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Volumn 19, Issue 8, 2013, Pages 1412-1424

Role of cell cycle biomarkers in human papillomavirus related uterine lesions

Author keywords

Cervical carcinoma; Cyclin D1; Human papillomavirus; Ki67; p16; p53; ProEx C; Squamous intraepithelial lesion

Indexed keywords

BIOLOGICAL MARKER; CYCLIN D1; CYCLIN E; CYCLINE; DNA TOPOISOMERASE (ATP HYDROLYSING); KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN P16; PROTEIN P53; TRANSCRIPTION FACTOR E2F; VIRUS DNA;

EID: 84876743247     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161213804805450     Document Type: Article
Times cited : (9)

References (115)
  • 2
    • 0031661287 scopus 로고    scopus 로고
    • Death of the Papanicolaou smear? A tale of three reasons
    • Boronow RC. Death of the Papanicolaou smear? A tale of three reasons. Am J Obstet Gynecol 1998; 179: 391-6.
    • (1998) Am J Obstet Gynecol , vol.179 , pp. 391-396
    • Boronow, R.C.1
  • 3
    • 0001814539 scopus 로고    scopus 로고
    • The Pap smear
    • In: DeMay RM. Eds, Chicago: American Society of Clinical Pathologists Press
    • DeMay RM. The Pap smear. In: DeMay RM. Eds. The art and science of cytopathology. Chicago: American Society of Clinical Pathologists Press 1996; pp. 61-205.
    • (1996) The art and science of cytopathology , pp. 61-205
    • DeMay, R.M.1
  • 4
    • 33646675570 scopus 로고    scopus 로고
    • Molecular biology of human papillomavirus infection and cervical cancer
    • Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond) 2006; 110: 525-41.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 525-541
    • Doorbar, J.1
  • 5
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2: 342-50.
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 6
    • 0036364468 scopus 로고    scopus 로고
    • Immune evasion in human papillomavirus-associated cervical cancer
    • Tindle RW. Immune evasion in human papillomavirus-associated cervical cancer. Nat Rev Cancer 2002; 2:59-65.
    • (2002) Nat Rev Cancer , vol.2 , pp. 59-65
    • Tindle, R.W.1
  • 7
    • 33845905779 scopus 로고    scopus 로고
    • The natural history of cervical HPV infection: Unresolved issues
    • Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 2007; 7: 11-22.
    • (2007) Nat Rev Cancer , vol.7 , pp. 11-22
    • Woodman, C.B.1    Collins, S.I.2    Young, L.S.3
  • 8
    • 0037165740 scopus 로고    scopus 로고
    • The 2001 Bethesda System: Terminology for reporting results of cervical cytology
    • Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 2002; 287: 2114-9.
    • (2002) JAMA , vol.287 , pp. 2114-2119
    • Solomon, D.1    Davey, D.2    Kurman, R.3
  • 10
    • 0032169416 scopus 로고    scopus 로고
    • Coexistence of low and high grade squamous intraepithelial lesions of the cervix: Morphologic progression or multiple papillomaviruses?
    • Park J, Sun D, Genest DR, Trivijitsilp P, Suh I, Crum CP. Coexistence of low and high grade squamous intraepithelial lesions of the cervix: morphologic progression or multiple papillomaviruses? Gynecol Oncol 1998; 70: 386-91.
    • (1998) Gynecol Oncol , vol.70 , pp. 386-391
    • Park, J.1    Sun, D.2    Genest, D.R.3    Trivijitsilp, P.4    Suh, I.5    Crum, C.P.6
  • 11
    • 84861321837 scopus 로고    scopus 로고
    • Cervical precancer, including functional biomarkers and colposcopy
    • In: Robboy SL, Mutter GL, Prat J, Bently RC, Russell P, Anderson MC Eds, New York: Churchill Livingstone
    • Baak JPA, Stoler MH, Bean SM, Anderson MC, Robboy SJ. Cervical precancer, including functional biomarkers and colposcopy. In: Robboy SL, Mutter GL, Prat J, Bently RC, Russell P, Anderson MC Eds. Pathology of the Female Reproductive Tract. New York: Churchill Livingstone 2009; pp.189-226.
    • (2009) Pathology of the Female Reproductive Tract , pp. 189-226
    • Baak, J.P.A.1    Stoler, M.H.2    Bean, S.M.3    Anderson, M.C.4    Robboy, S.J.5
  • 12
    • 3242723235 scopus 로고    scopus 로고
    • The cervical cancer epidemic that screening has prevented in the UK
    • Peto J, Gilham C, Fletcher O, Matthews FE. The cervical cancer epidemic that screening has prevented in the UK. Lancet 2004; 364: 249-56.
    • (2004) Lancet , vol.364 , pp. 249-256
    • Peto, J.1    Gilham, C.2    Fletcher, O.3    Matthews, F.E.4
  • 14
    • 0142062150 scopus 로고    scopus 로고
    • Chapter 1: Human papillomavirus and cervical cancer--burden and assessment of causality
    • Bosch FX, de Sanjosé S. Chapter 1: Human papillomavirus and cervical cancer--burden and assessment of causality. J Natl Cancer Inst Monogr 2003; 31: 3-13.
    • (2003) J Natl Cancer Inst Monogr , vol.31 , pp. 3-13
    • Bosch, F.X.1    de Sanjosé, S.2
  • 15
    • 0033572319 scopus 로고    scopus 로고
    • Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes
    • Klaes R, Woerner SM, Ridder R, et al. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999; 59: 6132-6.
    • (1999) Cancer Res , vol.59 , pp. 6132-6136
    • Klaes, R.1    Woerner, S.M.2    Ridder, R.3
  • 16
    • 0034032598 scopus 로고    scopus 로고
    • Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix
    • Duggan MA. Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix. Mod Pathol 2000; 13: 252-60.
    • (2000) Mod Pathol , vol.13 , pp. 252-260
    • Duggan, M.A.1
  • 17
    • 0020641547 scopus 로고
    • Atypical immature metaplasia (AIM). A subset of human papilloma virus infection of the cervix
    • Crum CP, Egawa K, Fu YS, et al. Atypical immature metaplasia (AIM). A subset of human papilloma virus infection of the cervix. Cancer 1983; 51: 2214-9.
