Studies on chemical modification and biology of a natural product, gambogic acid (III): Determination of the essential pharmacophore for biological activity

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1280-1290

  Wang, Xiaojian ^a   Lu, Na ^a   Yang, Qian ^a   Gong, Dandan ^a   Lin, Changjun ^a   Zhang, Shenglie ^a   Xi, Meiyang ^a   Gao, Yuan ^a   Wei, Libing ^a   Guo, Qinglong ^a   You, Qidong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

4 oxa tricyclo 4.3.1.03,7 dec 2 one; Anti tumor effects; Gambogic acid; HepG2 cell SAR studies

Indexed keywords

1 (METHOXYMETHOXY) 5,6 BIS(2 METHYLBUT 3 YN 2 YLOXY) 9H XANTHEN 9 ONE; 1,5,6 TRIHYDROXY 9H XANTHEN 9 ONE; 1,5,6 TRIMETHOXY 9H XANTHEN 9 ONE; 10 (METHOXYMETHOXY) 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 10 HYDROXYL 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 2 (METHOXYMETHOXY) 5,6 BIS(2 METHYLBUT 3 YN 2 YLOXY) 9H XANTHEN 9 ONE; 2,5,6 TRIHYDROXY 9H XANTHEN 9 ONE; 2,5,6 TRIMETHOXY 9H XANTHEN 9 ONE; 3,4 BIS(2 METHYLBUT 3 YN 2 YLOXY) 9H XANTHEN 9 ONE; 3,4 DIHYDROXY 5 (METHOXYMETHOXY) 9H XANTHEN 9 ONE; 3,4,5 TRIHYDROXY 9H XANTHEN 9 ONE; 3,4,5 TRIMETHOXY 9H XANTHEN 9 ONE; 3,4,6 TRIHYDROXY 9H XANTHEN 9 ONE; 3,4,6 TRIMETHOXY 9H XANTHEN 9 ONE; 5 (METHOXYMETHOXY) 3,4 BIS(2 METHYLBUT 3 YN 2 YLOXY) 9H XANTHEN 9 ONE; 5,6 DIHYDROXY 1 (METHOXYMETHOXY) 9H XANTHEN 9 ONE; 5,6 DIHYDROXY 2 (METHOXYMETHOXY) 9H XANTHEN 9 ONE; 5,6 DIHYDROXY 3 (METHOXYMETHOXY) 9H XANTHEN 9 ONE; 6 (METHOXYMETHOXY) 3,4 BIS(2 METHYLBUT 3 YN 2 YLOXY) 9H XANTHEN 9 ONE; 7 (METHOXYMETHOXY) 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 7 HYDROXYL 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 8 (METHOXYMETHOXY) 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 8 HYDROXYL 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 9 (METHOXYMETHOXY) 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; 9 HYDROXYL 2,2 DIPHENYL 6H[1,3]DIOXOLO[4,5 C]XANTHEN 6 ONE; ANTINEOPLASTIC AGENT; CAGED XANTHONE; GAMBOGIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG SYNTHESIS; IN VITRO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL PRODUCTS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79952283088     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.051     Document Type: Article

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