Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways

Acta Pharmacologica Sinica

Volumn 33, Issue 4, 2012, Pages 531-541

  Lü, Lei ^a   Tang, Dong ^a   Wang, Liang ^a   Huang, Lu Qi ^b   Jiang, Guo Song ^a   Xiao, Xing Yuan ^a   Zeng, Fu Qing ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Jingzhou Central People's Hospital   (China)

Author keywords

gambogic acid; human prostate cancer; NF B signaling pathway; PI3K Akt signaling pathway; Snail; tumor invasion; tumor metastasis; tumor necrosis factor (TNF )

Indexed keywords

FIBRONECTIN; GAMBOGIC ACID; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SNAIL; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN;

ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL INVASION; CELL MIGRATION; CELL NUCLEUS; CELL STIMULATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROSTATE CANCER; PROTEIN BINDING; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL MOVEMENT; GARCINIA; HUMANS; MALE; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; XANTHONES;

EID: 84859610927     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.180     Document Type: Article

References (48)

1. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 2003; 10: 45-65. (Pubitemid 36511832)
2. Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin 2008; 29: 1275-88.
3. Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer 2010; 102: 639-44.
4. Sandra F, Matsuki NA, Takeuchi H, Ikebe T, Kanematsu T, Ohishi M, et al. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cell Signal 2002; 14: 771-8. (Pubitemid 34597184)
5. Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, et al. Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol 2005; 175: 1197-205. (Pubitemid 41095008)
6. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP. Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 2009; 15: 416-28.
7. Choi KW, Park HJ, Jung DH, Kim TW, Park YM, Kim BO, et al. Inhibition of TNF-alpha-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-kappaB signaling pathways. Vascul Pharmacol 2010; 53: 273-80.
8. Liesenklas W, Auterhoff H. The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin. Arch Pharm Ber Dtsch Pharm Ges 1966; 299: 797-8.
9. Zhao L, Guo QL, You QD, Wu ZQ, Gu HY. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull 2004; 27: 998-1003. (Pubitemid 41701748)
10. Yu J, Guo QL, You QD, Zhao L, Gu HY, Yang Y, et al. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis 2007; 28: 632-8. (Pubitemid 46523358)
11. Rong JJ, Hu R, Qi Q, Gu HY, Zhao Q, Wang J, et al. Gambogic acid down-regulates MDM2 oncogene and induces p21 (Waf1/CIP1) expression independent of p53. Cancer Lett 2009; 284: 102-12.
12. He D, Xu Q, Yan M, Zhang P, Zhou X, Zhang Z, et al. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC Cancer 2009; 9: 343.
13. Guo QL, Lin SS, You QD, Gu HY, Yu J, Zhao L, et al. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sci 2006; 78: 1238-45. (Pubitemid 43179978)
14. Lee YC, Lin HH, Hsu CH, Wang CJ, Chiang TA, Chen JH. Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. Eur J Pharmacol 2010; 632: 23-32.
15. Jin L, Hu X, Feng L. NT3 inhibits FGF2-induced neural progenitor cell proliferation via the PI3K/GSK3 pathway. J Neurochem 2005; 93: 1251-61. (Pubitemid 40776578)
16. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-7. (Pubitemid 34579158)
17. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109: 81-96.
18. Hemavathy K, Ashraf SI, Ip YT. Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Gene 2000; 257: 1-12.
19. Barbera MJ, Puig I, Dominguez D, Julien-Grille S, Guaita-Esteruelas S, Peiro S, et al. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 2004; 23: 7345-54. (Pubitemid 39382137)
20. Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 2009; 15: 195-206.
21. Haraguchi M, Okubo T, Miyashita Y, Miyamoto Y, Hayashi M, Crotti TN, et al. Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. J Biol Chem 2008; 283: 23514-23.
22. Blechschmidt K, Sassen S, Schmalfeldt B, Schuster T, Hofler H, Becker KF. The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. Br J Cancer 2008; 98: 489-95. (Pubitemid 351161237)
23. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000; 50: 7-33.
24. Bostwick DG, Burke HB, Djakiew D, Euling S, Ho SM, Landolph J, et al. Human prostate cancer risk factors. Cancer 2004; 101: 2371-490. (Pubitemid 39505434)
25. Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, et al. Multiple cellular mechanisms to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst 2008; 100: 1022-36. (Pubitemid 352019801)
26. Sugar LM. Inflammation and prostate cancer. Can J Urol 2006; 13: 46-7.
27. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NFkappaB pathway in the treatment of inflammation and cancer. J Clin Invest 2001; 107: 135-42. (Pubitemid 32096826)
28. Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle 2009; 8: 3267-73.
29. Kim SJ, Kelly WK, Fu A, Haines K, Hoffman A, Zheng T, et al. Genomewide methylation analysis identifies involvement of TNF-alpha mediated cancer pathways in prostate cancer. Cancer Lett 2011; 302: 47-53.
30. Danforth KN, Rodriguez C, Hayes RB, Sakoda LC, Huang WY, Yu K, et al. TNF polymorphisms and prostate cancer risk. Prostate 2008; 68: 400-7. (Pubitemid 351342645)
31. Qin Z, Kruger-Krasagakes S, Kunzendorf U, Hock H, Diamantstein T, Blankenstein T. Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis. J Exp Med 1993; 178: 355-60. (Pubitemid 23173272)
32. Orosz P, Echtenacher B, Falk W, Ruschoff J, Weber D, Mannel DN. Enhancement of experimental metastasis by tumor necrosis factor. J Exp Med 1993; 177: 1391-8. (Pubitemid 23117129)
33. Bates RC, Mercurio AM. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 2003; 14: 1790-800. (Pubitemid 36583533)
34. Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 2007; 26: 711-24. (Pubitemid 46204250)
35. Balkwill F. Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 2002; 13: 135-41. (Pubitemid 34229388)
36. Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappa B signaling pathway. Blood 2007; 110: 3517-25. (Pubitemid 350159615)
37. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501. (Pubitemid 37328931)
38. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NFkappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999; 401: 82-5.
39. Prawettongsopon C, Asawakarn S, Suthiphongchai T. Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002. Oncol Res 2009; 17: 301-9.
40. Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, et al. Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 2007; 26: 7445-56. (Pubitemid 350158710)
41. Ougolkov AV, Billadeau DD. Targeting GSK-3: a promising approach for cancer therapy? Future Oncol 2006; 2: 91-100.
42. Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116 : 499-511. (Pubitemid 36231290)
43. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002; 3: 155-66.
44. Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y, et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 2004; 90: 1265-73. (Pubitemid 38496823)
45. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161: 1881-91. (Pubitemid 35265545)
46. Martin TA, Goyal A, Watkins G, Jiang WG. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol 2005; 12: 488-96. (Pubitemid 40884264)
47. Yin T, Wang C, Liu T, Zhao G, Zha Y, Yang M. Expression of snail in pancreatic cancer promotes metastasis and chemoresistance. J Surg Res 2007; 141: 196-203. (Pubitemid 47049639)
48. Cho HJ, Baek KE, Saika S, Jeong MJ, Yoo J. Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway. Biochem Biophys Res Commun 2007; 353: 337-43. (Pubitemid 46014570)