V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies

PLoS Pathogens

Volumn 3, Issue 8, 2007, Pages 1118-1128

  Laakso, Meg M ^a   Lee, Fang Hua ^a   Haggarty, Beth ^a   Agrawal, Caroline ^a   Nolan, Katrina M ^a   Biscone, Mark ^a   Romano, Josephine ^a   Jordan, Andrea P O ^a   Leslie, George J ^a   Meissner, Eric G ^b,c   Su, Lishan ^b,c   Hoxie, James A ^a   Doms, Robert W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4 METHYL 4 PIPERIDINYL] 2 METHYL 1 [1 [4 (TRIFLUOOROMETHYL)PHENYL]ETHYL]PIPERAZINE; APLAVIROC; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; ENVELOPE PROTEIN; EPITOPE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; NEUTRALIZING ANTIBODY; CHEMOKINE RECEPTOR; HIV ENVELOPE PROTEIN GP120 (305 321); HIV ENVELOPE PROTEIN GP120 (305-321); HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; SERODIAGNOSIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

BASE SEQUENCE; CELL LINE; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV FUSION INHIBITORS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECEPTORS, HIV; VIRUS REPLICATION;

EID: 34548434773     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.0030117     Document Type: Article

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