메뉴 건너뛰기




Volumn 95, Issue 8, 2013, Pages 983-990

The aryl hydrocarbon receptor: A novel target for immunomodulation in organ transplantation

Author keywords

Aryl hydrocarbon receptor; Autoimmunity; Environment; Immunomodulation; T cell differentiation

Indexed keywords

2 (1H INDOLE 3 CARBONYL)THIAZOLE 4 CARBOXYLIC ACID METHYL ESTER; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; AROMATIC HYDROCARBON RECEPTOR; CARBOXYLIC ACID DERIVATIVE; CIGARETTE SMOKE; CYTOCHROME P450; GAMMA INTERFERON; GLYCOPROTEIN P 15095; IMMUNOMODULATING AGENT; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 17; INTERLEUKIN 6; KYNURENINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON; SEMAXANIB; UNCLASSIFIED DRUG; VAF 347; VASCULOTROPIN RECEPTOR 2;

EID: 84876693055     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31827a3d1d     Document Type: Review
Times cited : (21)

References (93)
  • 1
  • 2
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    • Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003; 43: 309.
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 309
    • Denison, M.S.1    Nagy, S.R.2
  • 3
    • 34249339752 scopus 로고    scopus 로고
    • Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway
    • Kitamura M, Kasai A. Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway. Cancer Lett 2007; 252: 184.
    • (2007) Cancer Lett , vol.252 , pp. 184
    • Kitamura, M.1    Kasai, A.2
  • 4
    • 0028020048 scopus 로고
    • Dioxin-receptor ligands in urban air and vehicle exhaust
    • Mason GG. Dioxin-receptor ligands in urban air and vehicle exhaust. Environ Health Perspect 1994; 102: 111.
    • (1994) Environ Health Perspect , vol.102 , pp. 111
    • Mason, G.G.1
  • 5
    • 0037156460 scopus 로고    scopus 로고
    • Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment
    • Hahn ME. Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment. Sci Total Environ 2002; 289: 49.
    • (2002) Sci Total Environ , vol.289 , pp. 49
    • Hahn, M.E.1
  • 6
    • 0034233373 scopus 로고    scopus 로고
    • Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo
    • Walker MK, Heid SE, Smith SM, et al. Molecular characterization and developmental expression of the aryl hydrocarbon receptor from the chick embryo. Comp Biochem Physiol C Toxicol Pharmacol 2000; 126: 305.
    • (2000) Comp Biochem Physiol C Toxicol Pharmacol , vol.126 , pp. 305
    • Walker, M.K.1    Heid, S.E.2    Smith, S.M.3
  • 7
    • 38949097735 scopus 로고    scopus 로고
    • The search for endogenous activators of the aryl hydrocarbon receptor
    • Nguyen LP, Bradfield CA. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 2008; 21: 102.
    • (2008) Chem Res Toxicol , vol.21 , pp. 102
    • Nguyen, L.P.1    Bradfield, C.A.2
  • 8
    • 9344230351 scopus 로고    scopus 로고
    • Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development
    • Walisser JA, Bunger MK, Glover E, et al. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 2004; 101: 16677.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16677
    • Walisser, J.A.1    Bunger, M.K.2    Glover, E.3
  • 9
    • 1942501666 scopus 로고    scopus 로고
    • Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele
    • Walisser JA, Bunger MK, Glover E, et al. Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele. J Biol Chem 2004; 279: 16326.
    • (2004) J Biol Chem , vol.279 , pp. 16326
    • Walisser, J.A.1    Bunger, M.K.2    Glover, E.3
  • 10
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    • Martin B, Hirota K, Cua DJ, et al. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009; 31: 321.
    • (2009) Immunity , vol.31 , pp. 321
    • Martin, B.1    Hirota, K.2    Cua, D.J.3
  • 12
    • 47749107262 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
    • Kimura A, Naka T, Nohara K, et al. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A 2008; 105: 9721.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9721
    • Kimura, A.1    Naka, T.2    Nohara, K.3
  • 13
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • Li Y, Innocentin S, Withers DR, et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011; 147: 629.
