Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment

Science of the Total Environment

Volumn 289, Issue 1-3, 2002, Pages 49-69

  Hahn, Mark E ^a  

^a WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

Author keywords

Biomarkers; Cell culture bioassays; CYP1A1; Cytochrome P450; Dioxins; Hepatoma cells; Polychlorinated biphenyls; Reporter genes; Seafood

Indexed keywords

BIOASSAY; BIODIVERSITY; BIOMARKERS; CELL CULTURE; MARINE BIOLOGY; TOXICITY;

HUMANS; MARINE ENVIRONMENTS; SEAFOODS;

AROMATIC HYDROCARBONS;

AROMATIC HYDROCARBON; BIOLOGICAL MARKER; BIPHENYL DERIVATIVE; DIBENZOFURAN DERIVATIVE; DIOXIN; HYDROCARBON; RECEPTOR PROTEIN;

BIOASSAY; BIOMARKER; DETECTION METHOD; DIOXIN; MARINE POLLUTION; PCB; SEAFOOD;

ARTICLE; BIOASSAY; CELL CULTURE; CHEMICAL ANALYSIS; CONTAMINATION; CONTROLLED STUDY; DNA BINDING; EXPOSURE; GENE ACTIVATION; GENETIC TRANSCRIPTION; MARINE ENVIRONMENT; MONITORING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; REPORTER GENE; SAFETY; SEA FOOD;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CYTOCHROME P-450 CYP1A1; DIOXINS; DNA; ENVIRONMENTAL MONITORING; ENZYME INDUCTION; FOOD CONTAMINATION; HUMANS; LUCIFERASES; SEAFOOD; SENSITIVITY AND SPECIFICITY; TRANS-ACTIVATION (GENETICS); WATER POLLUTANTS, CHEMICAL;

ANIMALIA;

EID: 0037156460     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0048-9697(01)01016-6     Document Type: Article

References (237)

