SnugDock: Paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models

PLoS Computational Biology

Volumn 6, Issue 1, 2010, Pages

  Sircar, Aroop ^a   Gray, Jeffrey J ^b  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BINDING ENERGY; CRYSTAL STRUCTURE; FORECASTING; RIGID STRUCTURES; STRUCTURAL OPTIMIZATION;

ANTIBODY ENGINEERING; ANTIBODY-ANTIGEN; BINDING INTERFACE; COMPUTATIONAL TOOLS; CRYSTALLOGRAPHIC STRUCTURE; CRYSTALS STRUCTURES; HIGH-RESOLUTION STRUCTURES; HOMOLOGY MODELING; PARATOPE; STRUCTURAL OPTIMISATIONS;

ANTIBODIES;

ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HEAVY CHAIN; HUMAN; STRUCTURE ANALYSIS; ALGORITHM; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN BINDING; STRUCTURAL HOMOLOGY;

ANTIBODY; ANTIGEN;

ALGORITHMS; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; BINDING SITES, ANTIBODY; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 76749153896     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000644     Document Type: Article

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