A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Roche, Michael ^a   Salimi, Hamid ^a   Duncan, Renee ^a   Wilkinson, Brendan L ^c   Chikere, Kelechi ^d   Moore, Miranda S ^a,g   Webb, Nicholas E ^d   Zappi, Helena ^a,b   Sterjovski, Jasminka ^a   Flynn, Jacqueline K ^a   Ellett, Anne ^a   Gray, Lachlan R ^a   Lee, Benhur ^d   Jubb, Becky ^e   Westby, Mike ^e   Ramsland, Paul A ^a,b   Lewin, Sharon R ^a,f   Payne, Richard J ^c   Churchill, Melissa J ^a   Gorry, Paul R ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^f ALFRED HOSPITAL   (Australia)

^g Fred Hutchinson Cancer Research Center   (United States)

Author keywords

CCR5 ECLs; CCR5 N terminus; Env; Gp120; HIV 1; Maraviroc; Resistance; V3 loop

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; GLYCOPROTEIN GP 120; HISTONE; MARAVIROC; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; TYROSINE; VICRIVIROC;

AMINO TERMINAL SEQUENCE; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG TREATMENT FAILURE; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VIVO STUDY; MATHEMATICAL MODEL; MOLECULAR CLONING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; VIRUS ENTRY; VIRUS INHIBITION; VIRUS NEUTRALIZATION;

ANTI-HIV AGENTS; CYCLOHEXANES; GENETIC VARIATION; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; SEQUENCE ANALYSIS, DNA; TREATMENT FAILURE; TRIAZOLES; VIRUS INTERNALIZATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876992931     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-43     Document Type: Article

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