Gambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing pdgf receptor β tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells

Journal of Atherosclerosis and Thrombosis

Volumn 17, Issue 9, 2010, Pages 901-913

  Liu, Yong ^a   Li, Wen ^a   Ye, Caisheng ^a   Lin, Ying ^a   Cheang, Tuck Yun ^a   Wang, Mian ^a   Zhang, Hui ^a   Wang, Sanming ^a   Zhang, Longjuan ^a   Wang, ShenMing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Gambogic acid; Migration; Platelet derived growth factor receptor (PDGFR ); Proliferation; Vascular smooth muscle cell

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; DNA; EPIDERMAL GROWTH FACTOR; GAMBOGIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THYMIDINE; TYROSINE;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; CELL COUNT; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; FLOW CYTOMETRY; INTRACELLULAR SIGNALING; MIGRATION INHIBITION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

EID: 77958573005     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.3491     Document Type: Article

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