Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-nuclear magnetic resonance

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 860, Issue 2, 2007, Pages 218-226

  Feng, Feng ^a   Liu, Wenyuan ^a   Wang, Yinghong ^b   Guo, Qinglong ^a   You, Qidong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

10 Hydroxygambogic acid; 9,10 Epoxygambogic acid; Gambogic acid; Metabolites; Structural determination

Indexed keywords

EPOXYGAMBOGIC ACID; GAMBOGIC ACID; HYDROXYGAMBOGIC ACID; RAT BILE; STRUCTURAL DETERMINATION;

ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; TUMORS;

METABOLITES;

10 HYDROXYGAMBOGIC ACID; 10 HYDROXYGAMBOGIC ACID 30 2 GLUCURONIDE; 9,10 EPOXYGAMBOGIC ACID; 9,10 EPOXYGAMBOGIC ACID 30 2 GLUCURONIDE; GAMBOGIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; IN VIVO STUDY; ION TRAP MASS SPECTROMETRY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; XANTHONES;

RATTUS;

EID: 36549089934     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.10.037     Document Type: Article

References (13)

1. Chen B.R. Acta Acad. Med. Jiangxi 2 (1980) 1
2. Guo Q.L., You Q.D., Wu Z.Q., Yuan S.T., and Zhao L. Acta Pharmacol. Sin. 25 (2004) 769
3. Wu Z.Q., Guo Q.L., You Q.D., Zhao L., and Gu H.Y. Biol. Pharm. Bull. 27 (2004) 1769
4. Zhao L., Guo Q.L., You Q.D., Wu Z.Q., and Gu H.Y. Biol. Pharm. Bull. 27 (2004) 998
5. Kasibnatla S., Jessen K.A., Maliartchouk S., Wang J.Y., English N.M., and Drewe J. Cell Biol. 102 (2005) 12095
6. Hao K., Liu X.Q., and Wang G.J. J. Chin. Pharm. Univ. 36 4 (2005) 338
7. Liu Y.T., Hao K., Liu X.Q., and Wang G.J. Acta Pharmacol. Sin. 27 (2006) 1253
8. Silverstein R.M., Webster F.X., and Kiemle D.J. Spectrometric Identification of Organic Compounds. 7th ed. (2005), John Wiley & Sons Publishing, Hoboken
9. S.X. Cai, H.Z. Zhang, Y. Wang, B. Tseng, K. Shailaja, D. John A, Invent Patent WO2000US02332 20000201.
10. Feng F., Liu W.Y., Chen Y.S., Guo Q.L., and You Q.D. J. Asian Nat. Prod. Res. 9 8 (2007) 735
11. Asano J., Chiba K., Tada M., and Yoshi T. Phytochemistry 41 3 (1996) 815
12. Corcoran O., and Spraul M. Drug Discov. Today 8 14 (2003) 624
13. Pukalskas A., van Beek T.A., and de Waard P. J. Chromatogr. A 1074 (2005) 81