    • (1983) Cancer , vol.51 , pp. 2214-2219
    • Crum, C.P.1    Egawa, K.2    Fu, Y.S.3
  • 18
    • 33750051084 scopus 로고    scopus 로고
    • Atypical immature cervical metaplasia: Immunoprofiling and longitudinal outcome
    • Duggan MA, Akbari M, Magliocco AM. Atypical immature cervical metaplasia: immunoprofiling and longitudinal outcome. Hum Pathol 2006; 37: 1473-81.
    • (2006) Hum Pathol , vol.37 , pp. 1473-1481
    • Duggan, M.A.1    Akbari, M.2    Magliocco, A.M.3
  • 19
    • 34548736601 scopus 로고    scopus 로고
    • p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: Correlation with human papillomavirus detection
    • Iaconis L, Hyjek E, Ellenson LH, et al. p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. Arch Pathol Lab Med 2007; 131: 1343-1349.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1343-1349
    • Iaconis, L.1    Hyjek, E.2    Ellenson, L.H.3
  • 20
    • 0033018699 scopus 로고    scopus 로고
    • Atypical immature metaplasia (AIM) of the cervix: Is it related to high-grade squamous intraepithelial lesion (HSIL)?
    • Geng L, Connolly DC, Isacson C, et al. Atypical immature metaplasia (AIM) of the cervix: is it related to high-grade squamous intraepithelial lesion (HSIL)? Hum Pathol 1999; 30: 345-351.
    • (1999) Hum Pathol , vol.30 , pp. 345-351
    • Geng, L.1    Connolly, D.C.2    Isacson, C.3
  • 21
    • 69849109598 scopus 로고    scopus 로고
    • Effect of human papillomavirus on cell cycle-related proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in precursor lesions of cervical carcinoma: A tissue microarray study
    • Conesa-Zamora P, Doménech-Peris A, Orantes-Casado FJ, et al. Effect of human papillomavirus on cell cycle-related proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in precursor lesions of cervical carcinoma: a tissue microarray study. Am J Clin Pathol 2009; 132: 378-90.
    • (2009) Am J Clin Pathol , vol.132 , pp. 378-390
    • Conesa-Zamora, P.1    Doménech-Peris, A.2    Orantes-Casado, F.J.3
  • 22
    • 0031820725 scopus 로고    scopus 로고
    • Cytologic correlates of papillary immature metaplasia (immature condyloma) of the cervix
    • Mosher RE, Lee KR, Trivijitsilp P, Crum CP. Cytologic correlates of papillary immature metaplasia (immature condyloma) of the cervix. Diagn Cytopathol 1998; 18: 416-21.
    • (1998) Diagn Cytopathol , vol.18 , pp. 416-421
    • Mosher, R.E.1    Lee, K.R.2    Trivijitsilp, P.3    Crum, C.P.4
  • 23
    • 84862912878 scopus 로고    scopus 로고
    • p16(INK4a) and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based Papanicolaou tests with menstrual contamination
    • Ge Y, Mody DR, Smith D, Anton R. p16(INK4a) and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based Papanicolaou tests with menstrual contamination. Acta Cytol 2012; 56: 55-61.
    • (2012) Acta Cytol , vol.56 , pp. 55-61
    • Ge, Y.1    Mody, D.R.2    Smith, D.3    Anton, R.4
  • 25
    • 34447515192 scopus 로고    scopus 로고
    • Accuracy of liquid based versus conventional cytology: Overall results of new technologies for cervical cancer screening: Randomised controlled trial
    • Ronco G, Cuzick J, Pierotti P, et al. Accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening: randomised controlled trial. BMJ 2007; 335: 28.
    • (2007) BMJ , vol.335 , pp. 28
    • Ronco, G.1    Cuzick, J.2    Pierotti, P.3
  • 26
    • 0037832461 scopus 로고    scopus 로고
    • Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy
    • ASCUS-LSIL Triage Study (ALTS) Group
    • Cox JT, Schiffman M, Solomon D; ASCUS-LSIL Triage Study (ALTS) Group. Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy. Am J Obstet Gynecol 2003; 188: 1406-12.
    • (2003) Am J Obstet Gynecol , vol.188 , pp. 1406-1412
    • Cox, J.T.1    Schiffman, M.2    Solomon, D.3
  • 27
    • 0041622838 scopus 로고    scopus 로고
    • Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization
    • Costa S, De Simone P, Venturoli S, et al. Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization. Gynecol Oncol 2003; 90: 358-65.
    • (2003) Gynecol Oncol , vol.90 , pp. 358-365
    • Costa, S.1    De Simone, P.2    Venturoli, S.3
  • 28
    • 0035832483 scopus 로고    scopus 로고
    • Natural history of cervical human papillomavirus infection in young women: A longitudinal cohort study
    • Woodman CB, Collins S, Winter H, et al. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet 2001; 357: 1831-6.
    • (2001) Lancet , vol.357 , pp. 1831-1836
    • Woodman, C.B.1    Collins, S.2    Winter, H.3
  • 29
    • 0037048697 scopus 로고    scopus 로고
    • Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: Comparison of sensitivity, specificity, and frequency of referral
    • Kulasingam SL, Hughes JP, Kiviat NB, et al. Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. JAMA 2002; 288: 1749-57.
    • (2002) JAMA , vol.288 , pp. 1749-1757
    • Kulasingam, S.L.1    Hughes, J.P.2    Kiviat, N.B.3
  • 30
    • 0037058719 scopus 로고    scopus 로고
    • Recurrent human papillomavirus infection detected with the hybrid capture II assay selects women with normal cervical smears at risk for developing high grade cervical lesions: A longitudinal study of 3,091 women
    • Bory JP, Cucherousset J, Lorenzato M, et al. Recurrent human papillomavirus infection detected with the hybrid capture II assay selects women with normal cervical smears at risk for developing high grade cervical lesions: a longitudinal study of 3,091 women. Int J Cancer 2002; 102: 519-25.