1. Organochlorines and marine mammal reproduction
2. Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept
3. Toxic equivalency factors for dioxin-like PCBs
4. Human health risks due to consumption of chemically contaminated fishery products
5. Risk assessment and management of chemical contaminants in fishery products consumed in the USA
6. Environmental problems caused by TBT in France: Assessment, regulations, prospects
7. A biomarker, P450 RGS, for assessing the induction potential of environmental samples
8. Bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in PCB-containing extracts from the flesh and eggs of Lake Michigan Chinook salmon (Oncorhynchus tshawytscha) and possible implications for reproduction
9. Is our fish fit to eat?
10. Researchers ready rapid Pfiesteria tests
11. Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography
12. Contamination of the deep-sea
13. Assessment of potential cancer risk from consumption of PCBs bioaccumulated in fish and shellfish
14. Health hazard assessment for chlorinated dioxins and dibenzofurans other than 2,3,7,8-TCDD
15. Acquired resistance to aryl hydrocarbon receptor agonists in a population of Fundulus heteroclitus from a marine Superfund site: In vivo and in vitro studies on the induction of xenobiotic-metabolizing enzymes
16. Direct electrochemical immunosensor for polychlorinated biphenyls
17. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYP1A inhibition
18. Toxicity of retene to early life stages of two freshwater species
19. Novel retinoic acid receptor ligands in Xenopus embryos
20. Use of liver cell lines to develop TCDD equivalency factors and to derive TCDD equivalent concentrations in environmental samples
21. Ability of polycyclic aromatic hydrocarbons to induce 7-ethoxyresorufin-o-deethylase activity in a trout liver cell line
22. Role of FDA in establishing tolerable levels for dioxin and PCBs in aquatic organisms
23. A competitive binding assay for 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands of the Ah receptor
24. Induction of enzyme activity in cell culture: A rapid screen for detection of planar polychlorinated organic compounds
25. Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin
26. Identification of two binding proteins for halogenated aromatic hydrocarbons in the hard-shell clam, Mercenaria mercenaria
27. An ELISA assay for cytochrome P4501A in fish liver cells
28. Induction of cytochrome P450 as a biomarker of environmental contamination in aquatic ecosystems
29. Fishing, consumption, and risk perception in fisherfolk along an East coast estuary
30. An aryl hydrocarbon receptor homologue from the soft-shell clam, Mya arenaria: Evidence that invertebrate AHR homologues lack TCDD and BNF binding
31. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): The embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in Medaka (Orizias latipes)
32. Glucocorticoid-xenobiotic interactions: Dexamethasone potentiation of cytochrome P4501A induction by b-naphthoflavone in a fish hepatoma cell line (PLHC-1)
33. Comparison of rat hepatocyte and differentiated hepatoma cell line cultures as bio-indicators of CYP 1A1 inducers in urban air
34. Toxic effects in C57B1/6 and DBA/2 mice following consumption of halogenated aromatic hydrocarbon-contaminated Great Lakes coho salmon (Oncorhynchus kisutch Walbaum)
35. Comparison of toxic equivalent factors for selected dioxin and furan congeners derived using fish and mammalian liver cell lines
36. Cytochrome P4501A1 induction by polychlorinated biphenyls (PCBs) in liver cell lines from rat and trout and the derivation of toxic equivalency factors (TEFs)
37. Biological markers in environmental health research
38. Risk assessment in a federal regulatory agency: An assessment of risk associated with the human consumption of some species of fish contaminated with polychlorinated biphenyls (PCBs)
39. Chemically contaminated aquatic food resources and human cancer risk
40. Biomarkers: Coming of age for environmental health and risk assessment
41. Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species
42. Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer
43. Natural and synthetic ligands for the Ah receptor (Chapter 23)
44. Status report on aquatic pollution problems in Europe
45. Monitoring brevetoxins during a Gymnodinium breve red tide: Comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts
46. A microassay for measuring cytochrome-P450IA1 and cytochrome-P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates
47. Development and preliminary validation of a microtiter plate-based receptor binding assay for paralytic shellfish poisoning toxins
48. Multidimendsional gas chromatography with electron capture detection for the determination of toxic congeners in polychlorinated biphenyl mixtures
49. Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures
50. Balancing fish consumption benefits with mercury exposure
51. Production of a novel recombinant cell line for use as a bioassay system for detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
52. Polychlorinated biphenyl congener distributions in winter flounder as related to gender, spawning site, and congener metabolism
53. Toxic potencies of lipophilic extracts from sediments and settling particulate matter (SPM) collected in a PCB-contaminated river system
54. Dioxin-like compounds in HPLC-fractionated extracts of marine samples from the East and West coast of Sweden: Bioassay- and instrumentally-derived TCDD equivalents
55. Reporter gene assays for algal-derived toxins
56. A cell-based assay for brevetoxins, saxitoxins, and ciguatoxins using a stably expressed c-fos-luciferase reporter gene
57. Reporter gene assay for fish-killing activity produced by Pfiesteria piscicida
58. U.S. 'mussel watch' 1976-1978: An overview of the trace-metal, DDE, PCB, hydrocarbon, and artificial nuclide data
59. 'Mussel Watch' - Measurements of chemical pollutants in bivalves as one indicator of coastal environmental quality
60. Cyochrome P4501A induction potencies of polycyclic aromatic hydrocarbons in a fish hepatoma cell line: Demonstration of additive interactions and an induction equivalency concept
