Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIα, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions

Human Pathology

Volumn 38, Issue 9, 2007, Pages 1335-1344

  Shi, Jianhui ^a   Liu, Haiyan ^b   Wilkerson, Myra ^a   Huang, Yajue ^c   Meschter, Steven ^a   Dupree, William ^a   Schuerch, Conrad ^a   Lin, Fan ^a  

^a GEISINGER MEDICAL CENTER   (United States)

^b LEHIGH VALLEY HOSPITAL   (United States)

^c TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

Cervical biopsy; p16 ProEX C; p16INK4a; ProEX C; Squamous intraepithelial lesions

Indexed keywords

BIOCHEMICAL MARKER; CELL CYCLE PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN P16INK4A; PROTEIN PROEX C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA IN SITU;

ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 34547850211     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.01.025     Document Type: Article

References (33)

1. DeMay R.M. The Pap smear. In: DeMay R.M. (Ed). The art and science of cytopathology (1996), American Society of Clinical Pathologists Press, Chicago 61-205
2. Weir H.K., Thun M.J., Hankey B.F., et al. Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control. J Natl Cancer Inst 95 (2003) 1276-1299
3. Stoler M.H., and Schiffman M. Atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS) group. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates form the ASCUS-LSIL Triage Study. JAMA 285 (2001) 1500-1505
4. Schiffman M., Wheeler C.M., Dasgupta A., et al. A comparison of a prototype PCR assay and hybrid capture 2 for detection of carcinogenic human papillomavirus DNA in women with equivocal or mildly abnormal Papanicolaou smears. Am J Clin Pathol 124 (2005) 722-732
5. Centers for Disease Control and Prevention. Genital HPV infection-CDC fact sheet (2004), Centers for Disease Control and Prevention, Atlanta, GA
6. Agoff S.N., Dean T., Nixon B.K., et al. The efficacy of reprocessing unsatisfactory cervicovaginal ThinPrep specimens with and without glacial acetic acid: effect on Hybrid Capture II human papillomavirus testing and clinical follow-up. Am J Clin Pathol 118 (2002) 727-732
7. Malinowski D.P. Molecular diagnostic assays for cervical neoplasia: emerging markers for the detection of high-grade cervical disease. Biotechniques Suppl 4 (2005) 17-23
8. Ishimi Y., Okayasu I., Kato C., et al. Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix. Eur J Biochem 270 (2003) 1089-1101
9. Lorenzato M., Caudroy S., Bronner C., et al. Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?. Hum Pathol 36 (2005) 1101-1107
10. Santin A.D., Zhan F., Bignotti E., et al. Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 331 (2005) 269-291
11. Chen Y., Miller C., Mosher R., et al. Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res 63 (2003) 1927-1935
12. Holladay E.B., Logan S., Arnold J., et al. A comparison of the clinical utility of p16(INK4a) immunolocalization with the presence of human papillomavirus by hybrid capture 2 for the detection of cervical dysplasia/neoplasia. Cancer 108 (2006) 451-461
13. Ansari-Lari M.A., Staebler A., Zaino R.J., et al. Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol 28 (2004) 160-167
14. Tringler B., Gup C.J., Singh M., et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 35 (2004) 689-696
15. Aoyama C., Liu P., Ostrzega N., et al. Histologic and immunohistochemical characteristics of neoplastic and nonneoplastic subgroups of atypical squamous lesions of the uterine cervix. Am J Clin Pathol 123 (2005) 699-706
16. Carozzi F., Cecchini S., Confortini M., et al. Role of p16(INK4A) expression in identifying CIN2 or mores lesions among HPV-positive patients referred for colposcopy after abnormal cytology. Cancer Cytopathol 108 (2006) 119-123
17. Trunk M.J., Dallenbach-Hellweg G., Ridder R., et al. Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples. Acta Cytol 48 (2004) 771-782
18. Negri G., Vittadello F., Romano F., et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch 445 (2004) 616-620
19. Lei M. The MCM complex: its role in DNA replication and implications for cancer therapy. Curr Cancer Drug Targets 5 (2005) 365-380
20. Brake T., Connor J.P., Petereit D.G., et al. Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res 63 (2003) 8173-8180
21. Davidson E.J., Morris L.S., Scott I.S., et al. Minichromosome maintenance (Mcm) proteins, cyclin B1 and D1, phosphohistone H3 and in situ DNA replication for functional analysis of vulval intraepithelial neoplasia. Br J Cancer 88 (2003) 257-262
22. Wang J.C. Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 3 (2002) 430-440
23. Gibbons D., Fogt F., Kasznica J., et al. Comparison of topoisomerase II alpha and MIB-1 expression in uterine cervical squamous lesions. Mod Pathol 10 (1997) 409-413
24. Kelly D., Kincaid E., Fansler Z., et al. Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProExTMC). Cancer 108 (2006) 494-500
25. Shroyer KR, Homer P, Heinz D, et al. Validation of a novel immunocytochemical assay for topoisomerase II-a and minichromosome maintenance protein 2 expression in cervical cytology. Cancer 2006; 108:324-330.
26. Lin F., Yang W., Betten M., et al. Expression of S-100 protein in renal cell neoplasms. Hum Pathol 37 (2006) 462-470
27. Solomon D., and Nayar R. The Bethesda system for reporting cervical cytology. 2nd ed. (2004), Springer, New York 67-89
28. Choudhury M., and Singh S. Detection of HPV16 and 18 by in situ hybridization in precancerous and cancerous lesions. Indian J Pathol Microbiol 49 (2006) 345-347
29. Keating J.T., Cviko A., Riethdorf S., et al. Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol 25 (2001) 884-891
30. Freeman A., Morris L.S., Mills A.D., et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 5 (1999) 2121-2132
31. Kalof A.N., Evans M.F., Simmons-Arnold L., et al. p16INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia. Am J Surg Pathol 29 (2005) 674-679
32. Dray M., Russell P., Dalrymple C., et al. p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology 37 (2005) 112-124
33. Liu H., Shi J., Wilkerson M., et al. Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections. Cancer Cytopathol 111 (2007) 74-82