    • (2002) Int J Cancer , vol.102 , pp. 519-525
    • Bory, J.P.1    Cucherousset, J.2    Lorenzato, M.3
  • 31
    • 13744258937 scopus 로고    scopus 로고
    • A study of the impact of adding HPV types to cervical cancer screening and triage tests
    • Schiffman M, Khan MJ, Solomon D, et al. A study of the impact of adding HPV types to cervical cancer screening and triage tests. J Natl Cancer Inst 2005; 97: 147-50.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 147-150
    • Schiffman, M.1    Khan, M.J.2    Solomon, D.3
  • 32
    • 0037421589 scopus 로고    scopus 로고
    • Epidemiologic classification of human papillomavirus types associated with cervical cancer
    • Muñoz N, Bosch FX, de Sanjosé S, et al; for the International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-527.
    • (2003) N Engl J Med , vol.348 , pp. 518-527
    • Muñoz, N.1    Bosch, F.X.2    de Sanjosé, S.3
  • 33
    • 69549130864 scopus 로고    scopus 로고
    • Genotype distribution of human papillomavirus (HPV) and co-infections in cervical cytologic specimens from two outpatient gynecological clinics in a region of southeast Spain
    • Conesa-Zamora P, Ortiz-Reina S, Moya-Biosca J, et al. Genotype distribution of human papillomavirus (HPV) and co-infections in cervical cytologic specimens from two outpatient gynecological clinics in a region of southeast Spain. BMC Infect Dis 2009; 9: 124.
    • (2009) BMC Infect Dis , vol.9 , pp. 124
    • Conesa-Zamora, P.1    Ortiz-Reina, S.2    Moya-Biosca, J.3
  • 34
    • 57649110514 scopus 로고    scopus 로고
    • HPV in situ hybridization signal patterns as a marker for cervical intraepithelial neoplasia progression
    • De Marchi Triglia R, Metze K, Zeferino LC, Lucci De Angelo Andrade LA. HPV in situ hybridization signal patterns as a marker for cervical intraepithelial neoplasia progression. Gynecol Oncol 2009; 112: 114-8.
    • (2009) Gynecol Oncol , vol.112 , pp. 114-118
    • De Marchi Triglia, R.1    Metze, K.2    Zeferino, L.C.3    Lucci De Angelo Andrade, L.A.4
  • 35
    • 42749095849 scopus 로고    scopus 로고
    • P16 expression in relation to human papillomavirus in liquid-based cervical smears
    • Samama B, Schaeffer C, Boehm N. P16 expression in relation to human papillomavirus in liquid-based cervical smears. Gynecol Oncol 2008; 109: 285-90.
    • (2008) Gynecol Oncol , vol.109 , pp. 285-290
    • Samama, B.1    Schaeffer, C.2    Boehm, N.3
  • 36
    • 0038792816 scopus 로고    scopus 로고
    • Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: Results for 8466 patients
    • Petry KU, Menton S, Menton M, et al. Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients. Br J Cancer 2003; 88: 1570-7.
    • (2003) Br J Cancer , vol.88 , pp. 1570-1577
    • Petry, K.U.1    Menton, S.2    Menton, M.3
  • 37
    • 77953013051 scopus 로고    scopus 로고
    • High-risk HPV testing in women 30 years or older with negative Papanicolaou tests: Initial clinical experience with 18-month follow-up
    • Thrall MJ, Russell DK, Facik MS, et al. High-risk HPV testing in women 30 years or older with negative Papanicolaou tests: initial clinical experience with 18-month follow-up. Am J Clin Pathol 2010; 133: 894-8.
    • (2010) Am J Clin Pathol , vol.133 , pp. 894-898
    • Thrall, M.J.1    Russell, D.K.2    Facik, M.S.3
  • 38
    • 34250836496 scopus 로고    scopus 로고
    • The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma
    • Bahnassy AA, Zekri AR, Saleh M, et al. The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. BMC Clin Pathol 2007; 7: 4.
    • (2007) BMC Clin Pathol , vol.7 , pp. 4
    • Bahnassy, A.A.1    Zekri, A.R.2    Saleh, M.3
  • 39
    • 1642316853 scopus 로고    scopus 로고
    • Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm
    • Tsuda H, Hashiguchi Y, Nishimura S, et al. Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm. Gynecol Oncol 2003; 91: 476-485.
    • (2003) Gynecol Oncol , vol.91 , pp. 476-485
    • Tsuda, H.1    Hashiguchi, Y.2    Nishimura, S.3
  • 40
    • 78649904253 scopus 로고    scopus 로고
    • The value of p16ink4a expression by fluorescence in situ hybridization in triage for high risk HPV positive in cervical cancer screening
    • Zeng WJ, Li Y, Fei HL, et al. The value of p16ink4a expression by fluorescence in situ hybridization in triage for high risk HPV positive in cervical cancer screening. Gynecol Oncol 2011; 120: 84-8.
    • (2011) Gynecol Oncol , vol.120 , pp. 84-88
    • Zeng, W.J.1    Li, Y.2    Fei, H.L.3
  • 41
    • 0028348414 scopus 로고
    • Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types
    • Zur Hausen H. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol 1994; 186: 131-156.
    • (1994) Curr Top Microbiol Immunol , vol.186 , pp. 131-156
    • Zur Hausen, H.1
  • 42
    • 20844443130 scopus 로고    scopus 로고
    • p16INK4A, CDC6, and MCM5: Predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
    • Murphy N, Ring M, Heffron CC, et al. p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J Clin Pathol 2005;58:525-34.
    • (2005) J Clin Pathol , vol.58 , pp. 525-534
    • Murphy, N.1    Ring, M.2    Heffron, C.C.3
  • 43
    • 33845969200 scopus 로고    scopus 로고
    • The expressions of the Rb pathway in cervical intraepithelial neoplasia: Predictive and prognostic significance
    • Nam EJ, Kim JW, Kim SW, et al. The expressions of the Rb pathway in cervical intraepithelial neoplasia: predictive and prognostic significance. Gynecol Oncol 2007; 104: 207-211.
    • (2007) Gynecol Oncol , vol.104 , pp. 207-211
    • Nam, E.J.1    Kim, J.W.2    Kim, S.W.3
  • 44
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998; 153: 1741-8.
    • (1998) Am J Pathol , vol.153 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3
  • 45
    • 41349087575 scopus 로고    scopus 로고
    • Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling
    • Branca M, Ciotti M, Giorgi C, et al. Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. Int J Gynecol Pathol 2008; 27: 265-73.
