메뉴 건너뛰기




Volumn 22, Issue 10, 2013, Pages 2083-2096

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

AF 6 PROTEIN; PARKIN; PROTEASOME; PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

EID: 84877014607     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt058     Document Type: Article
Times cited : (25)

References (59)
  • 2
    • 77957905690 scopus 로고    scopus 로고
    • Genetic analysis of pathways to Parkinson disease
    • Hardy, J. (2010) Genetic analysis of pathways to Parkinson disease. Neuron, 68, 201-206.
    • (2010) Neuron , vol.68 , pp. 201-206
    • Hardy, J.1
  • 4
    • 77953424577 scopus 로고    scopus 로고
    • The role of parkin in familial and sporadic Parkinson's disease
    • Dawson, T.M. and Dawson, V.L. (2010) The role of parkin in familial and sporadic Parkinson's disease. Mov. Disord., 25(Suppl 1), S32-S39.
    • (2010) Mov. Disord. , vol.25 , Issue.SUPPL. 1
    • Dawson, T.M.1    Dawson, V.L.2
  • 9
    • 0034700158 scopus 로고    scopus 로고
    • Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    • Zhang, Y., Gao, J., Chung, K.K., Huang, H., Dawson, V.L. and Dawson, T.M. (2000) Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl Acad. Sci. USA, 97, 13354-13359.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.K.3    Huang, H.4    Dawson, V.L.5    Dawson, T.M.6
  • 11
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
    • Chung, K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C.A., Dawson, V.L. and Dawson, T.M. (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat. Med., 7, 1144-1150.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 12
    • 0037016687 scopus 로고    scopus 로고
    • Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain
    • Fallon, L., Moreau, F., Croft, B.G., Labib, N., Gu, W.J. and Fon, E.A. (2002) Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J. Biol. Chem., 277, 486-491.
    • (2002) J. Biol. Chem. , vol.277 , pp. 486-491
    • Fallon, L.1    Moreau, F.2    Croft, B.G.3    Labib, N.4    Gu, W.J.5    Fon, E.A.6
  • 14
    • 2542534741 scopus 로고    scopus 로고
    • S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
    • Chung, K.K., Thomas, B., Li, X., Pletnikova, O., Troncoso, J.C., Marsh, L., Dawson, V.L. and Dawson, T.M. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science, 304, 1328-1331.
    • (2004) Science , vol.304 , pp. 1328-1331
    • Chung, K.K.1    Thomas, B.2    Li, X.3    Pletnikova, O.4    Troncoso, J.C.5    Marsh, L.6    Dawson, V.L.7    Dawson, T.M.8
  • 16
    • 0032957883 scopus 로고    scopus 로고
    • Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients
    • Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N. et al. (1999) Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients. Ann. Neurol., 45, 668-672.
    • (1999) Ann. Neurol. , vol.45 , pp. 668-672
    • Shimura, H.1    Hattori, N.2    Kubo, S.3    Yoshikawa, M.4    Kitada, T.5    Matsumine, H.6    Asakawa, S.7    Minoshima, S.8    Yamamura, Y.9    Shimizu, N.10
  • 17
  • 19
    • 34250344611 scopus 로고    scopus 로고
    • Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linkerregion modulates Its ubiquitin-ligase activity and aggregation
    • Avraham, E., Rott, R., Liani, E., Szargel, R. and Engelender, S. (2007) Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linkerregion modulates Its ubiquitin-ligase activity and aggregation. J. Biol. Chem., 282, 12842-12850.
    • (2007) J. Biol. Chem. , vol.282 , pp. 12842-12850
    • Avraham, E.1    Rott, R.2    Liani, E.3    Szargel, R.4    Engelender, S.5
  • 21
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    • Petrucelli, L., O'Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J. et al. (2002) Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron, 36, 1007-1019.
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O'Farrell, C.2    Lockhart, P.J.3    Baptista, M.4    Kehoe, K.5    Vink, L.6    Choi, P.7    Wolozin, B.8    Farrer, M.9    Hardy, J.10
  • 26
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441, 1162-1166.
    • (2006) Nature , vol.441 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 27
