-
1
-
-
84980111516
-
The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin
-
Liesenklas W., and Auterhoff H. The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin. Arch. Pharm. Ber. Dtsch. Pharm. Ges. 299 (1966) 797-798
-
(1966)
Arch. Pharm. Ber. Dtsch. Pharm. Ges.
, vol.299
, pp. 797-798
-
-
Liesenklas, W.1
Auterhoff, H.2
-
2
-
-
0021478740
-
Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi)
-
Lu G.B., Yang X.X., and Huang Q.S. Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi). Yao Xue Xue Bao 19 (1984) 636-639
-
(1984)
Yao Xue Xue Bao
, vol.19
, pp. 636-639
-
-
Lu, G.B.1
Yang, X.X.2
Huang, Q.S.3
-
3
-
-
9644266405
-
Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells
-
Zhao L., Guo Q.L., You Q.D., Wu Z.Q., and Gu H.Y. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol. Pharm. Bull. 27 (2004) 998-1003
-
(2004)
Biol. Pharm. Bull.
, vol.27
, pp. 998-1003
-
-
Zhao, L.1
Guo, Q.L.2
You, Q.D.3
Wu, Z.Q.4
Gu, H.Y.5
-
4
-
-
20344405555
-
Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells
-
Wu Z.Q., Guo Q.L., You Q.D., Zhao L., and Gu H.Y. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol. Pharm. Bull. 27 (2004) 1769-1774
-
(2004)
Biol. Pharm. Bull.
, vol.27
, pp. 1769-1774
-
-
Wu, Z.Q.1
Guo, Q.L.2
You, Q.D.3
Zhao, L.4
Gu, H.Y.5
-
5
-
-
24744435348
-
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid
-
Kasibhatla S., Jessen K.A., Maliartchouk S., Wang J.Y., English N.M., Drewe J., Qiu L., Archer S.P., Ponce A.E., Sirisoma N., Jiang S., Zhang H.Z., Gehlsen K.R., Cai S.X., Green D.R., and Tseng B. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc. Natl. Acad. Sci. USA 102 (2005) 12095-12100
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12095-12100
-
-
Kasibhatla, S.1
Jessen, K.A.2
Maliartchouk, S.3
Wang, J.Y.4
English, N.M.5
Drewe, J.6
Qiu, L.7
Archer, S.P.8
Ponce, A.E.9
Sirisoma, N.10
Jiang, S.11
Zhang, H.Z.12
Gehlsen, K.R.13
Cai, S.X.14
Green, D.R.15
Tseng, B.16
-
6
-
-
34047133853
-
Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells
-
Yu J., Guo Q.L., You Q.D., Zhao L., Gu H.Y., Yang Y., Zhang H.W., Tan Z., and Wang X. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis 28 (2007) 632-638
-
(2007)
Carcinogenesis
, vol.28
, pp. 632-638
-
-
Yu, J.1
Guo, Q.L.2
You, Q.D.3
Zhao, L.4
Gu, H.Y.5
Yang, Y.6
Zhang, H.W.7
Tan, Z.8
Wang, X.9
-
7
-
-
34548679604
-
Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes
-
Yang Y., Yang L., You Q.D., Nie F.F., Gu H.Y., Zhao L., Wang X.T., and Guo Q.L. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Lett. 256 (2007) 259-266
-
(2007)
Cancer Lett.
, vol.256
, pp. 259-266
-
-
Yang, Y.1
Yang, L.2
You, Q.D.3
Nie, F.F.4
Gu, H.Y.5
Zhao, L.6
Wang, X.T.7
Guo, Q.L.8
-
8
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L., Coviello G.M., Wright W.E., Weinrich S.L., and Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 266 (1994) 2011-2015
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
9
-
-
0037114491
-
Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis
-
Liu W.J., Jiang J.F., Xiao D., and Ding J. Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Biochem. Pharmacol. 64 (2002) 1677-1687
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1677-1687
-
-
Liu, W.J.1
Jiang, J.F.2
Xiao, D.3
Ding, J.4
-
10
-
-
0033609046
-
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
-
Liu K., Schoonmaker M.M., Levine B.L., June C.H., Hodes R.J., and Weng N.P. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 5147-5152
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 5147-5152
-
-
Liu, K.1
Schoonmaker, M.M.2
Levine, B.L.3
June, C.H.4
Hodes, R.J.5
Weng, N.P.6
-
11
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., Taylor R.D., Carlos R., Andrews W.H., Wright W.E., Shay J.W., Harley C.B., and Morin G.B. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17 (1997) 498-502
-
(1997)
Nat. Genet.
