Genomic copy number determines functional expression of β-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 2, 2010, Pages 163-169

  Janssens, Wim ^a   Nuytten, Hilde ^b   Dupont, Lieven J ^a   Van Eldere, Johan ^b   Vermeire, Severine ^a   Lambrechts, Diether ^b   Nackaerts, Kristiaan ^a   Decramer, Marc ^a   Cassiman, Jean Jacques ^b   Cuppens, Harry ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Chromosome 8p; DEFB4; Genetic polymorphism; hBD2; Pseudomonas aeruginosa

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 4; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; BETA DEFENSIN; DEFB4 PROTEIN, HUMAN; INTERLEUKIN 8;

ADULT; AGED; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL SURVIVAL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; COPY NUMBER VARIATION; DIPLOIDY; EPITHELIUM CELL; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NOSE MUCOSA; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFLAMMATION; RISK ASSESSMENT; UPREGULATION; CASE CONTROL STUDY; CELL CULTURE; CYTOLOGY; GENE DOSAGE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; METABOLISM; MIDDLE AGED; POLYMERASE CHAIN REACTION;

AGED; BETA-DEFENSINS; CASE-CONTROL STUDIES; CELLS, CULTURED; DIPLOIDY; EPITHELIAL CELLS; FEMALE; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NASAL MUCOSA; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; UP-REGULATION;

EID: 77956624830     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200905-0767OC     Document Type: Article

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