Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes

Cancer Research

Volumn 59, Issue 24, 1999, Pages 6132-6136

  Klaes, Ruediger ^a   Woerner, Stefan M ^a   Ridder, Ruediger ^a,c   Wentzensen, Nicolas ^a   Duerst, Matthias ^b   Schneider, Achim ^b   Lotz, Beatrix ^b   Melsheimer, Peter ^a   Von Knebel Doeberitz, Magnus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c MTM Laboratories AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GROWTH; EPISOME; GENE AMPLIFICATION; GENE SEQUENCE; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DNA CELL DNA INTERACTION; WART VIRUS;

BIOPSY; CERVICAL INTRAEPITHELIAL NEOPLASIA; DISEASE PROGRESSION; FEMALE; GENE AMPLIFICATION; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROVIRUSES; RECOMBINANT FUSION PROTEINS; RISK FACTORS; RNA, VIRAL; SEQUENCE ANALYSIS; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 0033572319     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Morrison, E. A., Ho, G. Y., Vermund, S. H., Goldberg, G. L., Kadish, A. S., Kelley, K. F., and Burk, R. D. Human papillomavirus infection and other risk factors for cervical neoplasia: a case-control study. Int. J. Cancer. 49: 6-13, 1991.
2. Walboomers, J. M., and Meijer, C. J. Do HPV-negative cervical carcinomas exist? J. Pathol., 181: 253-254, 1997.
3. zur Hausen, H. Papillomavirus infections - a major cause of human cancers. Biochim. Biophys. Acta, 1288: F55-F78, 1996.
4. Cuzick, J., Meijer, C. J., and Walboomers, J. M. Screening for cervical cancer. Lancet. 351: 1439-1440, 1998.
5. Manos, M. M., Kinney, W. K., Hurley, L. B., Sherman, M. E., Shieh-Ngai, J., Kurman, R. J., Ransley, J. E., Fetterman, B. J., Hartinger, J. S., McIntosh, K. M., Pawlick, G. F., and Hiatt, R. A. Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. J. Am. Med. Assoc., 281: 1605-1610, 1999.
6. Kjaer, S. K., van den Brule, A. J., Bock, J. E., Poll, P. A., Engholm, G., Sherman, M. E., Walboomers, J. M., and Meijer, C. J. Determinants for genital human papillomavirus (HPV) infection in 1000 randomly chosen young Danish women with normal Pap smear: are there different risk profiles for oncogenic and nononcogenic HPV types? Cancer Epidemiol. Biomark. Prev., 6: 799-805, 1997.
7. Ho, G. Y., Bierman, R., Beardsley, L., Chang, C. J., and Burk, R. D. Natural history of cervicovaginal papillomavirus infection in young women. N. Engl. J. Med., 338: 423-428, 1998.
8. Ostor, A. G. Natural history of cervical intraepithelial neoplasia: a critical review. Int. J. Gynecol. Pathol., 12: 186-192, 1993.
9. Lehn, H., Villa, L. L., Marziona, F., Hilgarth, M., Hillemans, H. G., and Sauer, G. Physical state and biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract. J. Gen. Virol., 69: 187-196, 1988.
10. Fukushima, M., Yamakawa, Y., Shimano, S., Hashimoto, M., Sawada, Y., and Fujinaga, K. The physical state of human papillomavirus 16 DNA in cervical carcinoma and cervical intraepithelial neoplasia. Cancer (Phila.), 66: 2155-2161, 1990.
11. Baker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gonda, M. A., and Howley, P. M. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol., 61: 962-971, 1987.
12. Couturier, J., Sastre-Garau, X., Schneider-Maunoury, S., Labib, A., and Orth, G. Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression. J. Virol. 65: 4534-4538, 1991.
13. Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., and zur Hausen, H. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (Lond.), 314: 111-114, 1985.
14. Durst, M., Kleinheinz, A., Hotz, M., and Gissman, L. The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours. J. Gen. Virol., 66: 1515-1522, 1985.
15. Schneider-Gadicke, A., and Schwarz, E. Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J., 5: 2285-2292, 1986.
16. Choo, K. B., Pan, C. C., and Han, S. H. Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames. Virology, 161: 259-261, 1987.