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
12
-
-
0033571329
-
Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors
-
Wu A., Ichihashi M., and Ueda M. Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors. Cancer 86 (1999) 2038-2044
-
(1999)
Cancer
, vol.86
, pp. 2038-2044
-
-
Wu, A.1
Ichihashi, M.2
Ueda, M.3
-
13
-
-
0037223887
-
Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter
-
Renaud S., Bosman F.T., and Benhattar J. Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. Biochem. Biophys. Res. Commun. 300 (2003) 47-54
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, pp. 47-54
-
-
Renaud, S.1
Bosman, F.T.2
Benhattar, J.3
-
14
-
-
0035871710
-
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
-
Liu K., Hodes R.J., and Weng N. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166 (2001) 4826-4830
-
(2001)
J. Immunol.
, vol.166
, pp. 4826-4830
-
-
Liu, K.1
Hodes, R.J.2
Weng, N.3
-
15
-
-
33745698235
-
Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells
-
Yu J., Guo Q.L., You Q.D., Lin S.S., Li Z., Gu H.Y., Zhang H.W., Tan Z., and Wang X. Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. Cancer Chemother. Pharmacol. 58 (2006) 434-443
-
(2006)
Cancer Chemother. Pharmacol.
, vol.58
, pp. 434-443
-
-
Yu, J.1
Guo, Q.L.2
You, Q.D.3
Lin, S.S.4
Li, Z.5
Gu, H.Y.6
Zhang, H.W.7
Tan, Z.8
Wang, X.9
-
16
-
-
31844434032
-
Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells
-
Guo Q.L., Lin S.S., You Q.D., Gu H.Y., Yu J., Zhao L., Qi Q., Liang F., Tan Z., and Wang X. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci. 78 (2006) 1238-1245
-
(2006)
Life Sci.
, vol.78
, pp. 1238-1245
-
-
Guo, Q.L.1
Lin, S.S.2
You, Q.D.3
Gu, H.Y.4
Yu, J.5
Zhao, L.6
Qi, Q.7
Liang, F.8
Tan, Z.9
Wang, X.10
-
17
-
-
5444259727
-
Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells
-
Wang Q., Bai Z.L., Xuan L., Hou L., and Zhang B. Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells. Chin. Med. Sci. J. 19 (2004) 157-163
-
(2004)
Chin. Med. Sci. J.
, vol.19
, pp. 157-163
-
-
Wang, Q.1
Bai, Z.L.2
Xuan, L.3
Hou, L.4
Zhang, B.5
-
18
-
-
0032911694
-
Direct activation of TERT transcription by c-MYC
-
Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., and Dalla-Favera R. Direct activation of TERT transcription by c-MYC. Nat. Genet. 21 (1999) 220-224
-
(1999)
Nat. Genet.
, vol.21
, pp. 220-224
-
-
Wu, K.J.1
Grandori, C.2
Amacker, M.3
Simon-Vermot, N.4
Polack, A.5
Lingner, J.6
Dalla-Favera, R.7
-
19
-
-
33644512054
-
Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells
-
Jagadeesh S., Kyo S., and Banerjee P.P. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res. 66 (2006) 2107-2115
-
(2006)
Cancer Res.
, vol.66
, pp. 2107-2115
-
-
Jagadeesh, S.1
Kyo, S.2
Banerjee, P.P.3
-
20
-
-
3042672437
-
Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines
-
Kimura A., Ohmichi M., Kawagoe J., Kyo S., Mabuchi S., Takahashi T., Ohshima C., Arimoto-Ishida E., Nishio Y., Inoue M., Kurachi H., Tasaka K., and Murata Y. Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines. Oncogene 23 (2004) 4505-4515
-
(2004)
Oncogene
, vol.23
, pp. 4505-4515
-
-
Kimura, A.1
Ohmichi, M.2
Kawagoe, J.3
Kyo, S.4
Mabuchi, S.5
Takahashi, T.6
Ohshima, C.7
Arimoto-Ishida, E.8
Nishio, Y.9
Inoue, M.10
Kurachi, H.11
Tasaka, K.12
Murata, Y.13
-
21
-
-
1142277821
-
Akt2 expression correlates with prognosis of human hepatocellular carcinoma
-
Xu X., Sakon M., Nagano H., Hiraoka N., Yamamoto H., Hayashi N., Dono K., Nakamori S., Umeshita K., Ito Y., Matsuura N., and Monden M. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol. Rep. 11 (2004) 25-32
-
(2004)
Oncol. Rep.