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 265-273
    • Branca, M.1    Ciotti, M.2    Giorgi, C.3
  • 46
    • 15544371798 scopus 로고    scopus 로고
    • Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies
    • Nieh S, Chen SF, Chu TY, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol 2005; 97: 35-40.
    • (2005) Gynecol Oncol , vol.97 , pp. 35-40
    • Nieh, S.1    Chen, S.F.2    Chu, T.Y.3
  • 47
    • 33644554478 scopus 로고    scopus 로고
    • p16INK4A expression in cervical premalignant and malignant lesions
    • Lambert AP, Anschau F, Schmitt VM. p16INK4A expression in cervical premalignant and malignant lesions. Exp Mol Pathol 2006; 80: 192-6.
    • (2006) Exp Mol Pathol , vol.80 , pp. 192-196
    • Lambert, A.P.1    Anschau, F.2    Schmitt, V.M.3
  • 48
    • 0034927426 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPVnegative cervical adenocarcinomas
    • Milde-Langosch K, Riethdorf S, Kraus-Pöppinghaus A, Riethdorf L, Löning T. Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPVnegative cervical adenocarcinomas. Virchows Arch 2001; 439: 55-61.
    • (2001) Virchows Arch , vol.439 , pp. 55-61
    • Milde-Langosch, K.1    Riethdorf, S.2    Kraus-Pöppinghaus, A.3    Riethdorf, L.4    Löning, T.5
  • 49
    • 1842583607 scopus 로고    scopus 로고
    • Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer
    • Wang JL, Zheng BY, Li XD, Angström T, Lindström MS, Wallin KL. Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer. Clin Cancer Res 2004; 10: 2407-14.
    • (2004) Clin Cancer Res , vol.10 , pp. 2407-2414
    • Wang, J.L.1    Zheng, B.Y.2    Li, X.D.3    Angström, T.4    Lindström, M.S.5    Wallin, K.L.6
  • 50
    • 84856109960 scopus 로고    scopus 로고
    • P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas
    • Huang LW, Lee CC. P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas. J Clin Pathol 2012; 65: 117-21.
    • (2012) J Clin Pathol , vol.65 , pp. 117-121
    • Huang, L.W.1    Lee, C.C.2
  • 51
    • 55849088380 scopus 로고    scopus 로고
    • Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    • Szarewski A, Ambroisine L, Cadman L, et al. Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears. Cancer Epidemiol Biomarkers Prev 2008; 17: 3033-42.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 3033-3042
    • Szarewski, A.1    Ambroisine, L.2    Cadman, L.3
  • 52
    • 77956650797 scopus 로고    scopus 로고
    • Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results
    • Reuschenbach M, Clad A, von Knebel Doeberitz C, et al. Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results. Gynecol Oncol 2010; 119: 98-105.
    • (2010) Gynecol Oncol , vol.119 , pp. 98-105
    • Reuschenbach, M.1    Clad, A.2    von Knebel Doeberitz, C.3
  • 53
    • 33947670404 scopus 로고    scopus 로고
    • CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III)
    • Regauer S, Reich O. CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology 2007; 50: 629-35.
    • (2007) Histopathology , vol.50 , pp. 629-635
    • Regauer, S.1    Reich, O.2
  • 54
    • 83655167360 scopus 로고    scopus 로고
    • Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki-67 in epithelial cells
    • Reuschenbach M, Seiz M, von Knebel Doeberitz C, et al. Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki-67 in epithelial cells. Int J Cancer 2012; 130: 388-94.
    • (2012) Int J Cancer , vol.130 , pp. 388-394
    • Reuschenbach, M.1    Seiz, M.2    von Knebel Doeberitz, C.3
  • 55
    • 75949096899 scopus 로고    scopus 로고
    • Papillary squamous intraepithelial lesions of the uterine cervix: Human papillomavirus-dependent changes in cell cycle expression and cytologic features
    • Liang CW, Lin MC, Hsiao CH, Lin YT, Kuo KT. Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features. Hum Pathol 2010; 41: 326-35.
    • (2010) Hum Pathol , vol.41 , pp. 326-335
    • Liang, C.W.1    Lin, M.C.2    Hsiao, C.H.3    Lin, Y.T.4    Kuo, K.T.5
  • 56
    • 33750817623 scopus 로고    scopus 로고
    • Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence
    • Zhao P, Mao X, Talbot IC. Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence. World J Gastroenterol 2006; 12: 6391-6.
    • (2006) World J Gastroenterol , vol.12 , pp. 6391-6396
    • Zhao, P.1    Mao, X.2    Talbot, I.C.3
  • 57
    • 0031771435 scopus 로고    scopus 로고
    • Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation
    • Emig R, Magener A, Ehemann V, et al. Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation. Br J Cancer 1998; 78: 1661-8.
    • (1998) Br J Cancer , vol.78 , pp. 1661-1668
    • Emig, R.1    Magener, A.2    Ehemann, V.3
  • 59
    • 77951067833 scopus 로고    scopus 로고
    • Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation
    • Zhao CY, Szekely L, Bao W, Selivanova G. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res 2010; 70: 3372-81.
    • (2010) Cancer Res , vol.70 , pp. 3372-3381
    • Zhao, C.Y.1    Szekely, L.2    Bao, W.3    Selivanova, G.4
  • 60
    • 9944260473 scopus 로고    scopus 로고
    • Expression of p53, Ki-67, and CD31 in the vaginal margins of radical hysterectomy in patients with stage IB carcinoma of the cervix
    • Silva-Filho AL, Traiman P, Triginelli SA, et al. Expression of p53, Ki-67, and CD31 in the vaginal margins of radical hysterectomy in patients with stage IB carcinoma of the cervix. Gynecol Oncol 2004; 95: 646-654.
    • (2004) Gynecol Oncol , vol.95 , pp. 646-654
    • Silva-Filho, A.L.1    Traiman, P.2    Triginelli, S.A.3
  • 61
    • 0141645604 scopus 로고    scopus 로고
    • Cooverexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix
    • Grace VM, Shalini JV, Lekha TT, Devaraj SN, Devaraj H. Cooverexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2003; 91: 51-8.