17. Di Luca, D., Pilotti, S., Stefanon, B., Rotola, A., Monini, P., Tognon, M., De Palo, G., Rilke, F., and Cassai, E. Human papillomavirus type 16 DNA in genital tumours: a pathological and molecular analysis. J. Gen. Virol., 67: 583-589, 1986.
18. von Knebel Doeberitz, M., Bauknecht, T., Bartsch, D., and zur Hausen, H. Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells. Proc. Natl. Acad. Sci. USA, 88: 1411-1415, 1991.
19. Jeon, S., and Lambert, P. F. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl. Acad. Sci. USA, 92: 1654-1658, 1995.
20. von Knebel Doeberitz, M., Oltersdorf, T., Schwarz, E., and Gissmann, L. Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res., 48: 3780-3786, 1988.
21. von Knebel Doeberitz, M., Rittmuller, C., Aengeneyndt, F., Jansen-Durr, P., and Spitkovsky, D. Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions. J. Virol., 68: 2811-2821, 1994.
22. Meyer, T., Arndt, R., Stockfleth, E., Flammann, H. T., Wolf, H., and Reischl, U. Strategy for typing human papillomaviruses by RFLP analysis of PCR products and subsequent hybridization with a generic probe. Biotechniques, 19: 632-639, 1995.
23. Frohman, M. A., Dush, M. K., and Martin, G. R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA, 85: 8998-9002, 1988.
24. Hsu, E. M., McNicol, P. J., Guijon, F. B., and Paraskevas, M. Quantification of HPV-16 E6-E7 transcription in cervical intraepithelial neoplasia by reverse transcriptase polymerase chain reaction. Int. J. Cancer. 55: 397-401, 1993.
25. von Knebel Doeberitz, M. Papillomaviruses in human disease: Part II. Molecular biology and immunology of papillomavirus infections and carcinogenesis. Eur. J. Med., 1: 485-491, 1992.
26. Sherman, L., Alloul, N., Golan, I., Durst, M., and Baram, A. Expression and splicing patterns of human papillomavirus type-16 mRNAs in pre-cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers. Int. J. Cancer. 50: 356-364, 1992.
27. Popescu, N. C., Amsbaugh, S. C., and DiPaolo, J. A. Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW756. J. Virol., 61: 1682-1685, 1987.
28. James, G. K., Kalousek, D. K., and Auersperg, N. Karyotypic analysis of two related cervical carcinoma cell lines that contain human papillomavirus type 18 DNA and express divergent differentiation. Cancer Genet. Cytogenet., 38: 53-60, 1989.
29. Jeon, S., Allen-Hoffmann, B. L., and Lambert, P. F. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J. Virol., 69: 2989-2997, 1995.
30. Daniel, B., Mukherjee, G., Seshadri, L., Vallikad, E., and Krishna, S. Changes in the physical state and expression of human papillomavirus type 16 in the progression of cervical intraepithelial neoplasia lesions analysed by PCR. J. Gen. Virol., 76: 2589-2593, 1995.
31. Cullen, A. P., Reid, R., Campion, M., and Lorincz, A. T. Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J. Virol., 65: 606-612, 1991.
32. Das, B. C., Sharma, J. K., Gopalakrishna, V., and Luthra, U. K. Analysis by polymerase chain reaction of the physical state of human papillomavirus type 16 DNA in cervical preneoplastic and neoplastic lesions. J. Gen. Virol., 73: 2327-2336, 1992.
33. Chen, C. M., Shyu, M. P., Au, L. C., Chu, H. W., Cheng, W. T., and Choo, K. B. Analysis of deletion of the integrated human papillomavirus 16 sequence in cervical cancer: a rapid multiplex polymerase chain reaction approach. J. Med. Virol., 44: 206-211, 1994.
34. Donaldson, Y. K., Arends, M. J., Duvall, E., and Bird, C. C. A PCR approach to discriminate between integrated and episomal HPV DNA in small clinical specimens. Mol. Cell. Probes, 7: 285-292, 1993.
35. Carmody, M. W., Jones, M., Tarraza, H., and Vary, C. P. Use ot the polymerase chain reaction to specifically amplify integrated HPV-16 DNA by virtue of its linkage to interspersed repetitive DNA. Mol. Cell. Probes. 10: 107-116, 1996.
36. Kristiansen, E., Jenkins, A., and Holm, R. Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix. J. Clin. Pathol., 47: 253-256, 1994.