Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility

Proteins: Structure, Function and Bioinformatics

Volumn 75, Issue 4, 2009, Pages 846-858

  Babor, Mariana ^a,b   Kortemme, Tanja ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Affinity maturation; Antibody flexibility; Computational design; Computational structural biology; Multi constraint design

Indexed keywords

ANTIBODY; GERMLINE ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BINDING SITE; BIOLOGY; COMPLEMENTARITY DETERMINING REGION; COMPLEMENTARITY DETERMINING REGION H3 LOOP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN-ANTIBODY COMPLEX; BINDING SITES, ANTIBODY; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; IMMUNOGLOBULIN HEAVY CHAINS; MODELS, CHEMICAL; MODELS, MOLECULAR; PLIABILITY; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66149181778     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22293     Document Type: Article

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