    • (2003) Gynecol Oncol , vol.91 , pp. 51-58
    • Grace, V.M.1    Shalini, J.V.2    Lekha, T.T.3    Devaraj, S.N.4    Devaraj, H.5
  • 62
    • 0032884699 scopus 로고    scopus 로고
    • Proto-oncogenes and p53 protein expression in normal cervical stratified squamous epithelium and cervical intra-epithelial neoplasia
    • Ngan HY, Liu SS, Yu H, Liu KL, Cheung AN. Proto-oncogenes and p53 protein expression in normal cervical stratified squamous epithelium and cervical intra-epithelial neoplasia. Eur J Cancer 1999; 35: 1546-50.
    • (1999) Eur J Cancer , vol.35 , pp. 1546-1550
    • Ngan, H.Y.1    Liu, S.S.2    Yu, H.3    Liu, K.L.4    Cheung, A.N.5
  • 63
    • 33746408518 scopus 로고    scopus 로고
    • Comparative analysis of 19 genital human papillomavirus types with regard to p53 degradation, immortalization, phylogeny, and epidemiologic risk classification
    • Hiller T, Poppelreuther S, Stubenrauch F, et al. Comparative analysis of 19 genital human papillomavirus types with regard to p53 degradation, immortalization, phylogeny, and epidemiologic risk classification. Cancer Epidemiol Biomarkers Prev 2006; 15: 1262-7.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1262-1267
    • Hiller, T.1    Poppelreuther, S.2    Stubenrauch, F.3
  • 64
    • 0037224988 scopus 로고    scopus 로고
    • Evaluation of p53 and Bcl-2 expression as prognostic markers in invasive cervical carcinoma stage IIb/III patients treated by radiotherapy
    • Jan
    • Jain D, Srinivasan R, Patel FD, Kumari Gupta S. Evaluation of p53 and Bcl-2 expression as prognostic markers in invasive cervical carcinoma stage IIb/III patients treated by radiotherapy. Gynecol Oncol 2003 Jan; 88: 22-8.
    • (2003) Gynecol Oncol , vol.88 , pp. 22-28
    • Jain, D.1    Srinivasan, R.2    Patel, F.D.3    Kumari Gupta, S.4
  • 65
    • 0034766624 scopus 로고    scopus 로고
    • p53 and p21 expression in precancerous lesions and carcinomas of the uterine cervix: Overexpression of p53 predicts poor disease outcome
    • Huang LW, Chou YY, Chao SL, Chen TJ, Lee TT. p53 and p21 expression in precancerous lesions and carcinomas of the uterine cervix: overexpression of p53 predicts poor disease outcome. Gynecol Oncol 2001; 83: 348-54.
    • (2001) Gynecol Oncol , vol.83 , pp. 348-354
    • Huang, L.W.1    Chou, Y.Y.2    Chao, S.L.3    Chen, T.J.4    Lee, T.T.5
  • 68
    • 0030298333 scopus 로고    scopus 로고
    • Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation therapy alone
    • Ebara T, Mitsuhashi N, Saito Y, et al. Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation therapy alone. Gynecol Oncol 1996; 63: 216-8.
    • (1996) Gynecol Oncol , vol.63 , pp. 216-218
    • Ebara, T.1    Mitsuhashi, N.2    Saito, Y.3
  • 69
    • 0033812996 scopus 로고    scopus 로고
    • Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix
    • Giarnieri E, Mancini R, Pisani T, et al. Msh2, Mlh1, Fhit, p53, Bcl-2, and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix. Clin Cancer Res 2000; 6: 3600-6.
    • (2000) Clin Cancer Res , vol.6 , pp. 3600-3606
    • Giarnieri, E.1    Mancini, R.2    Pisani, T.3
  • 70
    • 0031282222 scopus 로고    scopus 로고
    • Loss of heterozygosity of the retinoblastoma and p53 genes in primary cervical carcinomas with human papillomavirus infection
    • Kim JW, Lee CG, Han SM, et al. Loss of heterozygosity of the retinoblastoma and p53 genes in primary cervical carcinomas with human papillomavirus infection. Gynecol Oncol 1997; 67: 215-21.
    • (1997) Gynecol Oncol , vol.67 , pp. 215-221
    • Kim, J.W.1    Lee, C.G.2    Han, S.M.3
  • 71
    • 0029937224 scopus 로고    scopus 로고
    • p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesions
    • Kurvinen K, Syrjänen K, Syrjänen S. p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesions. J Clin Oncol 1996; 14: 2120-30.
    • (1996) J Clin Oncol , vol.14 , pp. 2120-2130
    • Kurvinen, K.1    Syrjänen, K.2    Syrjänen, S.3
  • 72
    • 0034666277 scopus 로고    scopus 로고
    • Differential expression of p53 and p21 in low grade cervical squamous intraepithelial lesions infected with low, intermediate, and high risk human papillomaviruses
    • Giannoudis A, Herrington CS. Differential expression of p53 and p21 in low grade cervical squamous intraepithelial lesions infected with low, intermediate, and high risk human papillomaviruses. Cancer 2000; 89: 1300-7.
    • (2000) Cancer , vol.89 , pp. 1300-1307
    • Giannoudis, A.1    Herrington, C.S.2
  • 73
    • 57149085039 scopus 로고    scopus 로고
    • Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis
    • Zehbe I, Richard C, DeCarlo CA, et al. Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis. Virology 2009; 383: 69-77.
    • (2009) Virology , vol.383 , pp. 69-77
    • Zehbe, I.1    Richard, C.2    DeCarlo, C.A.3
  • 74
    • 7144250518 scopus 로고    scopus 로고
    • Role of a p53 polymorphism in the development of human papillomavirus-associated cancer
    • Storey A, Thomas M, Kalita A, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998; 393: 229-34.
    • (1998) Nature , vol.393 , pp. 229-234
    • Storey, A.1    Thomas, M.2    Kalita, A.3
  • 75
    • 78650244168 scopus 로고    scopus 로고
    • Germline polymorphisms of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis
    • Ueda M, Toji E, Nunobiki O, et al. Germline polymorphisms of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis. Hum Cell 2010; 23: 119-25.
    • (2010) Hum Cell , vol.23 , pp. 119-125
    • Ueda, M.1    Toji, E.2    Nunobiki, O.3
  • 76
    • 77949725819 scopus 로고    scopus 로고
    • TP53, MDM2, NQO1, and susceptibility to cervical cancer
    • Hu X, Zhang Z, Ma D, et al. TP53, MDM2, NQO1, and susceptibility to cervical cancer. Cancer Epidemiol Biomarkers Prev 2010; 19: 755-61.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 755-761
    • Hu, X.1    Zhang, Z.2    Ma, D.3
  • 77
    • 33748462072 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervix
    • Sarian LO, Derchain SF, Yoshida A, Vassallo J, Pignataro F, De Angelo Andrade LA. Expression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervix. Gynecol Oncol 2006; 102: 537-41.
    • (2006) Gynecol Oncol , vol.102 , pp. 537-541
    • Sarian, L.O.1    Derchain, S.F.2    Yoshida, A.3    Vassallo, J.4    Pignataro, F.5    de Angelo Andrade, L.A.6
  • 78
    • 16244415576 scopus 로고    scopus 로고
    • Differentiating highgrade cervical intraepithelial lesion from atrophy in postmenopausal women using Ki-67, cyclin E, and p16 immunohistochemical analysis
    • Qiao X, Bhuiya TA, Spitzer M. Differentiating highgrade cervical intraepithelial lesion from atrophy in postmenopausal women using Ki-67, cyclin E, and p16 immunohistochemical analysis. J Low Genit Tract Dis 2005; 9: 100-107.
    • (2005) J Low Genit Tract Dis , vol.9 , pp. 100-107
    • Qiao, X.1    Bhuiya, T.A.2    Spitzer, M.3
  • 79
    • 0024643202 scopus 로고
    • Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes
    • Verheijen R, Kuijpers HJ, van Driel R, et al. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes. J Cell Sci 1989; 92: 531-40.
    • (1989) J Cell Sci , vol.92 , pp. 531-540
    • Verheijen, R.1    Kuijpers, H.J.2    van Driel, R.3
  • 80
    • 0030002363 scopus 로고    scopus 로고
    • Cyclin D1 gene expression in human cervical neoplasia
    • Nichols GE, Williams ME, Gaffey MJ, et al. Cyclin D1 gene expression in human cervical neoplasia. Mod Pathol 1996; 9: 418-425.
    • (1996) Mod Pathol , vol.9 , pp. 418-425
    • Nichols, G.E.1    Williams, M.E.2    Gaffey, M.J.3
  • 81
    • 0035954134 scopus 로고    scopus 로고
    • Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix
    • Cheung TH, Yu MM, Lo KW, et al. Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. Cancer Lett 2001; 166: 199-206.
    • (2001) Cancer Lett , vol.166 , pp. 199-206
    • Cheung, T.H.1    Yu, M.M.2    Lo, K.W.3
  • 82
    • 0034991403 scopus 로고    scopus 로고
    • Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus
    • Bae DS, Cho SB, Kim YJ, et al. Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus. Gynecol Oncol 2001; 81: 341-7.
    • (2001) Gynecol Oncol , vol.81 , pp. 341-347
    • Bae, D.S.1    Cho, S.B.2    Kim, Y.J.3
  • 83
    • 38949096774 scopus 로고    scopus 로고
    • Alterations found in pl6/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium
    • Vijayalakshmi N, Selvaluxmi G, Majhi U, et al. Alterations found in pl6/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium. Oncol Res 2007; 16: 527-533.
    • (2007) Oncol Res , vol.16 , pp. 527-533
    • Vijayalakshmi, N.1    Selvaluxmi, G.2    Majhi, U.3
  • 84
    • 84861008585 scopus 로고    scopus 로고
    • Analysis of performance characteristics of five cell cycle-related immunohistochemical markers and human papillomavirus genotyping in the diagnosis of cervical squamous cell carcinoma precursor lesions
    • Conesa-Zamora P, Trujillo-Santos J, Orantes-Casado FJ, Ortiz-Reina S, Pérez-Guillermo M. Analysis of performance characteristics of five cell cycle-related immunohistochemical markers and human papillomavirus genotyping in the diagnosis of cervical squamous cell carcinoma precursor lesions. Anal Quant Cytol Histol 2012; 34: 49-55.
    • (2012) Anal Quant Cytol Histol , vol.34 , pp. 49-55
    • Conesa-Zamora, P.1    Trujillo-Santos, J.2    Orantes-Casado, F.J.3    Ortiz-Reina, S.4    Pérez-Guillermo, M.5
  • 85
    • 34247543060 scopus 로고    scopus 로고
    • A study of Ki-67, cerbB2 and cyclin D-1 expression in CIN-I, CIN-III and squamous cell carcinoma of the cervix
    • Carreras R, Alameda F, Mancebo G, et al. A study of Ki-67, cerbB2 and cyclin D-1 expression in CIN-I, CIN-III and squamous cell carcinoma of the cervix. Histol Histopathol 2007; 22: 587-592.
    • (2007) Histol Histopathol , vol.22 , pp. 587-592
    • Carreras, R.1    Alameda, F.2    Mancebo, G.3
  • 86
    • 0027154638 scopus 로고
    • Cyclin D1 is a nuclear protein required for cell cycle progression in G1
    • Baldin V, Lukas J, Marcote MJ, et al. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993; 7: 812-821.
    • (1993) Genes Dev , vol.7 , pp. 812-821
    • Baldin, V.1    Lukas, J.2    Marcote, M.J.3
  • 87
    • 33746461747 scopus 로고    scopus 로고
    • Cell cycle regulators p105, p107, Rb2/p130, E2F4, p21CIP1/WAF1, cyclin A in predicting cervical intraepithelial neoplasia, high-risk human papillomavirus infections and their outcome in women screened in three new independent states of the former Soviet Union
    • Santopietro R, Shabalova I, Petrovichev N, et al. Cell cycle regulators p105, p107, Rb2/p130, E2F4, p21CIP1/WAF1, cyclin A in predicting cervical intraepithelial neoplasia, high-risk human papillomavirus infections and their outcome in women screened in three new independent states of the former Soviet Union. Cancer Epidemiol Biomarkers Prev 2006; 15: 1250-6.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1250-1256
    • Santopietro, R.1    Shabalova, I.2    Petrovichev, N.3
  • 88
    • 0032527918 scopus 로고    scopus 로고
    • Differential cell cycle regulation by low-and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix
    • Southern SA, Herrington CS. Differential cell cycle regulation by low-and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix. Cancer Res 1998; 58: 2941-5.