    • 33745602748 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    • Park, J., Lee, S.B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.M. et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature, 441, 1157-1161.
    • (2006) Nature , vol.441 , pp. 1157-1161
    • Park, J.1    Lee, S.B.2    Lee, S.3    Kim, Y.4    Song, S.5    Kim, S.6    Bae, E.7    Kim, J.8    Shong, M.9    Kim, J.M.10
  • 28
    • 33746080412 scopus 로고    scopus 로고
    • Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    • Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.W., Yang, L., Beal, M.F., Vogel, H. and Lu, B. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl Acad. Sci. USA, 103, 10793-10798.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10793-10798
    • Yang, Y.1    Gehrke, S.2    Imai, Y.3    Huang, Z.4    Ouyang, Y.5    Wang, J.W.6    Yang, L.7    Beal, M.F.8    Vogel, H.9    Lu, B.10
  • 29
    • 77951181836 scopus 로고    scopus 로고
    • PINK1 stabilized by mitochondrial depolarization recruits parkin to damaged mitochondria and activates latent parkin for mitophagy
    • Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C.A., Sou, Y.S., Saiki, S., Kawajiri, S., Sato, F. et al. (2010) PINK1 stabilized by mitochondrial depolarization recruits parkin to damaged mitochondria and activates latent parkin for mitophagy. J. Cell Biol., 189, 211-221.
    • (2010) J. Cell Biol. , vol.189 , pp. 211-221
    • Matsuda, N.1    Sato, S.2    Shiba, K.3    Okatsu, K.4    Saisho, K.5    Gautier, C.A.6    Sou, Y.S.7    Saiki, S.8    Kawajiri, S.9    Sato, F.10
  • 30
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D., Tanaka, A., Suen, D.F. and Youle, R.J. (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol., 183, 795-803.
    • (2008) J. Cell Biol. , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 33
    • 27844605053 scopus 로고    scopus 로고
    • Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6
    • Xie, Z., Huganir, R.L. and Penzes, P. (2005) Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron, 48, 605-618.
    • (2005) Neuron , vol.48 , pp. 605-618
    • Xie, Z.1    Huganir, R.L.2    Penzes, P.3
  • 36
    • 0344875488 scopus 로고    scopus 로고
    • Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones
    • Winklhofer, K.F., Henn, I.H., Kay-Jackson, P.C., Heller, U. and Tatzelt, J. (2003) Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J. Biol. Chem., 278, 47199-47208.
    • (2003) J. Biol. Chem. , vol.278 , pp. 47199-47208
    • Winklhofer, K.F.1    Henn, I.H.2    Kay-Jackson, P.C.3    Heller, U.4    Tatzelt, J.5
  • 37
    • 0037033074 scopus 로고    scopus 로고
    • Parkin accumulation in aggresomes due to proteasome impairment
    • Junn, E., Lee, S.S., Suhr, U.T. and Mouradian, M.M. (2002) Parkin accumulation in aggresomes due to proteasome impairment. J. Biol. Chem., 277, 47870-47877.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47870-47877
    • Junn, E.1    Lee, S.S.2    Suhr, U.T.3    Mouradian, M.M.4
  • 38
    • 0035377241 scopus 로고    scopus 로고
    • Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme
    • Ardley, H.C., Tan, N.G., Rose, S.A., Markham, A.F. and Robinson, P.A. (2001) Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J. Biol. Chem., 276, 19640-19647.
    • (2001) Ubch7. J. Biol. Chem. , vol.276 , pp. 19640-19647
    • Ardley, H.C.1    Tan, N.G.2    Rose, S.A.3    Markham, A.F.4    Robinson, P.A.5
  • 39
    • 78649300971 scopus 로고    scopus 로고
    • p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
    • Narendra, D., Kane, L.A., Hauser, D.N., Fearnley, I.M. and Youle, R.J. (2010) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy, 6, 1090-1106.
    • (2010) Autophagy , vol.6 , pp. 1090-1106
    • Narendra, D.1    Kane, L.A.2    Hauser, D.N.3    Fearnley, I.M.4    Youle, R.J.5
  • 41
    • 14444271574 scopus 로고    scopus 로고
    • Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction
    • Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto, T. et al. (1997) Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol., 139, 517-528.
    • (1997) J. Cell Biol. , vol.139 , pp. 517-528
    • Mandai, K.1    Nakanishi, H.2    Satoh, A.3    Obaishi, H.4    Wada, M.5    Nishioka, H.6    Itoh, M.7    Mizoguchi, A.8    Aoki, T.9    Fujimoto, T.10