    • (2011) Cell , vol.147 , pp. 629
    • Li, Y.1    Innocentin, S.2    Withers, D.R.3
  • 14
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • Kiss EA, Vonarbourg C, Kopfmann S, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 2011; 334: 1561.
    • (2011) Science , vol.334 , pp. 1561
    • Kiss, E.A.1    Vonarbourg, C.2    Kopfmann, S.3
  • 15
    • 84855917402 scopus 로고    scopus 로고
    • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    • Lee JS, Cella M, McDonald KG, et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol 2012; 13: 144.
    • (2012) Nat Immunol , vol.13 , pp. 144
    • Lee, J.S.1    Cella, M.2    McDonald, K.G.3
  • 17
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana FJ, Basso AS, Iglesias AH, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008; 453: 65.
    • (2008) Nature , vol.453 , pp. 65
    • Quintana, F.J.1    Basso, A.S.2    Iglesias, A.H.3
  • 18
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins
    • Veldhoen M, Hirota K, Westendorf AM, et al. The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins. Nature 2008; 453: 106.
    • (2008) Nature , vol.453 , pp. 106
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3
  • 19
    • 80055116357 scopus 로고    scopus 로고
    • The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis
    • Ruan Q, Kameswaran V, Zhang Y, et al. The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis. J Exp Med 2011; 208: 2321.
    • (2011) J Exp Med , vol.208 , pp. 2321
    • Ruan, Q.1    Kameswaran, V.2    Zhang, Y.3
  • 20
    • 77956469491 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells
    • Ramirez JM, Brembilla NC, Sorg O, et al. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol 2010; 40: 2450.
    • (2010) Eur J Immunol , vol.40 , pp. 2450
    • Ramirez, J.M.1    Brembilla, N.C.2    Sorg, O.3
  • 21
    • 2342458559 scopus 로고    scopus 로고
    • Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    • Pan H, Hong F, Radaeva S, et al. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 2004; 1: 43.
    • (2004) Cell Mol Immunol , vol.1 , pp. 43
    • Pan, H.1    Hong, F.2    Radaeva, S.3
  • 22
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 2007; 27: 647.
    • (2007) Immunity , vol.27 , pp. 647
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3
  • 23
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • Wolk K, Kunz S, Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21: 241.
    • (2004) Immunity , vol.21 , pp. 241
    • Wolk, K.1    Kunz, S.2    Witte, E.3
  • 24
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281: 1191.
    • (1998) Science , vol.281 , pp. 1191
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 25
    • 54049151564 scopus 로고    scopus 로고
    • The indoleamine 2, 3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    • Chen W, Liang X, Peterson AJ, et al. The indoleamine 2, 3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol 2008; 181: 5396.
    • (2008) J Immunol , vol.181 , pp. 5396
    • Chen, W.1    Liang, X.2    Peterson, A.J.3
  • 26
    • 0034176031 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation
    • Hwu P, Du MX, Lapointe R, et al. Indoleamine 2, 3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000; 164: 3596.
    • (2000) J Immunol , vol.164 , pp. 3596
    • Hwu, P.1    Du, M.X.2    Lapointe, R.3
  • 27
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    • Fallarino F, Grohmann U, You S, et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006; 176: 6752.
    • (2006) J Immunol , vol.176 , pp. 6752
    • Fallarino, F.1    Grohmann, U.2    You, S.3
  • 28
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • Mezrich JD, Fechner JH, Zhang X, et al. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010; 185: 3190.
    • (2010) J Immunol , vol.185 , pp. 3190
    • Mezrich, J.D.1    Fechner, J.H.2    Zhang, X.3
  • 29
    • 78650547540 scopus 로고    scopus 로고
    • An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
    • Quintana FJ, Murugaiyan G, Farez MF, et al. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2010; 107: 20768.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20768
    • Quintana, F.J.1    Murugaiyan, G.2    Farez, M.F.3
  • 31
    • 77951757558 scopus 로고    scopus 로고
    • Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent
    • Saunders V, Breysse P, Clark J, et al. Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent. Environ Health Perspect 2010; 118: 640.
