The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma

BMC Clinical Pathology

Volumn 7, Issue , 2007, Pages

  Bahnassy, Abeer A ^a   Zekri, Abdel Rahman N ^b   Saleh, Maha ^a   Lotayef, Mohammad ^b   Moneir, Manar ^c   Shawki, Osama ^d  

^a NATIONAL CANCER INSTITUTE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Cairo University   (Egypt)

^d CAIRO UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN E; KI 67 ANTIGEN; PROTEIN MDM2; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; METHYLATION; MULTIVARIATE ANALYSIS; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR VOLUME; UNIVARIATE ANALYSIS; UTERINE CERVIX CARCINOMA; WART VIRUS;

EID: 34250836496     PISSN: 14726890     EISSN: 14726890     Source Type: Journal    
DOI: 10.1186/1472-6890-7-4     Document Type: Article

References (30)

1. Detection of high risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. R Klaes SM Woerner R Ridder N Wentzensen M Duerst A Schneider B Lotz P Melsheimer M Von Knebel Doeberitz, Cancer res 1999 59 6132 9616 10626803
2. Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix. B Clarke R Chetty, Gynecol Oncol 2001 82 2 238 246 10.1006/gyno.2001.6306 11531273
3. Oncoproteins encoded by the cancer-associated papillomavirus target the products of retinoblastoma and p53 tumor suppressor genes. PM Howley M Scheffner K Munger, Quant Biol 1991 56 149 155
4. p16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. T Masumoto T Fuji M Ishikawa M Saito T Iwata T Fukuchi N Susumu M Mukai K Kubushiro K Tsukazaki S Nozawa, Hum Pathol 2003 34 778 783 10.1016/S0046-8177(03)00284-3 14506638
5. P53-independent growth regulation of cervical cancer cells by the papillomvirus E6 oncogene. D Spitokovsky F Aengeneyndt J Braspenning VK Doeberitz, Ocogene 1996 13 1027 1035
6. Differential expression of p53 and p21 in low grade cervical squamous intraepithelial lesions infected with low, intermediate, and high risk human papillomavirus. A Giannoudis CS Herrington, Cancer 2000 89 6 1300 1307 10.1002/1097-0142(20000915)89:6<1300::AID-CNCR15>3.0.CO;2-U 11002226
7. The role of human papilloma virus in the molecular biology of cervical varcinogenesis. S Motoyama CA Ladines-llave SL Villaneueva T Maruo, Kobe J Med Sci 2004 50 1 9 19 15342967
8. Aberrant expression of the cell cycle associated proteins TP53, MDM-2, P21, P27, cdK4, cyclin D1, RB, and EGFR in cervical carcinomas. H Skomedal GB Kristensen AK Lie R Holm, Gynecol Oncolo 1999 73 2 223 228 10.1006/gyno.1999. 5346
9. Cyclin E expression, a potential prognostic marker for non-small cell lung cancer. T Mishina H Dosaka-Akita F Hommura, Clin Cancer Res 2000 6 11 16 10656426
10. Pathology and Genetics. Tumors of the breast and female genital organs. World Health Organization Classification of Tumor, IARC Press Lyon, Tavassoli FA, Devilee P, 260 289
11. Molecular Cloning: A Laboratory Manual. J Sambrook EF Fritsch T Maniatis, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press 2 1989 9.16 9.23
12. Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes. MV Jacobs AM de Roda Husman AJ van den Brule PJ Snijders CJ Meijer JM Walboomers, J Clin Microbiol 1995 33 901 905 7790457
13. Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus. Y-L Zhai T Nikaido T Shiozawa A Orii S Fujii, Int J Cancer (Pred Oncol) 1999 84 3 244 250 10.1002/(SICI)1097-0215(19990621)84:3<244:: AID-IJC8>3.0.CO;2-2
