Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

Neurobiology of Disease

Volumn 20, Issue 2, 2005, Pages 401-411

  Bandopadhyay, Rina ^a   Kingsbury, Ann E ^a,b   Muqit, Miratul M ^c   Harvey, Kirsten ^d   Reid, Andrew R ^a   Kilford, Linda ^b   Engelender, Simone ^e   Schlossmacher, Michael G ^f   Wood, Nicholas W ^b   Latchman, David S ^c,g   Harvey, Robert J ^d   Lees, Andrew J ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Aggresomes; Distribution; Immunoelectron microscopy; Immunohistochemistry; Lewy bodies; MG 132; Parkin; Proteasome inhibitor; Synphilin 1; Yeast two hybrid analysis

Indexed keywords

ALPHA SYNUCLEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; PARKIN; PROTEIN; SYNPHILIN 1; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DISEASE PREDISPOSITION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; LEWY BODY; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

AGED; AGED, 80 AND OVER; BRAIN; CARRIER PROTEINS; CELL LINE, TUMOR; CEREBRAL CORTEX; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; SUBSTANTIA NIGRA; UBIQUITIN-PROTEIN LIGASES;

EID: 24644448584     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.03.021     Document Type: Article

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