, vol.11
, pp. 25-32
-
-
Xu, X.1
Sakon, M.2
Nagano, H.3
Hiraoka, N.4
Yamamoto, H.5
Hayashi, N.6
Dono, K.7
Nakamori, S.8
Umeshita, K.9
Ito, Y.10
Matsuura, N.11
Monden, M.12
-
22
-
-
0036195196
-
AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
-
Roy H.K., Olusola B.F., Clemens D.L., Karolski W.J., Ratashak A., Lynch H.T., and Smyrk T.C. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23 (2002) 201-205
-
(2002)
Carcinogenesis
, vol.23
, pp. 201-205
-
-
Roy, H.K.1
Olusola, B.F.2
Clemens, D.L.3
Karolski, W.J.4
Ratashak, A.5
Lynch, H.T.6
Smyrk, T.C.7
-
23
-
-
11144354317
-
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
-
Yamamoto S., Tomita Y., Hoshida Y., Morooka T., Nagano H., Dono K., Umeshita K., Sakon M., Ishikawa O., Ohigashi H., Nakamori S., Monden M., and Aozasa K. Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin. Cancer Res. 10 (2004) 2846-2850
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2846-2850
-
-
Yamamoto, S.1
Tomita, Y.2
Hoshida, Y.3
Morooka, T.4
Nagano, H.5
Dono, K.6
Umeshita, K.7
Sakon, M.8
Ishikawa, O.9
Ohigashi, H.10
Nakamori, S.11
Monden, M.12
Aozasa, K.13
-
24
-
-
19544385752
-
Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention
-
Ang K.L., Shi D.L., Keong W.W., and Epstein R.J. Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention. Cancer Lett. 225 (2005) 53-59
-
(2005)
Cancer Lett.
, vol.225
, pp. 53-59
-
-
Ang, K.L.1
Shi, D.L.2
Keong, W.W.3
Epstein, R.J.4
-
25
-
-
0033532056
-
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
-
Kang S.S., Kwon T., Kwon D.Y., and Do S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274 (1999) 13085-13090
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13085-13090
-
-
Kang, S.S.1
Kwon, T.2
Kwon, D.Y.3
Do, S.I.4
-
26
-
-
38049112379
-
Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma Cells
-
Bu X., Jia F., Wang W., Guo X., Wu M., and Wei L. Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma Cells. BMC Cancer 7 (2007) 208
-
(2007)
BMC Cancer
, vol.7
, pp. 208
-
-
Bu, X.1
Jia, F.2
Wang, W.3
Guo, X.4
Wu, M.5
Wei, L.6
-
27
-
-
18444377359
-
Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway
-
Maida Y., Kyo S., Kanaya T., Wang Z., Yatabe N., Tanaka M., Nakamura M., Ohmichi M., Gotoh N., Murakami S., and Inoue M. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene 21 (2002) 4071-4079
-
(2002)
Oncogene
, vol.21
, pp. 4071-4079
-
-
Maida, Y.1
Kyo, S.2
Kanaya, T.3
Wang, Z.4
Yatabe, N.5
Tanaka, M.6
Nakamura, M.7
Ohmichi, M.8
Gotoh, N.9
Murakami, S.10
Inoue, M.11
-
28
-
-
0037207872
-
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
-
Akiyama M., Hideshima T., Hayashi T., Tai Y.T., Mitsiades C.S., Mitsiades N., Chauhan D., Richardson P., Munshi N.C., and Anderson K.C. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 63 (2003) 18-21
-
(2003)
Cancer Res.
, vol.63
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
Tai, Y.T.4
Mitsiades, C.S.5
Mitsiades, N.6
Chauhan, D.7
Richardson, P.8
Munshi, N.C.9
Anderson, K.C.10
-
29
-
-
17844380300
-
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
-
Kawauchi K., Ihjima K., and Yamada O. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. J. Immunol. 174 (2005) 5261-5269
-
(2005)
J. Immunol.
, vol.174
, pp. 5261-5269
-
-
Kawauchi, K.1
Ihjima, K.2
Yamada, O.3
-
30
-
-
0035975535
-
Protein kinase C modulates telomerase activity in human cervical cancer cells
-
Kim Y.W., Hur S.Y., Kim T.E., Lee J.M., Namkoong S.E., Ki I.K., and Kim J.W. Protein kinase C modulates telomerase activity in human cervical cancer cells. Exp. Mol. Med. 33 (2001) 156-163
-
(2001)
Exp. Mol. Med.
, vol.33
, pp. 156-163
-
-
Kim, Y.W.1
Hur, S.Y.2
Kim, T.E.3
Lee, J.M.4
Namkoong, S.E.5
Ki, I.K.6
Kim, J.W.7
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