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Volumn 56, Issue 3, 2011, Pages 222-229

Mapping and characterization of vicriviroc resistance mutations from HIV-1 isolated from treatment-experienced subjects enrolled in a phase II study (VICTOR-E1)

Author keywords

clonal analysis; HIV 1; resistance; tropism; vicriviroc

Indexed keywords

GLYCOPROTEIN GP 160; PLACEBO; VICRIVIROC; VIRUS RNA;

EID: 79951810774     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181ff63ee     Document Type: Article
Times cited : (22)

References (20)
  • 1
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    • DOI 10.1146/annurev.immunol.17.1.657
    • Berger EA, Murphy PM, and Farber JM. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Ann Rev Immunol. 1999;17:657-700. (Pubitemid 29241137)
    • (1999) Annual Review of Immunology , vol.17 , pp. 657-700
    • Berger, E.A.1    Murphy, P.M.2    Farber, J.M.3
  • 5
    • 34047271098 scopus 로고    scopus 로고
    • HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
    • DOI 10.1016/j.virol.2006.11.004, PII S0042682206008245
    • Pugach P, Marozsan AJ, Ketas TJ, et al. HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology. 2007;361:212-228. (Pubitemid 46551222)
    • (2007) Virology , vol.361 , Issue.1 , pp. 212-228
    • Pugach, P.1    Marozsan, A.J.2    Ketas, T.J.3    Landes, E.L.4    Moore, J.P.5    Kuhmann, S.E.6
  • 6
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J Virol. 2007;81:2359-2371.
    • (2007) J Virol , vol.81 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 7
    • 40849085150 scopus 로고    scopus 로고
    • Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120
    • Ogert RA, Wojcik L, Buontempo C, et al. Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120. Virology. 2008;373:387-399.
    • (2008) Virology , vol.373 , pp. 387-399
    • Ogert, R.A.1    Wojcik, L.2    Buontempo, C.3
  • 8
    • 77951884647 scopus 로고    scopus 로고
    • Characterization of emergent HIV resistance in treatment naive subjects enrolled in a vicriviroc phase 2 trial
    • McNicholas P, Wei Y, Whitcomb J, et al. Characterization of emergent HIV resistance in treatment naive subjects enrolled in a vicriviroc phase 2 trial. J Infect Dis. 2010;201:1470-1480.
    • (2010) J Infect Dis , vol.201 , pp. 1470-1480
    • McNicholas, P.1    Wei, Y.2    Whitcomb, J.3
  • 9
    • 75749126915 scopus 로고    scopus 로고
    • Vicriviroc in combination therapy with an optimized regimen for treatment experienced subjects: 48 week results of the VICTOR-E1 phase 2 trial
    • Suleiman J, Zingman BS, Diaz RS, et al. Vicriviroc in combination therapy with an optimized regimen for treatment experienced subjects: 48 week results of the VICTOR-E1 phase 2 trial. J Infect Dis. 2010;201: 590-599.
    • (2010) J Infect Dis , vol.201 , pp. 590-599
    • Suleiman, J.1    Zingman, B.S.2    Diaz, R.S.3
  • 10
    • 49149118151 scopus 로고    scopus 로고
    • In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject
    • Tsibris AMN, Sagar M, Gulick RM, et al. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol. 2008;82:8210-8214.
    • (2008) J Virol , vol.82 , pp. 8210-8214
    • Amn, T.1    Sagar, M.2    Gulick, R.M.3
  • 11
    • 54749134143 scopus 로고    scopus 로고
    • Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection
    • Landovitz RJ, Angel JB, Hoffmann C, et al. Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection. J Infect Dis. 2008;198:1113-1122.
    • (2008) J Infect Dis , vol.198 , pp. 1113-1122
    • Landovitz, R.J.1    Angel, J.B.2    Hoffmann, C.3
  • 16
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol. 2006;80:4909-4920.
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 17
    • 84858159077 scopus 로고    scopus 로고
    • An enhanced-sensitivity TrofileTM HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5: A review of analytical and clinical studies
    • Reeves JD, Coakley E, Petropoulos CJ, et al. An enhanced-sensitivity TrofileTM HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5: a review of analytical and clinical studies. J Viral Entry. 2009;3:94-102.
    • (2009) J Viral Entry , vol.3 , pp. 94-102
    • Reeves, J.D.1    Coakley, E.2    Petropoulos, C.J.3
  • 18
    • 77649188640 scopus 로고    scopus 로고
    • Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5
    • Ogert RA, Hou Y, Ba L, et al. Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5. Virology. 2010;400:145-155.
    • (2010) Virology , vol.400 , pp. 145-155
    • Ogert, R.A.1    Hou, Y.2    Ba, L.3
  • 19
    • 63149107038 scopus 로고    scopus 로고
    • Relationship between HIV coreceptor tropism and disease progression in persons with untreated chronic HIV infection
    • Goetz MB, Leduc R, Kostman JR, et al. Relationship between HIV coreceptor tropism and disease progression in persons with untreated chronic HIV infection. J Acquir Immune Defic Syndr. 2009;50:259-266.
    • (2009) J Acquir Immune Defic Syndr , vol.50 , pp. 259-266
    • Goetz, M.B.1    Leduc, R.2    Kostman, J.R.3
  • 20
    • 65249151382 scopus 로고    scopus 로고
    • Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
    • Cleo G, Anastassopoulou CG, Ketas TJ, et al. Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41. Proc Natl Acad Sci USA. 2009;106:5318-5323.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 5318-5323
    • Cleo, G.1    Anastassopoulou, C.G.2    Ketas, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.