Genetic variants of human β-defensin-1 and chronic obstructive pulmonary disease

Biochemical and Biophysical Research Communications

Volumn 291, Issue 1, 2002, Pages 17-22

  Matsushita, Ikumi ^a,b   Hasegawa, Kyoko ^a   Nakata, Koh ^a   Yasuda, Kazuki ^a   Tokunaga, Katsushi ^b   Keicho, Naoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Association study; Chronic bronchitis; COPD; Defensin; Genetic susceptibility

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 1; DNA; ISOLEUCINE; NUCLEOTIDE; UNCLASSIFIED DRUG;

ADULT; AGED; AIRWAY; ANTIMICROBIAL ACTIVITY; ARTICLE; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; FOLLOW UP; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM; SPUTUM ANALYSIS; UNTRANSLATED REGION;

EID: 0036088757     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6395     Document Type: Article

References (29)

1. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary
2. Evidence-based health policy-lessons from the Global Burden of Disease Study
3. Genetic risk factors for chronic obstructive pulmonary disease
4. Molecular genetics of chronic obstructive pulmonary disease
5. The electrophoretic alpha 1 globulin pattern of serum in alpha1-antitrypsin deficiency
6. A leucine-to-proline substitution causes a defective alpha1-antichymotrypsin allele associate with familial obstructive lung disease
7. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
8. Glutathione S-transferase P-1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease
9. Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: Combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1
10. Tumor necrosis factor-α gene polymorphism in chronic bronchitis
11. Vitamin D binding protein variants and the risk of COPD
12. The natural history of forced expiratory volumes. Effect of cigarette smoking and respiratory symptoms
13. Bacterial infection and the pathogenesis of COPD
14. A peptide antibiotic from human skin
15. Defensins and host defense
16. Expression of mammalian defensin genes
17. Human airway epithelia express a β-defensin
18. Production of β-defensins by human airway epithelia
19. β-Defensins: Endogenous antibiotics of the innate host defense response
20. Polymorphisms of the human β-defensin-1 gene
21. Purification of genomic DNA from human whole blood by isopropanol-fractionation with concentrated NaI and SDS
22. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease
23. Human beta defensin 1 gene six new variants
24. Antimicrobial peptides in mammalian and insect host defence
25. Innate immunity
26. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
27. The structure of human beta-defensin-2 shows evidence of higher order oligomerization
28. Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
29. Possibility of a dominant negative effect of some point mutations