    • (2010) Environ Health Perspect , vol.118 , pp. 640
    • Saunders, V.1    Breysse, P.2    Clark, J.3
  • 32
    • 79957613753 scopus 로고    scopus 로고
    • IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
    • Chen K, Pociask DA, McAleer JP, et al. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One 2011; 6: e20333.
    • (2011) PLoS One , vol.6
    • Chen, K.1    Pociask, D.A.2    McAleer, J.P.3
  • 33
    • 77649190726 scopus 로고    scopus 로고
    • Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance
    • Ishimaru N, Takagi A, Kohashi M, et al. Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance. J Immunol 2009; 182: 6576.
    • (2009) J Immunol , vol.182 , pp. 6576
    • Ishimaru, N.1    Takagi, A.2    Kohashi, M.3
  • 34
    • 80054041992 scopus 로고    scopus 로고
    • An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
    • Opitz CA, Litzenburger UM, Sahm F, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 2011; 478: 197.
    • (2011) Nature , vol.478 , pp. 197
    • Opitz, C.A.1    Litzenburger, U.M.2    Sahm, F.3
  • 35
    • 38449120554 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice
    • Shi LZ, Faith NG, Nakayama Y, et al. The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice. J Immunol 2007; 179: 6952.
    • (2007) J Immunol , vol.179 , pp. 6952
    • Shi, L.Z.1    Faith, N.G.2    Nakayama, Y.3
  • 37
    • 34250897888 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells
    • Neff-LaFord H, Teske S, Bushnell TP, et al. Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells. J Immunol 2007; 179: 247.
    • (2007) J Immunol , vol.179 , pp. 247
    • Neff-Laford, H.1    Teske, S.2    Bushnell, T.P.3
  • 38
    • 84855274941 scopus 로고    scopus 로고
    • Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling
    • Veiga-Parga T, Suryawanshi A, Rouse BT. Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling. PLoS Pathog 2011; 7: e1002427.
    • (2011) PLoS Pathog , vol.7
    • Veiga-Parga, T.1    Suryawanshi, A.2    Rouse, B.T.3
  • 39
    • 80052155367 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis
    • Nakahama T, Kimura A, Nguyen NT, et al. Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. Proc Natl Acad Sci U S A 2011; 108: 14222.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14222
    • Nakahama, T.1    Kimura, A.2    Nguyen, N.T.3
  • 40
    • 49449095646 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound
    • Lawrence BP, Denison MS, Novak H, et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood 2008; 112: 1158.
    • (2008) Blood , vol.112 , pp. 1158
    • Lawrence, B.P.1    Denison, M.S.2    Novak, H.3
  • 41
    • 79959918506 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
    • Monteleone I, Rizzo A, Sarra M, et al. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology 2011; 141: 237.
    • (2011) Gastroenterology , vol.141 , pp. 237
    • Monteleone, I.1    Rizzo, A.2    Sarra, M.3
  • 42
    • 80054720170 scopus 로고    scopus 로고
    • A role of the aryl hydrocarbon receptor in attenuation of colitis
    • Furumatsu K, Nishiumi S, Kawano Y, et al. A role of the aryl hydrocarbon receptor in attenuation of colitis. Dig Dis Sci 2011; 56: 2532.
    • (2011) Dig Dis Sci , vol.56 , pp. 2532
    • Furumatsu, K.1    Nishiumi, S.2    Kawano, Y.3
  • 43
    • 80053906324 scopus 로고    scopus 로고
    • Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis
    • Takamura T, Harama D, Fukumoto S, et al. Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunol Cell Biol 2011; 89: 817.
    • (2011) Immunol Cell Biol , vol.89 , pp. 817
    • Takamura, T.1    Harama, D.2    Fukumoto, S.3
  • 44
    • 0022327471 scopus 로고
    • The role of receptors in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity
    • Dencker L. The role of receptors in 2, 3, 7, 8-tetrachlorodibenzo-p- dioxin (TCDD) toxicity. Arch Toxicol Suppl 1985; 8: 43.
