Human Germline Antibody Gene Segments Encode Polyspecific Antibodies

PLoS Computational Biology

Volumn 9, Issue 4, 2013, Pages

  Willis, Jordan R ^a,b   Briney, Bryan S ^c   DeLuca, Samuel L ^a,b   Crowe, James E ^c   Meiler, Jens ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENCODING (SYMBOLS); EPITOPES; GENE ENCODING;

ANTIBODY GENES; ANTIBODY MATURATION; BINDING AFFINITIES; BINDING SPECIFICITIES; COMPUTATIONAL DESIGN; GERMLINE; GERMLINE GENES; IN-SILICO; ROSETTA; STRUCTURAL FLEXIBILITIES;

ANTIBODIES;

ANTIBODY; IMMUNOGLOBULIN; POLYSPECIFIC ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; COMPUTER MODEL; GENE MUTATION; GENE SEQUENCE; GERM LINE; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN VARIABLE HEAVY CHAIN GENE; PROCESS DESIGN; ROSETTA MULTISTAGE DESIGN; SEQUENCE ALIGNMENT; SOMATIC MUTATION;

EID: 84876909725     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003045     Document Type: Article

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