Cutting edge: Activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 +CD25+ cells with characteristics of regulatory T cells

Journal of Immunology

Volumn 175, Issue 7, 2005, Pages 4184-4188

  Funatake, Castle J ^a   Marshall, Nikki B ^a,b   Steppan, Linda B ^a   Mourich, Dan V ^a,b   Kerkvliet, Nancy I ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b AVI BIOPHARMA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID; INTERLEUKIN 2 RECEPTOR ALPHA; LIGAND; PADGEM PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; GRAFT VERSUS HOST REACTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOREGULATION; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL;

EID: 25444526629     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.7.4184     Document Type: Article

References (33)

1. Schmidt, J. V., and C. A. Bradfield. 1996. Ah receptor signaling pathways. Annu. Rev. Cell. Dev. Biol. 12:55-89.
2. Gu, Y.-Z., J. B. Hogenesch, and C. A. Bradfield. 2000. The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40: 519-561.
3. Denison, M. S., and S. R. Nagy. 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43: 309-334.
4. Ciolino, H. P., P. J. Daschner, and G. C. Yeh. 1999. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. Biochem. J. 340:715-722.
5. Ema, M., N. Ohe, M. Suzuki, J. Mimura, K. Sogawa, S. Ikawa, and Y. Fujii-Kuriyama. 1994. Dioxin binding activities of polymorphic forms of mouse and human aryl hydrocarbon receptors. J. Biol. Chem. 269: 27337-27343.
6. Kerkvliet, N. I. 2002. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int. Immunopharmacol. 2: 277-291.
7. Weisglas-Kuperus, N., S. Patandin, G. A. Berbers, T. C. Sas, P. G. Mulder, P. J. Sauer, and H. Hooijkaas. 2000. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ. Health Perspect. 108: 1205-1207.
8. Tonn, T., C. Esser, E. M. Schneider, W. Steinmann-Steiner-Haldenstatt, and E. Gleichmann. 1996. Persistence of decreased T-helper cell function in industrial workers 20 years after exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin. Environ. Health Perspect. 104: 422-426.
9. Vorderstrasse, B. A., L. B. Steppan, A. E. Silverstone, and N. I. Kerkvliet. 2001. Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Toxicol. Appl. Pharmacol. 171: 157-164.
10. + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD. Toxicol. Appl. Pharmacol. 185: 146-152.
11. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3: 253-257.
12. Funatake, C. J., E. A. Dearstyne, L. B. Steppan, D. M. Shepherd, E. S. Spanjaard, A. Marshak-Rothstein, and N. I. Kerkvliet. 2004. Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. Toxicol. Sci. 82: 129-142.
13. Kruisbeek, A. M., E. M. Shevach, and A. M. Thornton. 2004. Proliferative assays for T cell function. In Current Protocols in Immunology, Vol. 1. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Wiley, New York, p. 3.12.1.
14. + T cells in adoptively transferred mice. Toxicol. Sci. 56: 340-350.
15. Camacho, I. A., M. Nagarkatti, and P. S. Nagarkatti. 2002. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces Fas-dependent activation-induced cell death in superantigen-primed T cells. Arch. Toxicol. 76: 570-580.
16. Gudmundsdottir, H., A. D. Wells, and L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162: 5212-5223.
17. Demirci, G., W. Gao, X. X. Zheng, T. R. Malek, T. B. Strom, and X. C. Li. 2002. On CD28/CD40 ligand costimulation, common γ-chain signals, and the alloimmune response. J. Immunol. 168: 4382-4390.
18. Maury, S., B. Salomon, D. Klatzmann, and J. L. Cohen. 2001. Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood 98: 3156-3158.
19. Refaeli, Y., L. Van Parijs, C. A. London, J. Tschopp, and A. K. Abbas. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8: 615-623.
20. Schmitz, I., A. Krueger, S. Baumann, H. Schulze-Bergkamen, P. H. Krammer, and S. Kirchhoff. 2003. An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death. J. Immunol. 171: 2930-2936.
21. + regulatory T cells protects from lethal acute GVHD. Blood 105:2220-2226.
22. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196: 401-406.
23. Takahashi, T., and S. Sakaguchi. 2003. The role of regulatory T cells in controlling immunologic self-tolerance. Int. Rev. Cytol. 225: 1-32.
24. Prell, R. A., E. Dearstyne, L. G. Steppan, A. T. Vella, and N. I. Kerkvliet. 2000. CTL hyporesponsiveness induced by 2,3,7, 8-tetrachlorodibenzo- p-dioxin: role of cytokines and apoptosis. Toxicol. Appl. Pharmacol. 166: 214-221.
25. Oughton, J. A., and N. I. Kerkvliet. 1999. Novel phenotype associated with in vivo activated CTL precursors. Clin. Immunol. 90: 323-333.
26. Kerkvliet, N. I., L. Baecher-Steppan, D. M. Shepherd, J. A. Oughton, B. A. Vorderstrasse, and G. K. DeKrey. 1996. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 157: 2310-2319.
27. Prell, R. A., and N. I. Kerkvliet. 1997. Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma. J. Immunol. 158: 2695-2703.
28. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99: 3493-3499.
29. + regulatory T cells. J. Immunol. 172: 5986-5993.
30. + regulatory T cells. Int. Immunol. 16: 1189-1201.
31. + regulatory T cell function. J. Exp. Med. 196: 851-857.
32. Nelson, B. H. 2004. IL-2, regulatory T cells, and tolerance. J. Immunol. 172: 3983-3988.
33. Jeon, M. S., and C. Esser. 2000. The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionary conserved bHLH-PAS transcription factor family. J. Immunol. 165: 6975-6983.