Cigarette smoke extract induces differential expression levels of beta-defensin peptides in human alveolar epithelial cells

Tobacco Induced Diseases

Volumn 11, Issue 1, 2013, Pages

  Pierson, Tony ^a   Learmonth Pierson, Sarah ^a   Pinto, Daniel ^a   Van Hoek, Monique L ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

defensins; Alveolar epithelial cells; Antimicrobial peptide; Cigarette smoke extract; Lung

Indexed keywords

BETA DEFENSIN; CIGARETTE SMOKE; CIGARETTE SMOKE EXTRACT; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOTHESIS; IMMUNOFLOURESCENCE MICROSCOPY; LUNG ALVEOLUS CELL; LUNG PARENCHYMA; MICROSCOPY; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMOKING;

EID: 84876801591     PISSN: None     EISSN: 16179625     Source Type: Journal    
DOI: 10.1186/1617-9625-11-10     Document Type: Article

References (61)

1. Uncovering the effects of smoking: historical perspective. Doll R, Stat Methods Med Res 1998 7 2 87 117 10.1191/096228098668199908 9654637
2. Lung adenocarcinoma: lessons in translation from bench to bedside. Sangodkar J, Mt Sinai J Med 2010 77 6 597 605 10.1002/msj.20226 21105123
3. New insights into the immunology of chronic obstructive pulmonary disease. Brusselle GG, Joos GF, Bracke KR, Lancet 2011 378 9795 1015 1026 10.1016/S0140-6736(11)60988-4 21907865
4. Cigarette smoke inhibits macrophage sensing of Gram-negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress. McMaster SK, Br J Pharmacol 2008 153 3 536 543 10.1038/sj.bjp.0707595 18059323
5. Detection of mutagenic activity in cigarette smoke condensates. Kier LD, Yamasaki E, Ames BN, Proc Natl Acad Sci U S A 1974 71 10 4159 4163 10.1073/pnas.71.10.4159 4610572
6. IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values. Smith CJ, Food Chem Toxicol 2003 41 6 807 817 10.1016/S0278-6915(03)00021-8 12738186
7. Effect of cigarette filters on the chemical composition and in vitro biological activity of cigarette mainstream smoke. Shin HJ, Food Chem Toxicol 2009 47 1 192 197 10.1016/j.fct.2008.10.028 19027817
8. Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models. Nikota JK, Stampfli MR, Pulm Pharmacol Ther 2012 25 4 257 262 10.1016/j.pupt.2012.05.005 22634304
9. Cigarette smoke-induced airway inflammation as sampled by the expired breath condensate. Dwyer TM, Am J Med Sci 2003 326 4 174 178 10.1097/00000441-200310000-00004 14557729
10. Human defensins and LL-37 in mucosal immunity. Doss M, J Leukoc Biol 2010 87 1 79 92 10.1189/jlb.0609382 19808939
11. Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease. Andresen E, PLoS One 2011 6 7 21898 10.1371/journal.pone. 0021898 21818276
12. Enhanced expression of human beta-defensin 2 in peripheral lungs of patients with chronic obstructive pulmonary disease. Liao Z, Peptides 2012 38 2 350 356 10.1016/j.peptides.2012.09.013 23000304
13. Genomic copy number determines functional expression of beta-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Janssens W, Am J Respir Crit Care Med 2010 182 2 163 169 10.1164/rccm.200905-0767OC 20378733
14. Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease. Matsushita I, Biochem Biophys Res Commun 2002 291 1 17 22 10.1006/bbrc.2002.6395 11829455
15. Antimicrobial activity of human beta-defensins and induction by Francisella. Han S, Bishop BM, van Hoek ML, Biochem Biophys Res Commun 2008 371 4 670 674 10.1016/j.bbrc.2008.04.092 18452706
16. Assessment of cell line models of primary human cells by Raman spectral phenotyping. Swain RJ, Biophys J 2010 98 8 1703 1711 10.1016/j.bpj.2009.12.4289 20409492
17. Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity. Hiemstra PS, Biochem Soc Trans 2006 34 Pt 2 276 278 16545093
18. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Schutte BC, Proc Natl Acad Sci U S A 2002 99 4 2129 2133 10.1073/pnas.042692699 11854508
19. Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. Rodriguez-Jimenez FJ, Genomics 2003 81 2 175 183 10.1016/S0888-7543(02)00034-4 12620395
20. Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases. Yamaguchi Y, Ouchi Y, Proc Jpn Acad Ser B Phys Biol Sci 2012 88 4 152 166 10.2183/pjab.88.152 22498979
21. Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Garcia JR, Cell Tissue Res 2001 306 2 257 264 10.1007/s004410100433 11702237
22. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. Garcia JR, FASEB J 2001 15 10 1819 1821 11481241
23. The airway epithelium: soldier in the fight against respiratory viruses. Vareille M, Clin Microbiol Rev 2011 24 1 210 229 10.1128/CMR.00014-10 21233513
24. ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes. Kao CY, Am J Respir Cell Mol Biol 2003 29 1 71 80 10.1165/rcmb.2002-0205OC 12600824
25. The yin and yang of human Beta-defensins in health and disease. Weinberg A, Front Immunol 2012 3 294 23060878
26. Effects of cigarette smoke on the lung and systemic immunity. Domagala-Kulawik J, J Physiol Pharmacol 2008 59 Suppl 6 19 34 19261968
27. Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Chen X, Eur J Immunol 2007 37 2 434 444 10.1002/eji.200636379 17230440
28. Cigarette smoke enhances beta-defensin 2 expression in rat airways via nuclear factor-kappaB activation. Chen L, Eur Respir J 2010 36 3 638 645 10.1183/09031936.00029409 20150208
29. Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. Mahanonda R, J Periodontal Res 2009 44 4 557 564 10.1111/j.1600-0765.2008.01153.x 19438974
30. Whole cigarette smoke increased the expression of TLRs, HBDs, and proinflammory cytokines by human gingival epithelial cells through different signaling pathways. Semlali A, PLoS One 2012 7 12 52614 10.1371/journal.pone. 0052614 23300722
31. Cigarette smoke inhibits airway epithelial cell innate immune responses to bacteria. Kulkarni R, Infect Immun 2010 78 5 2146 2152 10.1128/IAI.01410-09 20194598
32. Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella. Amer LS, Bishop BM, van Hoek ML, Biochem Biophys Res Commun 2010 396 2 246 251 10.1016/j.bbrc.2010.04.073 20399752
33. Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms. Alekseeva L, BMC Microbiol 2009 9 33 10.1186/1471-2180-9-33 19208266
34. Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine. Pierson T, J Proteome Res 2011 10 3 954 967 10.1021/pr1009756 21138299
35. Suppression of pulmonary innate host defence in smokers. Herr C, Thorax 2009 64 2 144 149 10.1136/thx.2008.102681 18852155
36. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. O'Neil DA, J Immunol 1999 163 12 6718 6724 10586069
37. Defence molecules in intestinal innate immunity against bacterial infections. Eckmann L, Curr Opin Gastroenterol 2005 21 2 147 151 10.1097/01.mog.0000153311.97832.8c 15711205
38. Regulation of surfactant secretion in alveolar type II cells. Andreeva AV, Kutuzov MA, Voyno-Yasenetskaya TA, Am J Physiol Lung Cell Mol Physiol 2007 293 2 259 L271 10.1152/ajplung.00112.2007 17496061
39. Alveolar epithelial type II cell: defender of the alveolus revisited. Fehrenbach H, Respir Res 2001 2 1 33 46 10.1186/rr36 11686863
40. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Hsieh SJ, Crit Care Med 2011 39 1 40 45 10.1097/CCM.0b013e3181fa4196 20935560
41. Relationship between biomarkers of cigarette smoke exposure and biomarkers of inflammation, oxidative stress, and platelet activation in adult cigarette smokers. Liu J, Cancer Epidemiol Biomarkers Prev 2011 20 8 1760 1769 10.1158/1055-9965.EPI-10-0987 21708936
42. Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure. Morin A, Regul Toxicol Pharmacol 2011 61 3 Suppl 3 S12 20937342
43. Differential exposure biomarker levels among cigarette smokers and smokeless tobacco consumers in the National Health and Nutrition Examination Survey 1999-2008. Naufal ZS, Biomarkers 2011 16 3 222 235 10.3109/1354750X.2010. 546013 21348778
44. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Sexton K, Biomarkers 2011 16 7 567 576 10.3109/1354750X.2011.608855 21966894
45. Circulating biomarkers of hazard effects from cigarette smoking. Yuchuan H, Toxicol Ind Health 2011 27 6 531 535 10.1177/0748233710393393 21415095
46. Increases in tobacco exposure biomarkers measured in non-smokers exposed to sidestream cigarette smoke under controlled conditions. Bernert JT, Biomarkers 2009 14 2 82 93 10.1080/13547500902774613 19330586
47. Variable expression of human Beta defensins 3 and 9 at the human ocular surface in infectious keratitis. Otri AM, Invest Ophthalmol Vis Sci 2012 53 2 757 761 10.1167/iovs.11-8467 22232436
48. Legionella pneumophila induces human beta defensin-3 in pulmonary cells. Scharf S, Respir Res 2010 11 93 10.1186/1465-9921-11-93 20615218
49. Beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells. Gross CA, BMC Pulm Med 2010 10 30 10.1186/1471-2466-10-30 20470412
50. Enhanced expression of human beta-defensin 2 in peripheral lungs of patients with chronic obstructive pulmonary disease. Liao Z, Peptides 2012 38 350 356 10.1016/j.peptides.2012.09.013 23000304
51. Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients. Pace E, PLoS One 2012 7 3 33601 10.1371/journal.pone.0033601 22438960
52. Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells. Zhang W, Respirology 2011 16 3 508 516 10.1111/j.1440-1843.2010.01920.x 21199162
53. Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs. Shibata Y, Respirology 2008 13 7 1061 1065 18699806
54. Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis. Yamin M, J Allergy Clin Immunol 2008 122 6 1145 1153 e3 10.1016/j.jaci.2008.09.033 18986692
55. Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line. Nakamura S, Med Mol Morphol 2010 43 4 204 210 10.1007/s00795-010-0493-4 21267696
56. Cigarette smoking and inflammation: cellular and molecular mechanisms. Lee J, Taneja V, Vassallo R, J Dent Res 2012 91 2 142 149 10.1177/ 0022034511421200 21876032
57. Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha secretion from macrophages via substance P-mediated nuclear factor-kappaB activation. Xu J, Xu F, Lin Y, Am J Respir Cell Mol Biol 2011 44 3 302 308 10.1165/rcmb.2009-0288OC 20160043
58. Human beta-defensin-2 enhances IFN-gamma and IL-10 production and suppresses IL-17 production in T cells. Kanda N, J Leukoc Biol 2011 89 6 935 944 10.1189/jlb.0111004 21367976
59. Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation. Winter J, Cancer Invest 29 3 196 201
60. Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus. Kreuter A, J Am Acad Dermatol 2011 65 1 125 133 10.1016/j.jaad.2010.12.012 21353331
61. Immunohistochemical analysis of beta-defensin-2 expression in human lung tumors. Shestakova T, Exp Oncol 2010 32 4 273 276 21270758