scopus 로고    scopus 로고
    • Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes
    • Yang Y., Yang L., You Q.D., Nie F.F., Gu H.Y., Zhao L., Wang X.T., and Guo Q.L. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Lett. 256 (2007) 259-266
    • (2007) Cancer Lett. , vol.256 , pp. 259-266
    • Yang, Y.1    Yang, L.2    You, Q.D.3    Nie, F.F.4    Gu, H.Y.5    Zhao, L.6    Wang, X.T.7    Guo, Q.L.8
  • 9
    • 0037114491 scopus 로고    scopus 로고
    • Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis
    • Liu W.J., Jiang J.F., Xiao D., and Ding J. Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Biochem. Pharmacol. 64 (2002) 1677-1687
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1677-1687
    • Liu, W.J.1    Jiang, J.F.2    Xiao, D.3    Ding, J.4
  • 10
    • 0033609046 scopus 로고    scopus 로고
    • Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
    • Liu K., Schoonmaker M.M., Levine B.L., June C.H., Hodes R.J., and Weng N.P. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 5147-5152
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5147-5152
    • Liu, K.1    Schoonmaker, M.M.2    Levine, B.L.3    June, C.H.4    Hodes, R.J.5    Weng, N.P.6
  • 12
    • 0033571329 scopus 로고    scopus 로고
    • Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors
    • Wu A., Ichihashi M., and Ueda M. Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors. Cancer 86 (1999) 2038-2044
    • (1999) Cancer , vol.86 , pp. 2038-2044
    • Wu, A.1    Ichihashi, M.2    Ueda, M.3
  • 13
    • 0037223887 scopus 로고    scopus 로고
    • Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter
    • Renaud S., Bosman F.T., and Benhattar J. Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. Biochem. Biophys. Res. Commun. 300 (2003) 47-54
    • (2003) Biochem. Biophys. Res. Commun. , vol.300 , pp. 47-54
    • Renaud, S.1    Bosman, F.T.2    Benhattar, J.3
  • 14
    • 0035871710 scopus 로고    scopus 로고
    • Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
    • Liu K., Hodes R.J., and Weng N. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166 (2001) 4826-4830
    • (2001) J. Immunol. , vol.166 , pp. 4826-4830
    • Liu, K.1    Hodes, R.J.2    Weng, N.3
  • 15
    • 33745698235 scopus 로고    scopus 로고
    • Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells
    • Yu J., Guo Q.L., You Q.D., Lin S.S., Li Z., Gu H.Y., Zhang H.W., Tan Z., and Wang X. Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. Cancer Chemother. Pharmacol. 58 (2006) 434-443
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 434-443
    • Yu, J.1    Guo, Q.L.2    You, Q.D.3    Lin, S.S.4    Li, Z.5    Gu, H.Y.6    Zhang, H.W.7    Tan, Z.8    Wang, X.9
  • 16
    • 31844434032 scopus 로고    scopus 로고
    • Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells
    • Guo Q.L., Lin S.S., You Q.D., Gu H.Y., Yu J., Zhao L., Qi Q., Liang F., Tan Z., and Wang X. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci. 78 (2006) 1238-1245
    • (2006) Life Sci. , vol.78 , pp. 1238-1245
    • Guo, Q.L.1    Lin, S.S.2    You, Q.D.3    Gu, H.Y.4    Yu, J.5    Zhao, L.6    Qi, Q.7    Liang, F.8    Tan, Z.9    Wang, X.10
  • 17
    • 5444259727 scopus 로고    scopus 로고
    • Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells
    • Wang Q., Bai Z.L., Xuan L., Hou L., and Zhang B. Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells. Chin. Med. Sci. J. 19 (2004) 157-163
    • (2004) Chin. Med. Sci. J. , vol.19 , pp. 157-163
    • Wang, Q.1    Bai, Z.L.2    Xuan, L.3    Hou, L.4    Zhang, B.5
  • 19
    • 33644512054 scopus 로고    scopus 로고
    • Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells
    • Jagadeesh S., Kyo S., and Banerjee P.P. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res. 66 (2006) 2107-2115
    • (2006) Cancer Res. , vol.66 , pp. 2107-2115
    • Jagadeesh, S.1    Kyo, S.2    Banerjee, P.P.3
  • 24
    • 19544385752 scopus 로고    scopus 로고
    • Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention
    • Ang K.L., Shi D.L., Keong W.W., and Epstein R.J. Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention. Cancer Lett. 225 (2005) 53-59
    • (2005) Cancer Lett. , vol.225 , pp. 53-59
    • Ang, K.L.1    Shi, D.L.2    Keong, W.W.3    Epstein, R.J.4
  • 25
    • 0033532056 scopus 로고    scopus 로고
    • Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
    • Kang S.S., Kwon T., Kwon D.Y., and Do S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274 (1999) 13085-13090
    • (1999) J. Biol. Chem. , vol.274 , pp. 13085-13090
    • Kang, S.S.1    Kwon, T.2    Kwon, D.Y.3    Do, S.I.4
  • 26
    • 38049112379 scopus 로고    scopus 로고
    • Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma Cells
    • Bu X., Jia F., Wang W., Guo X., Wu M., and Wei L. Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma Cells. BMC Cancer 7 (2007) 208
    • (2007) BMC Cancer , vol.7 , pp. 208
    • Bu, X.1    Jia, F.2    Wang, W.3    Guo, X.4    Wu, M.5    Wei, L.6
  • 29
    • 17844380300 scopus 로고    scopus 로고
    • IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
    • Kawauchi K., Ihjima K., and Yamada O. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. J. Immunol. 174 (2005) 5261-5269
    • (2005) J. Immunol. , vol.174 , pp. 5261-5269
    • Kawauchi, K.1    Ihjima, K.2    Yamada, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.