Loss of heterozygosity of the retinoblastoma and p53 genes in primary cervical carcinomas with human papillomavirus infection

Gynecologic Oncology

Volumn 67, Issue 2, 1997, Pages 215-221

  Kim, Jin Woo ^a,b   Lee, Chun Guen ^c   Han, Su Mi ^a,b   Kim, Kyung Suk ^a,b   Kim, Joo Oh ^a   Lee, Joon Mo ^a   Kim, In Kyung ^b   Namkoong, Sung Eun ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ALLELE; ARTICLE; CHROMOSOME LOSS; GENE LOCUS; GENE SEQUENCE; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; PAPILLOMA VIRUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA; WART VIRUS;

EID: 0031282222     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1997.4847     Document Type: Article

References (54)

1. zur Hausen H. Viruses in human cancer. Science. 254:1991;1167-1173.
2. Young L S, Bevan I S, Johnson M A, Blomfield P I, Bromidge T, Maitland N J, Woodman C BJ. The polymerase chain reaction: a new epidemiologic tool for investigating cervical human papillomavirus infection. Br Med J. 298:1989;14-18.
3. zur Hausen H. Papillomavirus in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res. 49:1989;4677-4681.
4. Bishop J M. Molecular themes in oncogenesis. Cell. 64:1991;235-248.
5. Riou G, Barrois M, Dutronquay V, Orth G. Presence of Papillomavirus DNA Sequences, Amplification of c-myc and H-ras Oncogenes, and Enhanced Expression of c-myc in Carcinomas of the Uterine Cervix. Papillomaviruses, Molecular and Clinical Aspects. 1985;A. R. Liss, New York. p. 47-56.
6. Ocadiz R, Sauceda R, Cruz M, Graef A M, Garglio P. High correlation between molecular alterations of the c-myc oncogene and carcinoma of the uterine cervix. Cancer Res. 47:1987;4173-4177.
7. Marshall C J. Tumor suppressor genes. Cell. 64:1991;313-326.
8. Goddard A D, Solomon E. Genetic Aspects of Cancer. Harris H, Hirschhorn K. Advances in Human Genetics. 1993;321-376 Plenum, New York.
9. Yokoda J, Tsukada Y, Nakajima T, Gotoh M, Shimosato Y, Mori N, Tsunokawa Y, Sugimura T, Terada M. Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res. 49:1989;3598-3601.
10. Mitra A B, Murty V VVS, Li R G, Pratap M, Luthra U K, Chaganti R SK. Allelotype analysis of cervical carcinoma. Cancer Res. 54:1994;4481-4487.
11. Srivatsan E S, Misra B C, Venugopalan M, Wilczynski S P. Loss of heterozygosity for alleles on chromosome 11 in cervical carcinoma. Am J Hum Genet. 49:1991;868-877.
12. Mullokandov M R, Kholodilov N G, Atkin N B, Burk R D, Johnson A B, Klinger H P. Genomic alterations in cervical carcinoma: loss of chromosome heterozygosity and human papilloma virus tumor status. Cancer Res. 56:1996;197-205.
13. Knudson A G. Antioncogenes and human cancer. Proc Natl Acad Sci USA. 90:1993;10914-10921.
14. Crook T, Wrede D, Tidy J A, Mason W P, Evans D J, Vousden K H. Clonal p53 mutation in primary cervical cancer: association with human papilloma virus-negative tumors. Lancet. 339:1992;1070-1073.
15. Fujita M, Inoue M, Tanizawa O, Iwamota S, Enomoto T. Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection. Cancer Res. 52:1992;5323-5328.
16. Tidy J A, Wrede D. Tumor suppressor genes: new pathways to gynecologic cancer. Int J Gynecol Cancer. 2:1992;1-8.
17. Park S Y, Kang Y S, Kim B G, Lee S H, Lee E D, Lee K H, Park K B, Lee J H. Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas. Cancer Genet Cytogenet. 79:1995;74-78.
18. Int J Gynecol Obstet. 25:1987;87.
19. Blin N, Stafford D M. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:1976;2303-2308.
20. Ferre F, Garduno F. Detection of human papillomavirus types 6/11, 16 and 18 using the polymerase chain reaction. Cancer Cells. 7:1989;215-218.
21. Evander M, Boden E, Bjersing L, Rylander E, Wadell G. Oligonucleotide primers for DNA amplification of the early regions 1, 6, and 7 from human papillomavirs types 6, 11, 16, 18, 31, and 33. Arch Virol. 116:1991;221-233.
22. Southern E M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 98:1975;504-517.
23. Lee W H, Bookstein R, Hong F, Young L J, Shew J Y, Lee Y HP. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science. 235:1987;1384-1399.
24. Yandell D W, Dryja D P. Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing. Am J Hum Genet. 45:1989;547-555.
25. Bookstein R, Lai C C, To H, Lee W H. PCR-based detection of a polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) gene. Nucleic Acids Res. 18:1990;1666.
26. McGee T L, Cowley G S, Yandell D W, Dryja T P. Detection of the XbaI RFLP within the retinoblastoma locus by PCR. Nucleic Acids Res. 18:1990;207.
27. Ara S, Lee P SY, Hansen M F, Saya H. Codon 72 polymorphism of the TP53 gene. Nucleic Acids Res. 18:1990;4691.
28. McDaniel T, Carbone D, Takahashi T, Chumakov P, Chang E H, Pirollo K F, Yin J, Meltzer S J. TheMsp. Nucleic Acids Res. 19:1991;4796.
29. Jones M H, Nakamura Y. Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide polymorphism. Gene Chromosome Cancer. 5:1992;89-90.
30. Horn G T, Richards B, Klinger K W. Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction. Nucleic Acids Res. 17:1980;2140.
31. Kim C J, Kim W H, Kim C W, Lee C K, Kim Y I. Detection of 17p loss in gastric carcinoma using polymerase chain reaction. Lab Invest. 72:1995;232-236.
32. Buchman V L, Chumakov P M, Ninkina N N, Samarina O P, Georgiev G P. A variation in the structure of the protein-coding regions of the human p53 gene. Gene. 70:1988;245-252.
33. Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA. 86:1989;2766-2770.
34. Yokoda J, Wada M, Shimosato Y, Terada M, Sugimura T. Loss of heterozygosity on chromosome 3, 13, and 17 in small cell carcinoma and on chromosome 3 in the adenocarcinoma of the lung. Proc Natl Acad Sci USA. 84:1987;9252-9256.
35. Lee J H, Kavanagh J J, Wildrich D M, Wharton J T, Blink M. Frequent loss of heterozygosity on chromosome 6q, 11 and 17 in human ovarian carcinoma. Cancer Res. 50:1990;2724-2728.
36. Hamann U, Herbold C, Costa S, Solomayer E F, Kaufmann M, Bastert G, Ulmer H U, Frenzel H, Komitowski D. Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer. Cancer Res. 56:1996;1988-1990.
37. Hawley-Nelson P, Vousden K H, Hubbert N L, Lowy D R, Schiller J T. HPV 16 E6 and E7 proteins cooperate to immotalize human foreskin keratinocytes. EMBO J. 8:1989;3905-3910.
38. Scheffner M, Munger K, Byrne J C, Hawley P M. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc Natl Acad Sci USA. 88:1991;5523-5527.
39. Helland A, Holm R, Kristensen G, Kaern F, Trope C, Nesland J M, Borresen A L. Genetic alterations of the tp53 gene, p53 protein expression and HPV infection in primary cervical carcinomas. J Pathol. 171:1993;105-114.
40. Pao C C, Kao S M, Chen J H, Tang G C, Chang P Y, Tan T T. State of mutational alterations of p53 and retinoblastoma susceptibility genes in papillomavirus-negative small cell cervical carcinomas. J Surg Oncol. 57:1994;87-93.
41. Rodriguez E, Sreekantaiah C, Chaganti R SK. Genetic changes in epithelial solid neoplasia. Cancer Res. 54:1994;3398-3406.
42. Greenwald B D, Harpaz N, Yin J, Huang Y, Tong Y, Brown V L, McDaniel T, Newkirk C, Resau J H, Meltzer S J. Loss of heterozygosity affecting p53, Rb and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res. 52:1992;741-745.
43. Jones M H, Koi S, Fujimoto K, Hasumi K, Kata K, Nakamura Y. Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p. Gene Chromosome Cancer. 9:1994;119-123.
44. Namkoong S E. Clinical application of HPV typing in cervical cancer. Int J Gynecol Obstet. 49:1995;S59-S67.
45. Kaelbling M, Burk R D, Atkin N B, Johnson A B, Klinger H P. Loss of hetrozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas. Lancet. 340:1992;140-142.
46. Srivastava S, Tong Y A, Devadas K, Zou Z Q, Chen Y W, Pirollo K F, Chang E H. The status of the p53 gene in human papilloma virus positive or negative cervical carcinoma cell lines. Carcinogenesis. 13:1992;1273-1275.
47. Park D J, Wilczynski S P, Paquette R L, Miller C W, Koeffler H P. p53 mutations in HPV-negative cervical carcinoma. Oncogene. 9:1994;205-210.
48. Choo K B, Chong K Y. Absence of mutation in the p53 and the retinoblastoma susceptibility genes in primary cervical carcinomas. Virology. 193:1993;1042-1046.
49. Wrede D, Tidy J, Crook T, Lane D, Vousden K H. Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines. Mol Carcinogen. 4:1991;171-175.
50. Tsuda H, Hirohashi S. Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes. Jpn J Cancer Res. 83:1992;1184-1191.
51. Xu H J, Cairns P, Hu S X, Knowles M A, Benedict W F. Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the Rb locus and tumor progression. Int J Cancer. 53:1993;781-784.
52. Kim T M, Benedict W F, Xu H J, Hu S X, Gosewehr J, Velicescu M, Yin E, Zheng J, D'Ablaing G, Dubeau L. Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res. 54:1994;605-609.
53. Wadayama B I, Toguchida J, Shimizu T, Ishizaki K, Sasaki M S, Kotoura Y, Yamamuro T. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res. 54:1994;3042-3048.
54. Dodson M K, Cliby W A, Xu H J, DeLacey K A, Hu S X, Keeney G L, Li J, Podratz K C, Jenkins R B, Benedict W F. Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus. Cancer Res. 54:1994;610-613.