Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Pace, Elisabetta ^a   Ferraro, Maria ^a   Minervini, Marta Ida ^b   Vitulo, Patrizio ^c   Pipitone, Loredana ^c   Chiappara, Giuseppina ^a   Siena, Liboria ^a   Montalbano, Angela Marina ^a   Johnson, Malcolm ^d   Gjomarkaj, Mark ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES ISMETT   (Italy)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; BRONCHODILATING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; TOLL LIKE RECEPTOR 4; BETA DEFENSIN; DEFB4A PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ANATOMICAL VARIATION; ARTICLE; BRONCHUS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; MALE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SMOKING; CASE CONTROL STUDY; CELL LINE; DOWN REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY;

BACTERIA (MICROORGANISMS);

AGED; BASE SEQUENCE; BETA-DEFENSINS; BRONCHI; CASE-CONTROL STUDIES; CELL LINE; DOWN-REGULATION; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMOKING; TOLL-LIKE RECEPTOR 4;

EID: 84863418521     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033601     Document Type: Article

References (41)

1. Sullivan SD, Ramsey SD, Lee TA, (2000) The economic burden of COPD. Chest 117: 5S-9S.
2. Murray CJ, Lopez AD, (1997) Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 349: 1498-1504.
3. Sethi S, Maloney J, Grove L, Wrona C, Berenson CS, (2006) Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 173: 991-998.
4. Aderem A, Ulevitch RJ, (2000) Toll-like receptors in the induction of the innate immune response. Nature 406: 782-787.
5. Boodoo S, Spannhake EW, Powell JD, Horton MR, (2006) Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 291: L479-L486.
6. Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP, (2004) Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 31: 358-364.
7. Hamilton LM, Davies DE, Wilson SJ, Kimber I, Dearman RJ, et al. (2001) The bronchial epithelium in asthma-much more than a passive barrier. Monaldi Arch Chest Dis 56: 48-54.
8. Kato A, Schleimer RP, (2007) Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol 19: 711-720.
9. Zhang W, Case S, Bowler RP, Martin RJ, Jiang D, et al. (2011) Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells. Respirology 16: 508-516.
10. Petecchia L, Sabatini F, Varesio L, Camoirano A, Usai C, et al. (2009) Bronchial Airway Epithelial Cell Damage Following Exposure to Cigarette Smoke Includes Disassembly of Tight Junction Components Mediated by the Extracellular Signal-Regulated Kinase 1/2 Pathway. Chest 135: 1502-1512.
11. Pace E, Ferraro M, Siena L, Melis M, Montalbano A, et al. (2008) Cigarette smoke increases TLR4 and modifies LPS mediated responses in airway epithelial cells. Immunology 124: 401-411.
12. Hogg JC, (2004) Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364: 709-721.
13. Saetta M, Di Stefano A, Turato G, Facchini FM, Corbino L, et al. (1998) CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 157: 822-826.
14. Chiappara G, Chanez P, Bruno A, Pace E, Pompeo F, et al. (2007) Variable p-CREB expression depicts different asthma phenotypes. Allergy 62: 787-794.
15. Miotto D, Hollenberg MD, Bunnett NW, Papi A, Braccioni F, et al. (2002) Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers. Thorax 57: 146-151.
16. Kolble K, (2000) The LEICA microdissection system: design and applications. J Mol Med 78: B24-B25.
17. Pace E, Siena L, Ferraro M, Profita M, Mondello P, et al. (2006) Role of prostaglandin E2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis. Eur J Cancer 42: 2382-2389.
18. Cozens AL, Yezzi MJ, Yamaya M, Steiger D, Wagner JA, et al. (1992) A transformed human epithelial cell line that retains tight junctions post crisis. In Vitro Cell Dev Biol 28A: 735-744.
19. Pace E, Ferraro M, Mody CH, Melis M, Bonanno A, et al. (2008) Pleural mesothelial cells express both BLT2 and PPARa and mount an integrated response to pleural LTB4. J Immunol 181: 7292-7299.
20. Kao CY, Kim C, Huang F, Wu R, (2008) Requirements for Two Proximal NF-κB Binding Sites and IκB-ζ in IL-17A-induced Human β-Defensin 2 Expression by Conducting Airway Epithelium. J Biol Chem 283: 15309-15318.
21. Imler JL, Hoffmann JA, (2001) Toll receptors in innate immunity. Trends Cell Biol 11: 304-311.
22. O'Donnell R, Breen D, Wilson S, Djukanovic R, (2006) Inflammatory cells in the airways in COPD. Thorax 61: 448-454.
23. Kim V, Rogers TJ, Criner GJ, (2008) New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 5: 478-485.
24. Pons J, Sauleda J, Regueiro V, Santos C, López M, et al. (2006) Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease. Respir Res 7: 64.
25. Droemann D, Goldmann T, Tiedje T, Zabel P, Dalhoff K, et al. (2005) Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res 6: 68.
26. Zhang X, Shan P, Jiang G, Cohn L, Lee PJ, (2006) Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116: 3050-3059.
27. Doz E, Noulin N, Boichot E, Guénon I, Fick L, et al. (2008) Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent. The Journal of Immunology 180: 1169-1178.
28. Curtis JL, Freeman CM, Hogg JC, (2007) The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proc Am Thorac Soc 4: 512-521.
29. MacRedmond R, Greene C, Taggart CC, McElvaney N, O'Neill S, (2005) Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide. Respir Res 6: 116.
30. Niyonsaba F, Ogawa H, Nagaoka I, (2004) Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology 111: 273-281.
31. Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, et al. (2002) Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298: 1025-1029.
32. Busacker A, Newell JD, Keefe T Jr, Hoffman EA, Granroth JC, et al. (2009) A Multivariate analysis of Risk factors for Air trapping Asthmatic phenotype as measured by quantitative CT analysis. Chest 135: 48-56.
33. Pace E, Ferraro M, Uasuf CG, Giarratano A, Grutta SL, et al. (2011) Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells. Cell Immunol 268: 47-53.
34. Herr C, Beisswenger C, Hess C, Kandler K, Suttorp NR, et al. for the CAPNETZ Study Group. (2009) Suppression of pulmonary innate host defence in smokers. Thorax 64: 144-149.
35. Fellerman K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, et al. (2006) A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J hum Genet 79: 439-448.
36. Kanda N, Watanabe S, (2008) Leptin enhances human beta-defensin-2 production in human keratinocytes. Endocrinology 149: 5189-5198.
37. Bruno A, Chanez P, Chiappara G, Siena L, Giammanco S, et al. (2005) Does leptin play a cytokine-like role within the airways of COPD patients? Eur Respir J 26: 398-405.
38. Cosio MG, Hale KA, Niewoehner DE, (1980) Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am Rev Respir Dis 122: 265-321.
39. Sethi S, Murphy MF, (2001) Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev 14: 336-363.
40. Pace E, Giarratano A, Ferraro M, Bruno A, Siena L, et al. (2011) TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure. Hum Immunol 72: 54-62.
41. Lapperre TS, Sont JK, van Schadewijk A, Gosman MM, Postma DS, et al. (2007) Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res 8: 85.