Distribution of new human β-defensin genes clustered on chromosome 20 in functionally different segments of epididymis

Genomics

Volumn 81, Issue 2, 2003, Pages 175-183

  Rodríguez Jiménez, Francisco Javier ^a   Krause, Alexander ^a   Schulz, Sandra ^a   Forssmann, Wolf Georg ^a   Conejo Garcia, José Ramón ^a   Schreeb, Rainer ^a   Motzkus, Dirk ^a  

^a IPF PHARMACEUTICALS GMBH   (Germany)

Author keywords

Chromosome 20; Cluster analysis; Epididymis; Expression; TaqMan; defensin

Indexed keywords

BETA DEFENSIN; COMPLEMENTARY DNA; MESSENGER RNA; PEPTIDE;

ARTICLE; BACTERIAL GROWTH; BETA DEFENSIN GENE; BIOINFORMATICS; CHROMOSOME 20; CHROMOSOME 20P; CONTROLLED STUDY; DNA DETERMINATION; EPIDIDYMIS; EPITHELIUM CELL; GENE; GENE CLUSTER; GENE LOCATION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MALE GENITAL SYSTEM; MOLECULAR CLONING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON MATURATION;

BACTERIA (MICROORGANISMS);

EID: 0037293097     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0888-7543(02)00034-4     Document Type: Article

References (35)

1. Lehrer R.I., Ganz T. Defensins of vertebrate animals. Curr. Opin. Immunol. 14:2002;96-102.
2. Yamaguchi Y., et al. Identification of multiple novel epididymis-specific β-defensin isoforms in humans and mice. J. Immunol. 169:2002;2516-2523.
3. Bensch K.W., Raida M., Magert H.J., Schulz-Knappe P., Forssmann W.G. hBD-1 a novel β-defensin from human plasma . FEBS Lett. 368:1995;331-335.
4. Harder J., Bartels J., Christophers E., Schroder J.M. A peptide antibiotic from human skin. Nature. 387:1997;861.
5. Harder J., Bartels J., Christophers E., Schroder J.M. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:2001;5707-5713.
6. Zhao C., Wang I., Lehrer R.I. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:1996;319-322.
7. McCray P.B. Jr., Bentley L. Human airway epithelia express a β-defensin. Am. J. Respir. Cell Mol. Biol. 16:1997;343-349.
8. Jia H.P., et al. Discovery of new human β-defensins using a genomics-based approach. Gene. 263:2001;211-218.
9. Garcia J.R., et al. Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res. 306:2001;257-264.
10. Garcia J.R., et al. Human β-defensin 4 a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity . FASEB J. 15:2001;1819-1821.
11. Frohlich O., Po C., Young L.G. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. Biol. Reprod. 64:2001;1072-1079.
12. Osterhoff C., Kirchhoff C., Krull N., Ivell R. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. Biol. Reprod. 50:1994;516-525.
13. Hamil K.G., et al. HE2β and HE2γ, new members of an epididymis-specific family of androgen-regulated proteins in the human. Endocrinology. 141:2000;1245-1253.
14. Perry A.C., Jones R., Moisyadi S., Coadwell J., Hall L. The novel epididymal secretory protein ESP13.2 in Macaca fascicularis. Biol. Reprod. 61:1999;965-972.
15. Yanagimachi R. Mammalian fertilization. Knobil E., Neill J.D. The Physiology of Reproduction. 1994;189-317 Raven Press, New York.
16. Moore H.D., Hartman T.D., Pryor J.P. Development of the oocyte-penetrating capacity of spermatozoa in the human epididymis. Int. J. Androl. 6:1983;310-318.
17. Moore H.D. Contribution of epididymal factors to sperm maturation and storage. Andrologia. 30:1998;233-239.
18. Yang D., et al. β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science. 286:1999;525-528.
19. Niyonsaba F., Iwabuchi K., Matsuda H., Ogawa H., Nagaoka I. Epithelial cell-derived human β-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. Int. Immunol. 14:2002;421-426.
20. Frye M., Bargon J., Gropp R. Expression of human β-defensin-1 promotes differentiation of keratinocytes. J. Mol. Med. 79:2001;275-282.
21. Schutte B.C., et al. Discovery of five conserved β-defensin gene clusters using a computational search strategy. Proc. Natl. Acad. Sci. USA. 99:2002;2129-2133.
22. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410. doi:10.1006/jmbi.1990.9999.
23. Nielsen H., Engelbrecht J., Brunak S., von Heijne G. A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Int. J. Neural. Syst. 8:1997;581-599.
24. Deloukas P., et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 414:2001;865-871.
25. Krull N., Ivell R., Osterhoff C., Kirchhoff C. Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs. Mol. Reprod. Dev. 34:1993;16-24.
26. Hwang P.M., Vogel H.J. Structure-function relationships of antimicrobial peptides. Biochem. Cell Biol. 76:1998;235-246.
27. Wilson C.L., et al. Regulation of intestinal β-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 286:1999;113-117.
28. Morrison G., Kilanowski F., Davidson D., Dorin J. Characterization of the mouse β-defensin 1, defb1, mutant mouse model. Infect. Immun. 70:2002;3053-3060.
29. Yamaguchi Y., et al. A novel mouse β-defensin, mBD-6, predominantly expressed in skeletal muscle. J. Biol. Chem. 276:2001;31510-31514.
30. Li P., et al. An antimicrobial peptide gene found in the male reproductive system of rats. Science. 291:2001;1783-1785.
31. Von Horsten H.H., Derr P., Kirchhoff C. Novel antimicrobial peptide of human epididymal duct origin. Biol. Reprod. 67:2002;804-813.
32. Cornwall G.A., Hann S.R. Specialized gene expression in the epididymis. J. Androl. 16:1995;379-383.
33. Pera I., Ivell R., Kirchhoff C. Regional variation of specific gene expression in the dog epididymis as revealed by in-situ transcript hybridization. Int. J. Androl. 17:1994;324-330.
34. Gould K.G., Young L.G. Acquisition of fertilizing capacity by chimpanzee sperm. Folia Primatol. 54:1990;105-108.
35. Sobotta, J., Brust, Bauch, Becken, untere Extremität, in: J. Staubesand (Ed.), Sobotta/Atlas der Anatomie des Menschen, Bd. 2, Urban & Schwarzenberg, Munich, Germany, 1988, p. 227.