    • (1985) Arch Toxicol Suppl , vol.8 , pp. 43
    • Dencker, L.1
  • 45
    • 20044391611 scopus 로고    scopus 로고
    • Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes
    • Nohara K, Pan X, Tsukumo S, et al. Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. J Immunol 2005; 174: 2770.
    • (2005) J Immunol , vol.174 , pp. 2770
    • Nohara, K.1    Pan, X.2    Tsukumo, S.3
  • 46
    • 34250362766 scopus 로고    scopus 로고
    • 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin induces premature activation of the KLF2 regulon during thymocyte development
    • McMillan BJ, McMillan SN, Glover E, et al. 2, 3, 7, 8-Tetrachlorodibenzo- p-dioxin induces premature activation of the KLF2 regulon during thymocyte development. J Biol Chem 2007; 282: 12590.
    • (2007) J Biol Chem , vol.282 , pp. 12590
    • McMillan, B.J.1    McMillan, S.N.2    Glover, E.3
  • 47
    • 84857654659 scopus 로고    scopus 로고
    • Cigarette smoke exposure hinders longterm allograft survival by suppressing indoleamine 2, 3-dioxygenase expression
    • Wan F, Dai H, Zhang S, et al. Cigarette smoke exposure hinders longterm allograft survival by suppressing indoleamine 2, 3-dioxygenase expression. Am J Transplant 2012; 12: 610.
    • (2012) Am J Transplant , vol.12 , pp. 610
    • Wan, F.1    Dai, H.2    Zhang, S.3
  • 48
    • 84856016415 scopus 로고    scopus 로고
    • Diet and intestinal immunity
    • Tilg H. Diet and intestinal immunity. N Engl J Med 2012; 366: 181.
    • (2012) N Engl J Med , vol.366 , pp. 181
    • Tilg, H.1
  • 49
    • 84862303080 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor in inflammatory bowel disease: Linking the environment to disease pathogenesis
    • Monteleone I, MacDonald TT, Pallone F, et al. The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis. Curr Opin Gastroenterol 2012; 28: 310.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 310
    • Monteleone, I.1    MacDonald, T.T.2    Pallone, F.3
  • 50
    • 80051893554 scopus 로고    scopus 로고
    • The impact of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung transplantation
    • Nawrot TS, Vos R, Jacobs L, et al. The impact of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung transplantation. Thorax 2011; 66: 748.
    • (2011) Thorax , vol.66 , pp. 748
    • Nawrot, T.S.1    Vos, R.2    Jacobs, L.3
  • 51
    • 79955532795 scopus 로고    scopus 로고
    • Neutralizing IL-17 prevents oblit-erative bronchiolitis in murine orthotopic lung transplantation
    • Fan L, Benson HL, Vittal R, et al. Neutralizing IL-17 prevents oblit-erative bronchiolitis in murine orthotopic lung transplantation. Am J Transplant 2011; 11: 911.
    • (2011) Am J Transplant , vol.11 , pp. 911
    • Fan, L.1    Benson, H.L.2    Vittal, R.3
  • 52
    • 49649126383 scopus 로고    scopus 로고
    • The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation
    • Vanaudenaerde BM, De Vleeschauwer SI, Vos R, et al. The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. Am J Transplant 2008; 8: 1911.
    • (2008) Am J Transplant , vol.8 , pp. 1911
    • Vanaudenaerde, B.M.1    De Vleeschauwer, S.I.2    Vos, R.3
  • 53
    • 36048968753 scopus 로고    scopus 로고
    • IL-17-dependent cellular immunity to collagen type v predisposes to obliterative bron-chiolitis in human lung transplants
    • Burlingham WJ, Love RB, Jankowska-Gan E, et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bron-chiolitis in human lung transplants. J Clin Invest 2007; 117: 3498.
    • (2007) J Clin Invest , vol.117 , pp. 3498
    • Burlingham, W.J.1    Love, R.B.2    Jankowska-Gan, E.3
  • 54
    • 84863208318 scopus 로고    scopus 로고
    • Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution
    • Verleden SE, Scheers H, Nawrot TS, et al. Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution. Am J Transplant 2012; 12: 1831.