14. waf, mdm-2, C-erbB2 and impact on survival. A Bahnassy ARN Zekri A El-Shehaby S Abdallah GM Sherif, Path Int 2005 55L 53 62 10.1111/j.1440-1827.2005.01804.x
15. Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix. TH Cheung MM Yu KW Lo SF Yim TK Chung YF Wong, Cancer Lett 2001 166 2 199 206 10.1016/S0304-3835(01)00457-8 11311493
16. INK4a genes in primary central nervous system lymphomas. M Nakamura T Sakaki H Hashimoto H Nakase E Ishida K Shimada N Konishi, Cancer Res 2001 61 17 6335 6339 11522621
17. Alterations of the P16 gene in uterine cervical carcinoma from Indian patients. A Tripathi S Banerjee A Roy S Roychowdhury CK Panda, Int J Gynecol Cancer 2003 13 4 472 9 10.1046/j.1525-1438.2003.13330.x 12911724
18. Secondary malignant giant cell tumor of bone: molecular abnormalities of p53 and H-ras gene correlated with malignant transformation. Y Oda A Sakamoto T Saito S Matsuda K Tanaka Y Iwamoto M Tsuneyoshi, Histopathology 2001 39 629 637 10.1046/j.1365-2559.2001.01275.x 11903582
19. Cyclin D1 gene expression in human cervical neoplasia. GE Nichols ME Williams MJ Gaffey MH Stoler, Mod Pathol 1996 9 4 418 25 8729983
20. Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus. DS Bae SB Cho YJ Kim JD Whang SY Song CS Park DS Kim JH Lee, Gynecol Oncol 2001 81 3 341 7 10.1006/gyno.2001.6196 11371120
21. Association of p27Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms. A Dellas E Schultheiss MR Leivas H Moch J Torhorst, Anticancer Res 1998 18 6A 3991 8 9891436
22. Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells. G Volgareva L Zavalishina Y Andreeva G Frank E Krutikova D Golovina A Bliev D Spitkovsky V Ermilova F Kisseljov, BMC Cancer 2004 4 58 15339339 10.1186/1471-2407-4-58
23. Inactivation of the cdk inhibitor p27Kip1 by the human papillomavirus type 16 E7 oncoprotein. K Zerfass-Thome W Zwerschke B Mannhardt R Tindle JW Botz P Jansen-Durr, Ocogene 1996 13 11 2323 30
24. Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis. G Van de Putte R Holm AK Lie CG Trope GB Kristensen, Gynecol Oncol 2003 89 1 140 7 10.1016/S0090-8258(03)00010-6 12694668
25. Kip1 expression in normal and neoplastic cervical epithelia. G Troncone A Vetrani GD Rosa D Gerbasio L Palombini, J Clin Pathol 1999 52 880 7 10711250
26. Expression of cyclin E and p27(KIP1) in cervical carcinoma. Y Tae Kim E Kyoung Choi N Hoon Cho J Hung Ko W Ick Yang J Wook Kim S Ho Lee, Cancer Lett 2000 153 1-2 41 50 10.1016/S0304-3835(00)00345-1 10779628
27. Expression of the cell cycle regulator p27 (Kip1) in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix. Immunohistochemistry and functional aspects. T Shiozawa S Shiohara M Kanai I Konishi S Fujii T Nikaido, Cancer 2001 92 12 3005 3011 10.1002/1097-0142(20011215)92:12<3005::AID-CNCR10153>3.0.CO;2-6 11753978
28. Evaluation of p16INK4A and pRb expression in cervical squamous and glandular neoplasia. B Tringler CJ Gup M Singh S Groshong AL Shroyer DA Heinz KR Shroyer, Hum Pathol 2004 35 6 689 696 10.1016/j.humpath.2004.02.012 15188135
29. Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm. H Tsuda Y Hashiguchi S Nishimura N Kawamura T Inoue K Yamamoto, Gynecol Oncol 2003 91 3 476 85 10.1016/j.ygyno.2003.08.019 14675665
30. Down-regulation of p27 is associated with malignant transformation and aggressive phenotype of cervical neoplasms. LW Huang SL Chao JL Hwang YY Chou, Gynecol Oncol 2002 85 3 524 8 10.1006/gyno.2002.6666 12051885