Legionella pneumophila induces human beta Defensin-3 in pulmonary cells

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Scharf, Stefanie ^a   Vardarova, Kremena ^a   Lang, Friederike ^a   Schmeck, Bernd ^a   Opitz, Bastian ^a   Flieger, Antje ^b   Heuner, Klaus ^b   Hippenstiel, Stefan ^a   Suttorp, Norbert ^a   N'Guessan, Philippe D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C JUN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; BETA DEFENSIN; BETA DEFENSIN 3, HUMAN; BETA-DEFENSIN 3, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR AP 1;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MICROBIOLOGY; PATHOGENICITY; RESPIRATORY TRACT MUCOSA; TIME; UPREGULATION;

BETA-DEFENSINS; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; IMMUNITY, INNATE; LEGIONELLA PNEUMOPHILA; MACROPHAGES, ALVEOLAR; MAP KINASE KINASE 4; NF-KAPPA B; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 77956682605     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-93     Document Type: Article

References (37)

1. von Baum H, Ewig S, Marre R, Suttorp N, Gonschior S, Welte T, Luck C. Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia. Clin Infect Dis 2008, 46:1356-1364. 4, 10.1086/586741, 18419436.
2. Hippenstiel S, Opitz B, Schmeck B, Suttorp N. Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res 2006, 7:97. 10.1186/1465-9921-7-97, 1533821, 16827942.
3. Cianciotto NP. Many substrates and functions of type II secretion: lessons learned from Legionella pneumophila. Future Microbiol 2009, 4:797-805. 10.2217/fmb.09.53, 2754693, 19722835.
4. Isberg RR, O'Connor TJ, Heidtman M. The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol 2009, 7:13-24. 24, 10.1038/nrmicro1967, 2631402, 19011659.
5. Bhan U, Trujillo G, Lyn-Kew K, Newstead MW, Zeng X, Hogaboam CM, Krieg AM, Standiford TJ. Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Infect Immun 2008, 76:2895-2904. 10.1128/IAI.01489-07, 2446723, 18426877.
6. Girard RF, Pedron TF, Uematsu VS, Balloy VF, Balloy MF, Chignard R, Akira S, Chaby R. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 2003, 116:293-302. 10.1242/jcs.00212, 12482915.
7. Hawn TR, Verbon A, Lettinga DK, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003, 198:1563-1572. 10.1084/jem.20031220, 2194120, 14623910.
8. Hiemstra PS. The role of epithelial beta-defensins and cathelicidins in host defense of the lung. Exp Lung Res 2007, 33:537-542. 47, 10.1080/01902140701756687, 18075828.
9. McCray PB, Bentley L. Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol 1997, 16:343-349.
10. Bals R, Wang X, Z W, Freeman T, Bafna V, Zasloff M, Wilson JM. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998, 102:874-880. 10.1172/JCI2410, 508952, 9727055.
11. Harder J, Bartels J, Christophers E, Schroder JM. A peptide antibiotic from human skin. Nature 1997, 387:861. 10.1038/43088, 9202117.
12. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001, 276:5707-5713. 10.1074/jbc.M008557200, 11085990.
13. Maisetta G, Batoni G, Esin S, Florio W, Bottai D, Favilli F, Campa M. In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob Agents Chemother 2006, 50:806-809. 10.1128/AAC.50.2.806-809.2006, 1366902, 16436752.
14. Ishimoto H, Mukae H, Date Y, Shimbara T, Mondal MS, Ashitani J, Hiratsuka T, Kubo S, Kohno S, Nakazato M. Identification of hBD-3 in respiratory tract and serum: the increase in pneumonia. Eur Respir J 2006, 27:253-260. 10.1183/09031936.06.00105904, 16452577.
15. Albanesi C, Fairchild HR, Madonna S, Scarponi C, De Pita O, Leung DY, Howell MD. IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol 2007, 179:984-992.
16. Menzies BE, Kenoyer A. Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun 2006, 74:6847-6854. 10.1128/IAI.00389-06, 1698080, 16954397.
17. Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig KH, Schubert S, Schreiber S, Folsch UR, Rosenstiel P, Arlt A. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol 2009, 10:36. 10.1186/1471-2172-10-36, 2702365, 19523197.
18. Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol 2003, 23:2871-2882. 10.1128/MCB.23.8.2871-2882.2003, 152565, 12665585.