    • (2012) Am J Transplant , vol.12 , pp. 1831
    • Verleden, S.E.1    Scheers, H.2    Nawrot, T.S.3
  • 55
    • 51649101135 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells
    • Hauben E, Gregori S, Draghici E, et al. Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood 2008; 112: 1214.
    • (2008) Blood , vol.112 , pp. 1214
    • Hauben, E.1    Gregori, S.2    Draghici, E.3
  • 56
    • 84863306512 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor influences transplant outcomes in response to environmental signals
    • Pauly SK, Fechner JH, Zhang XJ, et al. The aryl hydrocarbon receptor influences transplant outcomes in response to environmental signals. Toxicol Environ Chem 2012; 94: 1175.
    • (2012) Toxicol Environ Chem , vol.94 , pp. 1175
    • Pauly, S.K.1    Fechner, J.H.2    Zhang, X.J.3
  • 57
    • 84863949288 scopus 로고    scopus 로고
    • Nanoparticle-mediated codeli-very of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis
    • Yeste A, Nadeau M, Burns EJ, et al. Nanoparticle-mediated codeli-very of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2012; 109: 11270.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11270
    • Yeste, A.1    Nadeau, M.2    Burns, E.J.3
  • 58
    • 84866077937 scopus 로고    scopus 로고
    • SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation
    • Mezrich JD, Nguyen LP, Kennedy G, et al. SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. PLoS One 2012; 7: e44547.
    • (2012) PLoS One , vol.7
    • Mezrich, J.D.1    Nguyen, L.P.2    Kennedy, G.3
  • 59
    • 77949385479 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways
    • Kim YS, Hong SW, Choi JP, et al. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol 2009; 183: 5113.
    • (2009) J Immunol , vol.183 , pp. 5113
    • Kim, Y.S.1    Hong, S.W.2    Choi, J.P.3
  • 60
    • 64549147068 scopus 로고    scopus 로고
    • VEGF and angiogenesis in acute and chronic MOG((35Y55)) peptide induced EAE
    • Roscoe WA, Welsh ME, Carter DE, et al. VEGF and angiogenesis in acute and chronic MOG((35Y55)) peptide induced EAE. J Neu-roimmunol 2009; 209: 6.
    • (2009) J Neu-roimmunol , vol.209 , pp. 6
    • Roscoe, W.A.1    Welsh, M.E.2    Carter, D.E.3
  • 61
    • 34247857744 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    • Thatcher TH, Maggirwar SB, Baglole CJ, et al. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol 2007; 170: 855.
    • (2007) Am J Pathol , vol.170 , pp. 855
    • Thatcher, T.H.1    Maggirwar, S.B.2    Baglole, C.J.3
  • 62
    • 3343015661 scopus 로고    scopus 로고
    • Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury
    • Jiang W, Welty SE, Couroucli XI, et al. Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J Pharmacol Exp Ther 2004; 310: 512.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 512
    • Jiang, W.1    Welty, S.E.2    Couroucli, X.I.3
  • 63
    • 69449101827 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
    • Kawajiri K, Kobayashi Y, Ohtake F, et al. Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A 2009; 106: 13481.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13481
    • Kawajiri, K.1    Kobayashi, Y.2    Ohtake, F.3
  • 64
    • 84856237141 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    • Qiu J, Heller JJ, Guo X, et al. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2012; 36: 92.
    • (2012) Immunity , vol.36 , pp. 92
    • Qiu, J.1    Heller, J.J.2    Guo, X.3
  • 65
    • 0034464537 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse
    • Robles R, Morita Y, Mann KK, et al. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology 2000; 141: 450.
    • (2000) Endocrinology , vol.141 , pp. 450
    • Robles, R.1    Morita, Y.2    Mann, K.K.3
  • 66
    • 0036667370 scopus 로고    scopus 로고
    • Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice
    • Lin TM, Ko K, Moore RW, et al. Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 2002; 68: 479.
