Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 32, Issue 2, 2007, Pages 63-68

  Hao, Kun ^a   Liu, Xiao Quan ^a   Wang, Guang Ji ^a   Zhao, Xiao Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Excretion; Gambogic acid (GA); Pharmacokinetics; Tissue distribution

Indexed keywords

GAMBOGIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; FECES ANALYSIS; FEMALE; MALE; NONHUMAN; RAT;

EID: 34547609631     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190993     Document Type: Article

References (9)

1. Lin L.J., Lin L.Z., Pezzuto J.M., Cordell G.A. (1993): Isogambogic acid and isomorellinol from Garcinia hanburyi. Magn. Reson. Chem., 31, 340-347.
2. Based on a lecture. (1982): "The Cooperation of Garabogia Anticancer Investigation", presented at J. Jiangxi Med. Coll., 3, 1-5.
3. Chen B.R. (1980): The investigation of Gambogia anticancer components. J. Jiangxi Med. Coll., 2, 1-7.
4. Lei Q.M., Liu J.M., Gong D.E. (1985): Experimental study on anticancer activity of gamboges. Chin. J. Tumor., 7, 282-285.
5. Dong C., Jin T.Y., Lv F.D. (1988): In vitro experimental investigation for anticancer effect of gamboges. Chin. Bull. Pharm., 23, 89-90.
6. Sun Z., Jiang X.Y., Chen W.Y. (1983): Some toxicity for injection of gamboges. J. Jiangxi Med. Coll., 3, 5-7.
7. Kong L.D., Ye D.J., Wu H. (1995): General surveys for modern study of gamboges. Chin. J. Trad. Med., 20, 89-91.
8. Wu Z.Q., Guo Q.L., You Q.D., Zhao L. (2003): Growth inhibitory effect of GGAs on experimental tumors in mice and Huan tumor cells cultured in vitro. Chin. J. Nat. Med., 1, 99-102.
9. Guo Q.L., You Q.D., Wu Z.Q., Yuan S.T., Zhao L. (2004): General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. Acta Pharmacol. Sin., 25, 769-774.