19. Lippmann J, Rothenburg S, Deigendesch N, Eitel J, van Meixenberger KLV, Slevogt H, N'Guessan PD, Hippenstiel S, Chakraborty T, Flieger A, Suttorp N, Opitz B. IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol 2008, 10:2579-2588. 10.1111/j.1462-5822.2008.01232.x, 18771559.
20. N'Guessan PD, Etouem MO, Schmeck B, Hocke AC, Scharf S, Vardarova K, Opitz B, Flieger A, Suttorp N, Hippenstiel S. Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2007, 292:L267-L277. 10.1152/ajplung.00100.2006, 17012371.
21. Schmeck B, Lorenz J, N'Guessan PD, Opitz B, van LV, Zahlten J, Slevogt H, Witzenrath M, Flieger A, Suttorp N, Hippenstiel S. Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. J Immunol 2008, 181:940-947.
22. Edelstein PH. Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens. J Clin Microbiol 1981, 14:298-303. 578, 271958, 7287886.
23. Islam D, Bandholtz L, Nilsson J, Wigzell H, Christensson B, Agerberth B, Gudmundsson G. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001, 7:180-185. 172, 10.1038/84627, 11175848.
24. Scharf S, Hippenstiel S, Flieger A, Suttorp N, N'Guessan PD. Induction of human {beta}-Defensin-2 in pulmonary epithelial cells by Legionella pneumophila: Involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-{kappa}B and AP-1. Am J Physiol Lung Cell Mol Physiol 2010, 298:687-695.
25. Li W, Zheng S, Tang C, Zhu Y, Wang X. JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides 2007, 28:1252-1259. 10.1016/j.peptides.2007.03.021, 17481780.
26. Sabria M, Pedro-Botet ML, Gomez J, Roig J, Vilaseca B, Sopena N, Banos V. Fluoroquinolones vs macrolides in the treatment of Legionnaires disease. Chest 2005, 128:1401-1405. 10.1378/chest.128.3.1401, 16162735.
27. Rivas-Santiago B, Schwander SK, Sarabia C, Diamond G, Klein-Patel ME, Hernandez-Pando R, Ellner JJ, Sada E. Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect Immun 2005, 73:4505-4511. 10.1128/IAI.73.8.4505-4511.2005, 1201238, 16040961.
28. Sawamura D, Goto M, Shibaki A, Akiyama M, McMillan JR, Abiko Y, Shimizu H. Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Gene Ther 2005, 12:857-861. 10.1038/sj.gt.3302472, 15729370.
29. Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, Harding CV, Weinberg A, Sieg SF. Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci USA 2007, 104:18631-18635. 10.1073/pnas.0702130104, 2141828, 18006661.
30. Fahlgren A, Hammarstrom S, Danielsson A, Hammarstrom ML. beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol 2004, 137:379-385. 10.1111/j.1365-2249.2004.02543.x, 1809118, 15270856.
31. Lu Q, Samaranayake LP, Darveau RP, Jin L. Expression of human beta-defensin-3 in gingival epithelia. J Periodontal Res 2005, 40:474-481. 10.1111/j.1600-0765.2005.00827.x, 16302926.
32. Kawsar HI, Weinberg A, Hirsch SA, Venizelos A, Howell S, Jiang B, Jin G. Overexpression of human beta-defensin-3 in oral dysplasia: potential role in macrophage trafficking. Oral Oncol 2009, 45:696-702. 2, 10.1016/j.oraloncology.2008.10.016, 19097930.
33. Buchau AS, Schauber J, Hultsch T, Stuetz A, Gallo RL. Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. J Invest Dermatol 2008, 128:2646-2654. 10.1038/jid.2008.135, 2639780, 18496569.
34. Sumikawa YF, Asada HF, Hoshino KF, Azukizawa HF, Katayama IF, Akira S, Itami S. Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2. Microbes Infect 2(8):1513-1521.
35. Fuse ET, Tateda K, Kikuchi Y, Matsumoto T, Gondaira F, Azuma A, Kudoh S, Standiford TJ, Yamaguchi K. Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model. J Med Microbiol 2007, 56:305-312. 10.1099/jmm.0.46913-0, 17314358.
36. Kao YJ, Piedra PA, Larsen GL, Colasurdo GN. Induction and regulation of nitric oxide synthase in airway epithelial cells by respiratory syncytial virus. Am J Respir Crit Care Med 2001, 163:532-539.
37. Vardarova K, Scharf S, Lang F, Schmeck B, Opitz B, Eitel J, Hocke AC, Slevogt H, Flieger A, Hippenstiel S, Suttorp N, N'Guessan PD. PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF. Eur Respir J 2009, 34:1171-1179. 10.1183/09031936.00171908, 19324950.