61. Symposium overview: Toxicity of non-coplanar PCBs
62. Food and Drug Administration, USA, Proposal To Establish Procedures for the Safe Processing and Importing of Fish and Fishery Products
63. Chronic retene exposure causes sustained induction of CYP1A activity and protein in rainbow trout (Oncorhynchus mykiss)
64. Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: Comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations
65. TCDD receptor ligands present in extracts of urban air particulate matter induce aryl hydrocarbon hydroxylase activity and cytochrome P450c gene expression in rat hepatoma cells
66. The GESAMP evaluation of potentially harmful substances in fish and other seafood with special reference to carcinogenic substances
67. Comparison of uptake of dioxin-like compounds by daged cannel catfish and semipermeable membrane devices in the Saginaw River, Michigan
68. Semi-automated colorimetric and enzymatic assays for aquatic organisms using microplate readers
69. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
70. Reproductive failure in populations of the dog-whelk, Nucella lapillus, caused by imposex induced by tributyltin from antifouling paints
71. Application of an in vitro keratinization assay to extracts of soot from a PCB-containing transformer
72. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan
73. Immunochemical cross-reactivity of β-naphthoflavone-inducible cytochrome P450 (P450IA) in liver microsomes from different fish species and rat
74. The cytochrome P-450 system in fish, aquatic toxicology and environmental monitoring
75. The mussel watch - A first step in global marine monitoring
76. Effects of ortho and non-ortho substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops)
77. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
78. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms
79. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in vascular endothelium with toxicity in early life stages of lake trout
80. Caged and wild fish: Induction of hepatic cytochrome P-450 (CYP1A1) as an environmental monitor
81. Cytochrome P450 induction and inhibition by planar halogenated aromatic hydrocarbons in a fish cell line: Promise and pitfalls for environmental testing
82. Overestimation of toxic equivalency factors (TEFs) resulting from inhibition of EROD activity by cytochrome P450 1A inducers in cultured cells
83. The aryl hydrocarbon receptor: A comparative perspective
84. Mechanisms of innate and acquired resistance to dioxin-like compounds
85. The Ah receptor in marine animals: Phylogenetic distribution and relationship to P4501A inducibility
86. Cytochrome P4501A induction and inhibition by 3,3′,4,4′-tetrachlorobiphenyl in an Ah receptor-containing fish hepatoma cell line (PLHC-1)
87. Photoaffinity labeling of the Ah receptor: Phylogenetic survey of diverse vertebrate and invertebrate species
88. Rapid assessment of induced cytochrome P4501A (CYP1A) protein and catalytic activity in fish hepatoma cells grown in multi-well plates: Response to TCDD, TCDF, and two planar PCBs
89. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family
90. Aryl hydrocarbon receptor function in early vertebrates: Inducibility of cytochrome P4501A in agnathan and elasmobranch fish
91. Swedish dioxin survey: Evaluation of the H-4-II E bioassay for screening environmental samples for dioxin-like enzyme induction
92. The aryl hydrocarbon receptor complex
93. Stepping backward to improve assessment of PCB congener toxicities
94. Feminization in common terns (Sterna hirundo): Relationship to dioxin equivalents and estrogenic compounds
95. Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations
96. The use of biological markers in toxicology
97. Quantification of CYP1A1 and 2B1/2 in rat hepatocytes cultured in microwells by immunological methods
98. Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays
99. Screening assay for dioxin-like compounds based on competitive binding to the murine hepatic Ah receptor. 2. Application to environmental samples
100. Semipermeable membrane devices (SPMDs) for the concentration and assessment of bioavailable organic contaminants in aquatic environments
101. A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts
102. Induction of CYP1A and porphyrin accumulation in fish hepatoma cells (PLHC-1) exposed to sediment or water from a PCB-contaminated lake (Lake Kernaala, Finland)
103. Comparison of two bioassays, a fish liver cell line (PLHC-1) and a midge (Chironomus riparius), in monitoring freshwater sediments
104. Relative potencies of PAHs and PCBs based on the response of human cells
105. 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA
106. Accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North-American Great-Lakes
107. Cytochromes P450 induction by nitrated polycyclic aromatic hydrocarbons, azaarenes, and binary mixtures in fish hepatoma cell line PLHC-1
108. A rapid and sensitive cell culture bioassay for measuring ethoxyresorufin-o-deethylase (EROD) activity in cultured hepatocytes exposed to halogenated aromatic hydrocarbons extracted from wild bird eggs
109. Ethoxyresorufin-o-deethylase and porphyrin analysis in chicken embryo hepatocyte cultures with a fluorescence multi-well plate reader
110. Efficient analysis of cytochrome P4501A catalytic activity, porphyrins, and total proteins in chicken embryo hepatocyte cultures with a fluorescence plate reader
111. Chicken embryo hepatocyte bioassay for measuring cytochrome P4501A-based 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in environmental samples
112. Consumption of fish: Benefits and perceived risk
113. Inducibility of a molecular bioreporter system by heavy metals
114. Chemical and biological 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fly ash from combustion of bleached kraft pulp mill sludge
115. Comparisons of patterns of polychlorinated biphenyl congeners in water, sediment, and indiginous organisms from New Bedford harbor, Massachusetts
116. Reproductive success, developmental anomalies, and environmental contaminants in double-crested cormorants (Phalacrocorax auritus)