  • 42
    • 0030724368 scopus 로고    scopus 로고
    • The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells
    • Yamamoto, T., Harada, N., Kano, K., Taya, S., Canaani, E., Matsuura, Y., Mizoguchi, A., Ide, C. and Kaibuchi, K. (1997) The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J. Cell Biol., 139, 785-795.
    • (1997) J. Cell Biol. , vol.139 , pp. 785-795
    • Yamamoto, T.1    Harada, N.2    Kano, K.3    Taya, S.4    Canaani, E.5    Matsuura, Y.6    Mizoguchi, A.7    Ide, C.8    Kaibuchi, K.9
  • 44
    • 0034916230 scopus 로고    scopus 로고
    • PDZ domains and the organization of supramolecular complexes
    • Sheng, M. and Sala, C. (2001) PDZ domains and the organization of supramolecular complexes. Annu. Rev. Neurosci., 24, 1-29.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1-29
    • Sheng, M.1    Sala, C.2
  • 45
    • 58049209715 scopus 로고    scopus 로고
    • Pruning and loss of excitatory synapses by the parkin ubiquitin ligase
    • Helton, T.D., Otsuka, T., Lee, M.C., Mu, Y. and Ehlers, M.D. (2008) Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc. Natl. Acad. Sci. USA, 105, 19492-19497.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19492-19497
    • Helton, T.D.1    Otsuka, T.2    Lee, M.C.3    Mu, Y.4    Ehlers, M.D.5
  • 50
    • 79953231682 scopus 로고    scopus 로고
    • Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease
    • Wang, H., Song, P., Du, L., Tian, W., Yue, W., Liu, M., Li, D., Wang, B., Zhu, Y., Cao, C. et al. (2011) Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J. Biol. Chem., 286, 11649-11658.
    • (2011) J. Biol. Chem. , vol.286 , pp. 11649-11658
    • Wang, H.1    Song, P.2    Du, L.3    Tian, W.4    Yue, W.5    Liu, M.6    Li, D.7    Wang, B.8    Zhu, Y.9    Cao, C.10
  • 51
    • 84859962717 scopus 로고    scopus 로고
    • The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax
    • Johnson, B.N., Berger, A.K., Cortese, G.P. and Lavoie, M.J. (2012) The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax. Proc. Natl. Acad. Sci. USA, 109, 6283-6288.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 6283-6288
    • Johnson, B.N.1    Berger, A.K.2    Cortese, G.P.3    Lavoie, M.J.4
  • 53
    • 79959242100 scopus 로고    scopus 로고
    • Mitochondrial contribution to Parkinson's disease pathogenesis
    • Schapira, A.H. and Gegg, M. (2011) Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis., 2011, 159160.
    • (2011) Parkinsons Dis , vol.2011 , pp. 159160
    • Schapira, A.H.1    Gegg, M.2
  • 54
    • 33645833646 scopus 로고    scopus 로고
    • Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients
    • Eyal, A., Szargel, R., Avraham, E., Liani, E., Haskin, J., Rott, R. and Engelender, S. (2006) Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients. Proc. Natl. Acad. Sci. USA, 103, 5917-5922.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 5917-5922
    • Eyal, A.1    Szargel, R.2    Avraham, E.3    Liani, E.4    Haskin, J.5    Rott, R.6    Engelender, S.7
  • 58
    • 11144358336 scopus 로고    scopus 로고
    • Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodiesimply a role in Parkinson's disease
    • Liani, E., Eyal, A., Avraham, E., Shemer, R., Szargel, R., Berg, D., Bornemann, A., Riess, O., Ross, C.A., Rott, R. et al. (2004) Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodiesimply a role in Parkinson's disease. Proc. Natl Acad. Sci. USA, 101, 5500-5505.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 5500-5505
    • Liani, E.1    Eyal, A.2    Avraham, E.3    Shemer, R.4    Szargel, R.5    Berg, D.6    Bornemann, A.7    Riess, O.8    Ross, C.A.9    Rott, R.10
  • 59
    • 0033543748 scopus 로고    scopus 로고
    • Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury
    • Bai, J., Rodriguez, A.M., Melendez, J.A. and Cederbaum, A.I. (1999) Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury. J. Biol. Chem., 274, 26217-26224.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26217-26224
    • Bai, J.1    Rodriguez, A.M.2    Melendez, J.A.3    Cederbaum, A.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.