    • (1998) Cancer Res , vol.58 , pp. 2941-2945
    • Southern, S.A.1    Herrington, C.S.2
  • 89
    • 0035935256 scopus 로고    scopus 로고
    • Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma
    • Cheung TH, Lo KW, Yu MM, et al. Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma. Cancer Lett 2001; 172: 93-8.
    • (2001) Cancer Lett , vol.172 , pp. 93-98
    • Cheung, T.H.1    Lo, K.W.2    Yu, M.M.3
  • 91
    • 79957472045 scopus 로고    scopus 로고
    • Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology
    • Petry KU, Schmidt D, Scherbring S, et al. Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology. Gynecol Oncol 2011; 121: 505-9.
    • (2011) Gynecol Oncol , vol.121 , pp. 505-509
    • Petry, K.U.1    Schmidt, D.2    Scherbring, S.3
  • 92
    • 79960289546 scopus 로고    scopus 로고
    • p16 immunocytochemistry on cell blocks as an adjunct to cervical cytology: Potential reflex testing on specially prepared cell blocks from residual liquid-based cytology specimens
    • Shidham VB, Mehrotra R, Varsegi G, D'Amore KL, Hunt B, Narayan R. p16 immunocytochemistry on cell blocks as an adjunct to cervical cytology: Potential reflex testing on specially prepared cell blocks from residual liquid-based cytology specimens. Cytojournal 2011; 8: 1.
    • (2011) Cytojournal , vol.8 , pp. 1
    • Shidham, V.B.1    Mehrotra, R.2    Varsegi, G.3    D'Amore, K.L.4    Hunt, B.5    Narayan, R.6
  • 93
    • 85047696240 scopus 로고    scopus 로고
    • Automated Detection of Dual p16/Ki67 Nuclear Immunoreactivity in Liquid-Based Pap Tests for Improved Cervical Cancer Risk Stratification
    • Jan 4. [in press]
    • Gertych A, Joseph AO, Walts AE, Bose S. Automated Detection of Dual p16/Ki67 Nuclear Immunoreactivity in Liquid-Based Pap Tests for Improved Cervical Cancer Risk Stratification. Ann Biomed Eng. 2012 Jan 4. [in press]
    • (2012) Ann Biomed Eng.
    • Gertych, A.1    Joseph, A.O.2    Walts, A.E.3    Bose, S.4
  • 94
    • 0037446976 scopus 로고    scopus 로고
    • Identification of cervical cancer markers by cDNA and tissue microarrays
    • Chen Y, Miller C, Mosher R, et al. Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res 2003; 63: 1927-35.
    • (2003) Cancer Res , vol.63 , pp. 1927-1935
    • Chen, Y.1    Miller, C.2    Mosher, R.3
  • 95
    • 19944427466 scopus 로고    scopus 로고
    • Gene expression profiles of primary HPV16-and HPV18-infected early stage cervical cancers and normal cervical epithelium: Identification of novel candidate molecular markers for cervical cancer diagnosis and therapy
    • Santin AD, Zhan F, Bignotti E, et al. Gene expression profiles of primary HPV16-and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 2005; 331: 269-91.
    • (2005) Virology , vol.331 , pp. 269-291
    • Santin, A.D.1    Zhan, F.2    Bignotti, E.3
  • 96
    • 0031037098 scopus 로고    scopus 로고
    • Mechanisms restricting DNA replication to once per cell cycle: The role of Cdc6p and ORC
    • Romanowski P, Madine MA. Mechanisms restricting DNA replication to once per cell cycle: the role of Cdc6p and ORC. Trends Cell Biol 1997; 7: 9-10.
    • (1997) Trends Cell Biol , vol.7 , pp. 9-10
    • Romanowski, P.1    Madine, M.A.2
  • 97
    • 61449145548 scopus 로고    scopus 로고
    • Immunohistochemical evaluation of ProEx C in human papillomavirusinduced lesions of the cervix
    • Conesa-Zamora P, Doménech-Peris A, Ortiz-Reina S, et al. Immunohistochemical evaluation of ProEx C in human papillomavirusinduced lesions of the cervix. J Clin Pathol 2009; 62: 159-62.
    • (2009) J Clin Pathol , vol.62 , pp. 159-162
    • Conesa-Zamora, P.1    Doménech-Peris, A.2    Ortiz-Reina, S.3
  • 98
    • 34547850211 scopus 로고    scopus 로고
    • Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions
    • Shi J, Liu H, Wilkerson M, et al. Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions. Hum Pathol 2007; 38: 1335-44.
    • (2007) Hum Pathol , vol.38 , pp. 1335-1344
    • Shi, J.1    Liu, H.2    Wilkerson, M.3
  • 99
    • 46249119192 scopus 로고    scopus 로고
    • BD ProEx C: A sensitive and specific marker of HPV-associated squamous lesions of the cervix
    • Badr RE, Walts AE, Chung F, et al. BD ProEx C: a sensitive and specific marker of HPV-associated squamous lesions of the cervix. Am J Surg Pathol 2008; 32: 899-906.
    • (2008) Am J Surg Pathol , vol.32 , pp. 899-906
    • Badr, R.E.1    Walts, A.E.2    Chung, F.3
  • 100
    • 50249171666 scopus 로고    scopus 로고
    • Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics
    • Pinto AP, Schlecht NF, Woo TY, et al. Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics. Mod Pathol 2008; 21: 1067-74.
    • (2008) Mod Pathol , vol.21 , pp. 1067-1074
    • Pinto, A.P.1    Schlecht, N.F.2    Woo, T.Y.3
  • 101
    • 47049112761 scopus 로고    scopus 로고
    • Quantitative detection of molecular markers ProEx C (minichromosome maintenance protein 2 and topoisomerase IIa) and MIB-1 in liquidbased cervical squamous cell cytology
    • Beccati MD, Buriani C, Pedriali M, Rossi S, Nenci I. Quantitative detection of molecular markers ProEx C (minichromosome maintenance protein 2 and topoisomerase IIa) and MIB-1 in liquidbased cervical squamous cell cytology. Cancer 2008; 114: 196-203.