117. Bioaccumulation of organochlorines by yearling coho salmon (Oncorhynchus kisutch walbaum) fed diets containing Great Lakes' coho salmon, and the pathophysiological responses of the recipients
118. Immunoquantitation and microsomal monooxygenase activities of hepatic cytochromes P4501A and p4502B and chlorinated hydrocarbon contaminant levels in polar bear (Ursus maritimus)
119. Apparent induction of a cytochrome P450 with immunochemical similarities to CYP1A in digestive gland of the common mussel (Mytilus galloprovincialis L.) with exposure to 2,2′,3,4,4′,5′-hexachlorobiphenyl and Aroclor 1254
120. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health
121. Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans
122. New molecular endpoints and methods for routine toxicity testing
123. Toxic chemicals in marine sediment and biota from Mukilteo, Washington: Relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus)
124. Tetrazolium-based cell bioassay for neurotoxins active on voltage-sensitive sodium channels: Semiautomated assay for saxitoxins, brevitoxins, and ciguatoxins
125. Detection of sodium channel toxins: Directed cytotoxicity of purified ciguatoxins, brevitoxins, saxitoxins and seafood extracts
126. Alkylmercury species in the equatorial Pacific
127. A review of the Food and Drug Administration risk analysis for polychlorinated biphenyls in fish
128. Functional toxicology: A new approach to detect biologically active xenobiotics
129. Expression of CYP1A1 gene in patients with lung cancer: Evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas
130. Carcinogenic and genotoxic activity of extracts from contaminated sediments in western Lake Ontario
131. Oil refinery effluents: Evidence of cocarcinogenic activity in the trout embryo microinjection assay
132. Organochlorine contaminants in arctic food chains: Accumulation of specific polychlorinated biphenyls and chlordane-related compounds
133. Epizootic carcinoma in the winter flounder, Pseudopleuronectes americanus
134. Chemical-activated luciferase gene expression (CALUX): A novel in vitro bioassay for the Ah receptor active compounds in sediments and pore water
135. The CALUX (chemical-activated luciferase expression) assay adapted and validated for measuring TCDD equivalents in blood plasma
136. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of Ah receptor agonists
137. Hazard analysis and critical control point principles and application guidelines
138. Pharmacogenetics: An approach to understanding chemical and biologic aspects of cancer
139. The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
140. Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
141. Induction of aryl hydrocarbon hydroxylase activity in various cell cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin
142. Chlorinated hydrocarbon contaminants in arctic marine mammals
143. A gel-permeation/column chromatography cleanup method for the determination of CDDs in animal tissue
144. Organochlorine contaminants in arctic marine food chains: Identification, geographical distribution, and temporal trends in polar bears
145. Dibenzofurans a greater global pollutant then dioxins? Evidence from analyses of open ocean killer whale
146. Mixed-function oxygenases in biological monitoring programs: Review of potential usage in different phyla of aquatic animals
147. Marine pollution
148. A review of monitoring strategies and assessments of estuarine pollution
149. Environment and cancer: Who are susceptible?
150. Analysis of non-ortho-PCBs in fish, bird eggs, sediments, soils, and SPMD samples by gas chromatography/high resolution mass spectrometry
151. Competitive inhibition by inducer as a confounding factor in the use of the ethoxyresorufin-o-deethylase (EROD) assay to estimate exposure to dioxin-like compounds
152. Innovative techniques for harmful algal toxin analysis
153. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methyl-cholanthrene
154. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
155. Neurotoxic shellfish poisoning and brevetoxin metabolites: A case study from Florida
156. Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons
157. Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs
158. Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator
159. Identification of polychlorinated dibenzofurans in environmental samples
160. Use of mixed function oxygenases to monitor contaminant exposure in wildlife
161. Relation among cytochrome P450, AH-active PCB congeners, and dioxin equivalents in pipping black-crowned night-heron embryos
162. Reproductive failure in common seals feeding on fish from polluted coastal waters
163. Risk assessment, risk management, and fish consumption advisories in the United States
164. An in vitro rainbow trout cell bioassay for aryl hydrocarbon receptor-mediated toxins
165. 2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene-comparative studies of Ah receptor binding, transformation, and induction of Cyp1A1
166. Transfer of chlorinated biphenyls to Antarctica
167. Recombinant cell bioassays for endocrine disruptors: Development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals
168. Aryl hydrocarbon receptor-mediated signal transduction
169. Polychlorinated biphenyls: Congener-specific analysis of a commercial mixture and human milk extract
170. Determination of 2,3,7,8-TCDD toxic equivalent factors (TEFs): Support for the use of in the vitro AHH induction assay
171. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
172. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: Implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons
173. PCB isomers and congeners: Induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells
174. Oxidative inactivation of cytochrome P450 1A (CYP1A) stimulated by 3,3′,4,4′-tetrachlorobiphenyl: Production of reactive oxygen by vertebrate CYP1As
175. 3,3′,4,4′-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: Relationship to cytochrome P450 1A inactivation and reactive oxygen production
176. Ah receptor signaling pathways
