Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

Toxicology

Volumn 260, Issue 1-3, 2009, Pages 60-67

  Nie, Feifei ^a   Zhang, Xiaonan ^b   Qi, Qi ^a   Yang, Lan ^a,c   Yang, Yong ^a   Liu, Wei ^a   Lu, Na ^a   Wu, Zhaoqiu ^d   You, Qidong ^a   Guo, Qinglong ^a  

^a Jiangsu Key Laboratory of Carcinogenesis and Intervention   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c Hangzhou Minsheng Pharmaceutical Group Co Ltd   (China)

^d Purdue University   (United States)

Author keywords

Apoptosis; Gambgic acid; Mitochondria; MMP; ROS

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 9; CYTOCHROME C; GAMBOGIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; RESIN; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG ACCUMULATION; DRUG STRUCTURE; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MITOCHONDRIA, LIVER; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; XANTHONES;

GARCINIA HANBURYI;

EID: 67349089550     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.03.010     Document Type: Article

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