    • (2002) Toxicol Sci , vol.68 , pp. 479
    • Lin, T.M.1    Ko, K.2    Moore, R.W.3
  • 67
    • 0034641727 scopus 로고    scopus 로고
    • Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice
    • Lahvis GP, Lindell SL, Thomas RS, et al. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A 2000; 97: 10442.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10442
    • Lahvis, G.P.1    Lindell, S.L.2    Thomas, R.S.3
  • 68
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
    • Schmidt JV, Su GH, Reddy JK, et al. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A 1996; 93: 6731.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6731
    • Schmidt, J.V.1    Su, G.H.2    Reddy, J.K.3
  • 69
    • 80053091415 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis
    • Kadow S, Jux B, Zahner SP, et al. Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis. J Immunol 2011; 187: 3104.
    • (2011) J Immunol , vol.187 , pp. 3104
    • Kadow, S.1    Jux, B.2    Zahner, S.P.3
  • 70
    • 81855190624 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by TCDD inhibits mammary tumor metastasis in a syngeneic mouse model of breast cancer
    • Wang T, Wyrick KL, Meadows GG, et al. Activation of the aryl hydrocarbon receptor by TCDD inhibits mammary tumor metastasis in a syngeneic mouse model of breast cancer. Toxicol Sci 2011; 124: 291.
    • (2011) Toxicol Sci , vol.124 , pp. 291
    • Wang, T.1    Wyrick, K.L.2    Meadows, G.G.3
  • 71
    • 0037026632 scopus 로고    scopus 로고
    • Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer
    • Koliopanos A, Kleeff J, Xiao Y, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene 2002; 21: 6059.
    • (2002) Oncogene , vol.21 , pp. 6059
    • Koliopanos, A.1    Kleeff, J.2    Xiao, Y.3
  • 72
    • 84863990840 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells
    • O'Donnell EF, Kopparapu PR, Koch DC, et al. The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. PLoS One 2012; 7: e40926.
    • (2012) PLoS One , vol.7
    • O'Donnell, E.F.1    Kopparapu, P.R.2    Koch, D.C.3
  • 73
    • 33744965938 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and ly-sosomal disruption in a hepatoma model that is caspase-8-independent
    • Caruso JA, Mathieu PA, Joiakim A, et al. Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and ly-sosomal disruption in a hepatoma model that is caspase-8-independent. J Biol Chem 2006; 281: 10954.
    • (2006) J Biol Chem , vol.281 , pp. 10954
    • Caruso, J.A.1    Mathieu, P.A.2    Joiakim, A.3
  • 74
    • 59149083365 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by TCDD inhibits senescence: A tumor promoting event?
    • Ray S, Swanson HI. Activation of the aryl hydrocarbon receptor by TCDD inhibits senescence: a tumor promoting event? Biochem Pharmacol 2009; 77: 681.
    • (2009) Biochem Pharmacol , vol.77 , pp. 681
    • Ray, S.1    Swanson, H.I.2
  • 75
    • 2642510760 scopus 로고    scopus 로고
    • Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    • Nebert DW, Dalton TP, Okey AB, et al. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 2004; 279: 23847.
    • (2004) J Biol Chem , vol.279 , pp. 23847
    • Nebert, D.W.1    Dalton, T.P.2    Okey, A.B.3
  • 76
    • 33749235345 scopus 로고    scopus 로고
    • Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response
    • Vorderstrasse BA, Lawrence BP. Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response. Infect Immun 2006; 74: 5679.
    • (2006) Infect Immun , vol.74 , pp. 5679
    • Vorderstrasse, B.A.1    Lawrence, B.P.2
  • 77
    • 84862317958 scopus 로고    scopus 로고
    • Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection
    • Wang T, Wyrick KL, Pecka MR, et al. Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection. Int Immunopharmacol 2012; 13: 490.
    • (2012) Int Immunopharmacol , vol.13 , pp. 490
    • Wang, T.1    Wyrick, K.L.2    Pecka, M.R.3
  • 78
    • 20844458617 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus
    • Teske S, Bohn AA, Regal JF, et al. Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus. Am J Physiol Lung Cell Mol Physiol 2005; 289: L111.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289
    • Teske, S.1    Bohn, A.A.2    Regal, J.F.3
  • 79
    • 84860604269 scopus 로고    scopus 로고
    • Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells
    • Yoshida T, Katsuya K, Oka T, et al. Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells. Biomed Res 2012; 33: 67.