177. Screening assay for dioxin-like compounds based on competitive binding to the murine hepatic Ah receptor. 1. Assay development
178. Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes
179. Ah receptor-based chemical screening bioassays: Application and limitations for the detection of Ah receptor agonists
180. Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate
181. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes
182. Embryonic mortality, bioassay-derived 2,3,7,8-tetrachlorodibenao-p-dioxin equivalents, and organochlorine contaminants in pacific salmon from lake Ontario
183. Molecular responses to environmental contamination: Enzyme and protein systems as indicators of contaminant exposure and effect
184. Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species
185. Monooxygenase induction and chlorobiphenyls in the deep-sea fish Coryphaenoides armatus
186. Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart
187. Cytochrome P450 1A expression in mid-water fishes: Potential effects of organic chemical contaminants in remote oceanic zones
188. Development of a highly sensitive enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of polychlorinated dibenzo-p-dioxins
189. Effects induced by feeding organochlorine-contaminated carp from Saginaw Bay, Lake Huron, to laying white leghorn hens. II. Embryotoxic and teratogenic effects
190. Exposure to dioxins and dibenzofurans through the consumption of fish
191. Human health consequences of consumption of fish contaminated with organochlorine compounds
192. The AH-receptor - Genetics, structure and function
193. Rapid assays for environmental and biological monitoring
194. Method for the determination of three toxic non-ortho chlorine substituted coplanar PCBs in environmental samples at part-per-trillion levels
195. Chemical modernization and vulnerability of cetaceans: Increasing toxic threat of organochlorine contaminants
196. Health advisories for consumers of great lakes sport fish: Is the message being received?
197. Dioxinlike components in incinerator fly ash: A comparison between chemical analysis data and results from a cell culture bioassay
198. H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes
199. Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples
200. Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes
201. Dietary exposure of mink to carp from Saginaw Bay.3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification
202. Exposure to polychlorinated biphenyls causes endothelial cell dysfunction
203. The CAT-Tox (L) assay: A sensitive and specific measure of stress-induced transcription in transformed human liver cells
204. Induction of aryl hydrocarbon hydroxylase activity in cell cultures by aroclors, residues from Yusho oil samples, and polychlorinated biphenyl residues from fish samples
205. A toxic equivalency factor scale for polychlorinated dibenzofurans
206. Toxic equivalency factors (TEFs) for PCBs, PCDDs, and PCDFs for humans and wildlife
207. Survey of receiving water environmental impacts associated with discharges from pulp mills. IV. Bioassay derived 2,3,7,8-TCDD toxic equivalent concentrations in white sucker (Catostomus commersoni) in relation to biochemical indicators of impact
208. Development of rapid and sensitive high throughput pharmacologic assays for marine phyctoxins
209. CYP1A mRNA levels as a human exposure biomarker: Use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes
210. A fluorescent microplate assay for diarrheic shellfish toxins
211. Aryl hydrocarbon receptor-mediated toxic potency of dissolved lipophilic organic contaminants collected from Lincoln Creek, Milwaukee, Wisconsin, USA, to PLHC-1 (Poeciliopsis lucida) fish hepatoma cells
212. In vitro response of fish and mammalian cells to complex mixtures of polychlorinated naphthalenes, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons
213. Potency of a complex mixture of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin in causing fish early life stage mortality
214. PCB contamination in and around New Bedford, Mass
215. Toxicity and bioaccumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin in long term tests with the freshwater benthic invertebrates Chironomus tentans and Lumbriculus variegatus
216. Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whales (Delphinapterus leucas)
217. Mechanistic aspects of dioxin action
218. Mammalian and teleost cell line bioassay and chemically derived tcdd -equivalent concentrations in lake trout (Salvelinus namaycush) from Lake Superior and Lake Ontario, North America
219. Bioassay for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEs) in human hepatoma HepG2 cells
220. Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs)
221. Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene
222. Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in eggs of double-crested cormorants from a colony near Green Bay, Wisconsin, USA
223. Rainbow trout embryotoxicity of a complex contaminant mixture extracted from Lake Michigan Lake Trout
224. Nondetectable concentrations of human placental Ah receptors are associated with potent induction of microsomal benzo[a]pyrene hydroxylase in individuals exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans
225. DNA sequence determinants for binding of transformed Ah-receptor to a dioxin-responsive enhancer
226. Relative potencies of individual polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners and congener mixtures based on induction of cytochrome P4501A mRNA in a rainbow trout gonadal cell line (RTG-2)
227. In vitro bioassays for assessing estrogenic substances
228. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in vitro enzyme induction activities
229. Detection of estrogen- and dioxin-like activity in pulp and paper mill black liquor and effluent using in vitro recombinant receptor/reporter gene assays
230. Application of enzyme-linked immunosorbent assay (ELISA) for measurement of polychlorinated biphenyls (PCBs) from hydrophobic solutions: Extracts of fish and dialysates of semipermeable membrane devices (SPMDs)
231. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum