Alterations found in p16/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium

Oncology Research

Volumn 16, Issue 11, 2007, Pages 527-533

  Vijayalakshmi, N ^a   Selvaluxmi, G ^a   Majhi, U ^a   Rajkumar, T ^a  

^a CANCER INSTITUTE WIA   (India)

Author keywords

Cervical cancer; Cyclin D1; Cyclin D1 p16 Rb pathway; HPV; p16; Retinoblastoma protein (pRb)

Indexed keywords

BIOLOGICAL MARKER; CYCLIN D1; PROTEIN P16; RETINOBLASTOMA PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ARTICLE; CANCER INVASION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; UTERINE CERVIX CANCER; UTERINE CERVIX DYSPLASIA; UTERINE CERVIX EPITHELIUM; CANCER STAGING; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; INDIA; METABOLISM; PATHOLOGY; UTERINE CERVIX; UTERINE CERVIX TUMOR;

CERVIX UTERI; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOWN-REGULATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INDIA; NEOPLASM STAGING; PHENOTYPE; RETINOBLASTOMA PROTEIN; UTERINE CERVICAL DYSPLASIA; UTERINE CERVICAL NEOPLASMS;

EID: 38949096774     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504007783438367     Document Type: Article

References (29)

1. Bosch, F. X.; deSanjose, S. The epidemiology of human papillomavirus infection and cervical cancer. Dis. Markers 23(4):213-227; 2007.
2. Soni, S.; Kaur, J.; Chakravarthi, N.; Mathur, M.; Bahadur, S.; Shukla, N. K.; Deo, S. V.; Ralhan, R. Deregulation of p16/Rb/cyclin D1 pathway is an early event in oral tumorigenesis. Oncology 68:314-325; 2005.
3. Semczuk, A.; Miturski, R.; Skomra, D.; Jakowicki, J. A. Expression of cell cycle regulatory proteins (pRb, cyclin D1, p16 INK4 and CDK4) in human endometrial cancer: correlation with clinicopathological features. Arch. Gynecol. Obstet. 269:104-110; 2004.
4. Otterson, G. A.; Kratzke, R. A.; Coxon, A.; Kim, Y. W.; Kaye, F. J. Absence of p16INK4 protein is restricted to the subset of lung cancer cell lines that retains wild type Rb. Oncogene 9:3375-3378; 1994.
5. Kinoshita, I.; Dosaka-Akita, H.; Mishina, T.; Akie, K.; Nishi, M.; Hiroumi, H.; Hommura, F.; Kawakami, Y. Altered p16INK4 and retinoblastoma protein status in non small cell lung cancer: Potential synergistic effect with p53 protein on proliferative activity. Cancer Res. 56: 5557-5562; 1996.
6. Maelandmo, G. M.; Florenes, V. A.; Hovig, E.; Oyjord, T.; Engebraaten, O.; Holm, R.; Borresen, A. L.; Fodstad, O. Involvement of pRb/p16/CDK4/cyclin D pathway in the tumourigenesis of sporadic malignant melanomas. Br. J. Cancer 73:909-916; 1996.
7. Sambrook, J.; Fritsch, E. F.; Maniatis, T. Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
8. Chinchang, W.; Viprakasit, V.; Pung-Amritt, P.; Tanphaichitr, V. S.; Yenchitromanus, P. T. Molecular analysis of unknown β-globin gene mutations using PCR-SSCP and its application in Thai families with β thalassemias and β-globin variants. Clin. Biochem. 38:987-996; 2005.
9. Jacobs, M. V.; de Roda Husman, A. M.; VandenBrule, A. J.; Sniders, P. J.; Meijer, C. J.; Walboomers, J. M. Group specific differentiation between high and low risk HPV genotypes by general primer mediated PCR and two cocktails of oligonucleotide probes. J. Clin. Microbiol. 33: 901-905; 1995.
10. Rajkumar, T.; Sharmila, R.; Majhi, U.; Selvaluxmi, G.; Vasanthan, A.; Shanta, V. Bcl-2 and p53 expression in stage IIB and IIIB cervical cancers. Eur. J. Gynecol. Oncol. 19:556-560; 1998.
11. Nichols, G. E.; Williams, M.; Gaffey, M. J.; Stoler, M. H. Cyclin D1 gene expression in human cervical neoplasia. Mod. Pathol. 9:418-425; 1996.
12. Klaes, R.; Friedrich, T.; Spitkovsky, D.; Ridder, R.; Rudy, W.; Petry, U.; Dallenbach-Hellweg, G.; Schmidt, D.; von Knebel Doeberitz, M. Overexpression of p16 (INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix. Int. J. Cancer 92:276-284; 2001.