    • (2008) Cancer , vol.114 , pp. 196-203
    • Beccati, M.D.1    Buriani, C.2    Pedriali, M.3    Rossi, S.4    Nenci, I.5
  • 102
    • 33750085559 scopus 로고    scopus 로고
    • Validation of a novel immunocytochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression in cervical cytology
    • Shroyer KR, Homer P, Heinz D, Singh M. Validation of a novel immunocytochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression in cervical cytology. Cancer 2006; 108: 324-30.
    • (2006) Cancer , vol.108 , pp. 324-330
    • Shroyer, K.R.1    Homer, P.2    Heinz, D.3    Singh, M.4
  • 103
    • 33846148030 scopus 로고    scopus 로고
    • Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C)
    • Kelly D, Kincaid E, Fansler Z, Rosenthal DL, Clark DP. Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C). Cancer 2006; 108: 494-500.
    • (2006) Cancer , vol.108 , pp. 494-500
    • Kelly, D.1    Kincaid, E.2    Fansler, Z.3    Rosenthal, D.L.4    Clark, D.P.5
  • 104
    • 55249112008 scopus 로고    scopus 로고
    • Detecting high-grade cervical disease on ASC-H cytology: Role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing
    • Siddiqui MT, Cohen C, Nassar A. Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing. Am J Clin Pathol 2008; 130: 765-70.
    • (2008) Am J Clin Pathol , vol.130 , pp. 765-770
    • Siddiqui, M.T.1    Cohen, C.2    Nassar, A.3
  • 105
    • 54449088432 scopus 로고    scopus 로고
    • ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: Correlation study with histologic biopsy
    • Siddiqui MT, Hornaman K, Cohen C, Nassar A. ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsy. Arch Pathol Lab Med 2008; 132: 1648-52.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 1648-1652
    • Siddiqui, M.T.1    Hornaman, K.2    Cohen, C.3    Nassar, A.4
  • 107
    • 0032772122 scopus 로고    scopus 로고
    • Minichromosome maintenance proteins as biological markers of dysplasia and malignancy
    • Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999; 5: 2121-32.
    • (1999) Clin Cancer Res , vol.5 , pp. 2121-2132
    • Freeman, A.1    Morris, L.S.2    Mills, A.D.3
  • 109
    • 76149114613 scopus 로고    scopus 로고
    • Role of ProExC: A novel immunoperoxidase marker in the evaluation of dysplastic squamous and glandular lesions in cervical specimens
    • Sanati S, Huettner P, Ylagan LR. Role of ProExC: a novel immunoperoxidase marker in the evaluation of dysplastic squamous and glandular lesions in cervical specimens. Int J Gynecol Pathol 2010; 29: 79-87.
    • (2010) Int J Gynecol Pathol , vol.29 , pp. 79-87
    • Sanati, S.1    Huettner, P.2    Ylagan, L.R.3
  • 110
    • 68949221640 scopus 로고    scopus 로고
    • A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics
    • Aximu D, Azad A, Ni R, Colgan T, Nanji S. A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. Int J Gynecol Pathol 2009; 28: 114-9.
    • (2009) Int J Gynecol Pathol , vol.28 , pp. 114-119
    • Aximu, D.1    Azad, A.2    Ni, R.3    Colgan, T.4    Nanji, S.5
  • 111
    • 59849099914 scopus 로고    scopus 로고
    • Comparison of ProEx C with p16INK4a and Ki-67 immunohistochemical staining of cell blocks prepared from residual liquidbased cervicovaginal material: A pilot study
    • Halloush RA, Akpolat I, Jim Zhai Q, Schwartz MR, Mody DR. Comparison of ProEx C with p16INK4a and Ki-67 immunohistochemical staining of cell blocks prepared from residual liquidbased cervicovaginal material: a pilot study. Cancer 2008; 114: 474-80.
    • (2008) Cancer , vol.114 , pp. 474-480
    • Halloush, R.A.1    Akpolat, I.2    Jim Zhai, Q.3    Schwartz, M.R.4    Mody, D.R.5
  • 112
    • 79959345833 scopus 로고    scopus 로고
    • Biomarker expression in cervical intraepithelial neoplasia: Potential progression predictive factors for low-grade lesions
    • Ozaki S, Zen Y, Inoue M. Biomarker expression in cervical intraepithelial neoplasia: potential progression predictive factors for low-grade lesions. Hum Pathol 2011; 42: 1007-12.
    • (2011) Hum Pathol , vol.42 , pp. 1007-1012
    • Ozaki, S.1    Zen, Y.2    Inoue, M.3
  • 113
    • 67349113948 scopus 로고    scopus 로고
    • p16, Ki-67, and BD ProExC immunostaining: A practical approach for diagnosis of cervical intraepithelial neoplasia
    • Walts AE, Bose S. p16, Ki-67, and BD ProExC immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia. Hum Pathol 2009; 40: 957-64.
    • (2009) Hum Pathol , vol.40 , pp. 957-964
    • Walts, A.E.1    Bose, S.2
  • 114
    • 84855309413 scopus 로고    scopus 로고
    • Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    • Wheeler CM, Castellsagué X, Garland SM, et al. Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial. Lancet Oncol 2012; 13: 100-10.
    • (2012) Lancet Oncol , vol.13 , pp. 100-110
    • Wheeler, C.M.1    Castellsagué, X.2    Garland, S.M.3
  • 115
    • 84855169688 scopus 로고    scopus 로고
    • Comparison of the immunogenicity of the human papillomavirus (HPV)-16/18 vaccine and the HPV-6/11/16/18 vaccine for oncogenic non-vaccine types HPV-31 and HPV-45 in healthy women aged 18-45 years
    • Einstein MH, Baron M, Levin MJ, et al. Comparison of the immunogenicity of the human papillomavirus (HPV)-16/18 vaccine and the HPV-6/11/16/18 vaccine for oncogenic non-vaccine types HPV-31 and HPV-45 in healthy women aged 18-45 years. Hum Vaccin 2011; 7: 1359-73
    • (2011) Hum Vaccin , vol.7 , pp. 1359-1373
    • Einstein, M.H.1    Baron, M.2    Levin, M.J.3


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