    • (2012) Biomed Res , vol.33 , pp. 67
    • Yoshida, T.1    Katsuya, K.2    Oka, T.3
  • 80
    • 84860340499 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated induction of EBV reactivation as a risk factor for Sjogren's syndrome
    • Inoue H, Mishima K, Yamamoto-Yoshida S, et al. Aryl hydrocarbon receptor-mediated induction of EBV reactivation as a risk factor for Sjogren's syndrome. J Immunol 2012; 188: 4654.
    • (2012) J Immunol , vol.188 , pp. 4654
    • Inoue, H.1    Mishima, K.2    Yamamoto-Yoshida, S.3
  • 81
    • 81255195680 scopus 로고    scopus 로고
    • Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection
    • Elizondo G, Rodriguez-Sosa M, Estrada-Muniz E, et al. Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection. Int J Biol Sci 2011; 7: 1220.
    • (2011) Int J Biol Sci , vol.7 , pp. 1220
    • Elizondo, G.1    Rodriguez-Sosa, M.2    Estrada-Muniz, E.3
  • 82
    • 80053439214 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model
    • Schulz VJ, Smit JJ, Willemsen KJ, et al. Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model. Toxicol Sci 2011; 123: 491.
    • (2011) Toxicol Sci , vol.123 , pp. 491
    • Schulz, V.J.1    Smit, J.J.2    Willemsen, K.J.3
  • 83
    • 74549144224 scopus 로고    scopus 로고
    • Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: Possible mechanisms for lung dysfunction
    • Wong PS, Vogel CF, Kokosinski K, et al. Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction. Am J Respir Cell Mol Biol 2010; 42: 210.
    • (2010) Am J Respir Cell Mol Biol , vol.42 , pp. 210
    • Wong, P.S.1    Vogel, C.F.2    Kokosinski, K.3
  • 84
    • 77958464034 scopus 로고    scopus 로고
    • 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin impairs stable establishment of oral tolerance in mice
    • Chmill S, Kadow S, Winter M, et al. 2, 3, 7, 8-Tetrachlorodibenzo-p- dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci 2010; 118: 98.
    • (2010) Toxicol Sci , vol.118 , pp. 98
    • Chmill, S.1    Kadow, S.2    Winter, M.3
  • 85
    • 79251595271 scopus 로고    scopus 로고
    • Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production
    • Chiba T, Uchi H, Tsuji G, et al. Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production. Pulm Pharmacol Ther 2011; 24: 133.
    • (2011) Pulm Pharmacol Ther , vol.24 , pp. 133
    • Chiba, T.1    Uchi, H.2    Tsuji, G.3
  • 86
    • 80053016614 scopus 로고    scopus 로고
    • Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma
    • Zhu J, Cao Y, Li K, et al. Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. Asian Pac J Allergy Immunol 2011; 29: 266.
    • (2011) Asian Pac J Allergy Immunol , vol.29 , pp. 266
    • Zhu, J.1    Cao, Y.2    Li, K.3
  • 87
    • 80053453758 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages
    • Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol 2011; 23: 637.
    • (2011) Int Immunol , vol.23 , pp. 637
    • Masuda, K.1    Kimura, A.2    Hanieh, H.3
  • 88
    • 39949085215 scopus 로고    scopus 로고
    • Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
    • Podechard N, Lecureur V, Le Ferrec E, et al. Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. Toxicol Lett 2008; 177: 130.
    • (2008) Toxicol Lett , vol.177 , pp. 130
    • Podechard, N.1    Lecureur, V.2    Le Ferrec, E.3
  • 89
    • 79952096263 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's disease
    • Benson JM, Shepherd DM. Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's disease. Toxicol Sci 2011; 120: 68.
    • (2011) Toxicol Sci , vol.120 , pp. 68
    • Benson, J.M.1    Shepherd, D.M.2
  • 90
    • 80051676534 scopus 로고    scopus 로고
    • Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis
    • Singh NP, Singh UP, Singh B, et al. Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. PLoS One 2011; 6: e23522.
    • (2011) PLoS One , vol.6
    • Singh, N.P.1    Singh, U.P.2    Singh, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.