13. Cordon-Cardo, C.; Wartinger, D.; Petrylak, D.; Dalbagni, G.; Fair, W. R.; Fuks, Z.; Reuter, V. E. Altered expression of the retinoblastoma gene product prognostic indicator in bladder cancer. J. Natl. Cancer Inst. 84:1251-1256; 1992.
14. Fransceshi, S.; Rajkumar, T.; Vaccarella, S.; Gajalakshmi, V.; Sharmila, A.; Snijders, P. J.; Munoz, N.; Meijer, C. J.; Herrero, R. Human papillomavirus and risk factors for cervical cancer in Chennai, India - a case control study. Int. J. Cancer 107(1):127-133; 2003.
15. Peedicayil, A.; Abraham, P.; Sathish, N.; John, S.; Shah, K.; Sridharan, G.; Gravitt, P. Human papillomavirus genotypes associated with cervical neoplasia in India. Int. J. Gynecol. Cancer 16(4):1591-1595; 2006.
16. Rolfe, K. J.; Crow, J. C.; Benjamin, E.; Reid, W. M.; Maclean, A. B.; Perette, C. W. Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions. Int. J. Gynecol. Cancer 11(5):381-386; 2001.
17. Kusume, T.; Tsuda, H.; Kawabata, M.; Inoue, T.; Umasaki, N.; Suzuki, T.; Yamamato, K. The p16-cyclin D1/CDK4 pRb pathway and clinical outcome in epithelial ovarian cancer. Clin. Cancer Res. 5(12):4152-4157; 1999.
18. Lukas, J.; Muller, H.; Bartkova, J.; Spitkovsky, D.; Kjerulff, A.; Jansen-Dur, P.; Strauss, M.; Bartek, J. DNA tumour virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol. 125:625-638; 1994.
19. Khleif, S. N.; DeGregori, J.; Yee, C. L.; Otterson, G. A.; Kaye, F. J.; Nevins, J. R.; Howley, P. M. Inhibition of cyclin D-CDK4/CDK6 activity is associated with E2F mediated induction of cyclin kinase inhibitor activity. Proc. Natl. Acad. Sci. USA 93:4350-4354; 1996.
20. Xiong, Y.; Kuppuswamy, D.; Li, Y.; Livanos, E. M.; Hixon, M.; White, A.; Beach, D.; Tlsty, D. Alteration of cell cycle kinase complexes in human papilloma virus E6 and E7 expressing fibroblasts precedes neoplastic transformation. J. Virol. 70:999-1008; 1996.
21. Tsuda, H.; Hashiguchi, Y.; Nishimura, S.; Kawamura, N.; Inoue, T.; Yamamato, K. Relationship between HPV typing and abnormality of the G1 cell cycle regulators in cervical neoplasm. Gynecol. Oncol. 91:476-485; 2003.
22. Bahnassy, A. A.; Zekri, A. R.; Saleh, M.; Lotayef, M.; Moneir, M.; Shawki, O. Possible role of cell cycle regulators in multistep process of HPV associated cervical carcinoma. BMC Clin. Pathol. 7:4-9; 2007.
23. Nam, E. J.; Kim, J. W.; Kim, S. W.; Kim, Y. T.; Kim, J. H.; Yoon, B. S.; Cho, N. H.; Kim, S. The expressions of the Rb pathway in CIN, predictive and prognostic significance. Gynecol. Oncol. 104(1):207-211; 2007.
24. Koh, J.; Enders, G. H.; Dynlacht, B. D.; Harlow, E. Tumour-derived p16 alleles encoding proteins defective in cell cycle inhibition. Nature 375:506-510; 1995.
25. Lukas, J.; Parry, D.; Aagaard, L.; Mann, D. J.; Strauss, M.; Peters, G.; Bartek, J. Retinoblastoma protein dependent cell-cycle inhibition by tumour suppressor p16. Nature 375:503-506; 1995.
26. Serrano, M.; Gomez-Lahox, E.; DePinho, R. A.; Beach, D.; Bar-Sagi, D. Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science 267:249-252; 1995.
27. Medema, R. H.; Herrera, R. E.; Lam, F.; Weinberg, R. A. Growth suppression by p16 INK4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA 92:6289-6293; 1995.
28. Lukas, J.; Aagarrd, L.; Strauss, M.; Bartek, J. Oncogenic aberrations of p16 INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res. 55:4818-4823; 1995.
29. Shapiro, G. I.; Edwards, C. D.; Kobzik, L.; Godleski, J.; Richard, W.; Sugarbaker, D. J.; Rollins, B. J. Reciprocal RB inactivation and p16 INK4 expression in primary lung cancers and cell lines. Cancer Res. 55:505-509; 1995.