Atypical immature cervical metaplasia: immunoprofiling and longitudinal outcome

Human Pathology

Volumn 37, Issue 11, 2006, Pages 1473-1481

  Duggan, Máire A ^a   Akbari, Majid ^c   Magliocco, Anthony M ^a,b  

^a Laboratory Medicine   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Atypical immature metaplasia; Immunoprofiling; Ki 67; Outcome; p16

Indexed keywords

KI 67 ANTIGEN; PROTEIN P16;

ADOLESCENT; ADULT; AGED; ARTICLE; ATYPICAL IMMATURE CERVICAL METAPLASIA; CANCER DIAGNOSIS; CANCER GRADING; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PREDICTION; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA IN SITU; UTERUS TUMOR;

CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; METAPLASIA; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 33750051084     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2006.05.013     Document Type: Article

References (19)

1. Wright T.C., Kurman R.J., and Ferenczy A. Precancerous lesions of the cervix. In: Kurman R.J. (Ed). Blaustein's pathology of the female genital tract. 5th ed. (2002), Springer, New York (USA) 253-324
2. Cattoretti G., Becker M.H., Key G., et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detects proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168 (1992) 357-363
3. Keating J.T., Ince T., and Crum C.P. Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv Anat Pathol 8 (2001) 83-92
4. INK4a expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 16 (2003) 665-673
5. Stoler M.H. Human papillomaviruses and cervical neoplasia. A model for carcinogenesis. Int J Gynecol Pathol 19 (2000) 16-28
6. Khleif S.N., DeGregori J., Yee C.L., et al. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A 93 (1996) 4350-4354
7. Park J.J., Genest D.R., Sun D., and Crum C.P. Atypical immature metaplastic-like proliferations of the cervix: diagnostic reproducibility and viral (HPV) correlates. Hum Pathol 30 (1999) 1161-1165
8. Crum C.P., Egawa K., Fu Y.S., et al. Atypical immature metaplasia (AIM). A subset of human papilloma virus infection of the cervix. Cancer 51 (1983) 2214-2219
9. Geng L., Connolly D.C., Isacson C., Ronnett B.M., and Cho K.R. Atypical immature metaplasia (AIM) of the cervix: is it related to high-grade squamous intraepithelial lesion (HSIL)?. Hum Pathol 30 (1999) 345-351
10. INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol 25 (2001) 884-891
11. Kurman R.J., Norris H.J., and Wilkinson E. Tumors of the cervix, vagina and vulva. Atlas of tumor pathology (1992), Armed Forces Institute of Pathology, Washington (DC, USA) 40-42
12. Ward B.E., Saleh A.M., Williams J.V., and Crum C.P. Atypical immature metaplasia of the cervix: a reevaluation. Lab Invest 64 (1991) 62A
13. Boenisch T. Handbook immunohistochemical staining methods (2001), Dako, Carpinteria (CA)
14. Stoler M.H., and Schiffman M. Atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS) group. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates form the ASCUS-LSIL Triage Study. JAMA 285 (2001) 1500-1505
15. Sherman M.E., Abdul-Karim F.W., Berek J.S., Powers C.N., Sidawy K., and Tabbara S.O. Atypical squamous cells. In: Solomon D., and Nayer R. (Eds). The Bethesda system for reporting cervical cytology. 2nd ed. (2004), Springer, New York (USA) 67-87
16. INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26 (2002) 1389-1399
17. Solomon D., and Castle P.E. Findings from ALTS. Impact on cervical screening, triage, and patient management. PCR 3 (2005) 128-137
18. Duggan M.A., McGregor S.E., Stuart G.C.E., et al. The natural history of CIN 1. Eur J Gynaecol Oncol 19 (1998) 338-344
19. Cox J.T. Management of women with cervical cancer precursor lesions. Obstet Gynecol Clin North Am 29 (2002) 787-816