Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones

Journal of Immunology

Volumn 180, Issue 5, 2008, Pages 3279-3288

  Tian, Cuixia ^a   Luskin, Grace K ^a   Dischert, Kevin M ^a   Higginbotham, James N ^a   Shepherd, Bryan E ^a   Crowe Jr , James E ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD19 ANTIBODY; CD27 ANTIGEN; IMMUNOGLOBULIN D; PROTEIN VP6; CAPSID PROTEIN; EPITOPE; IMMUNOGLOBULIN HEAVY CHAIN; VIRUS ANTIBODY; VIRUS ANTIGEN; VP6 PROTEIN, ROTAVIRUS;

ADULT; ANTIGEN ANTIBODY REACTION; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; CELL CLONE; CELL COMPARTMENTALIZATION; CELL LEVEL; CELL SPECIFICITY; COMPARATIVE STUDY; GENE STRUCTURE; GENE SWITCHING; HUMAN; HUMAN CELL; HUMAN ROTAVIRUS; IMMUNOPHENOTYPING; MEMORY CELL; PRIORITY JOURNAL; SOMATIC MUTATION; VDJ EXON; CELL CYCLE G0 PHASE; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; ROTAVIRUS; SOMATIC HYPERMUTATION; VIROLOGY;

ADULT; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; B-LYMPHOCYTE SUBSETS; CAPSID PROTEINS; CLONE CELLS; EPITOPES, B-LYMPHOCYTE; G0 PHASE; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MIDDLE AGED; ROTAVIRUS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 49149093819     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.5.3279     Document Type: Article

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