Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation

Toxicology Letters

Volumn 177, Issue 2, 2008, Pages 130-137

  Podechard, Normand ^a   Lecureur, Valérie ^a   Le Ferrec, Eric ^a   Guenon, Isabelle ^a   Sparfel, Lydie ^a   Gilot, David ^a   Gordon, John R ^c   Lagente, Vincent ^a   Fardel, Olivier ^a,b  

^a INSERM   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Aryl hydrocarbon receptor; Benzo(a)pyrene; CXCR2; Inflammation; Interleukin 8; Macrophage

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CHEMOATTRACTANT; CHEMOKINE RECEPTOR ANTAGONIST; INTERLEUKIN 8; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; KERATINOCYTE; LUNG LAVAGE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; RNA INTERFERENCE; UPREGULATION; XENOBIOTIC METABOLISM;

ANIMALS; BENZO(A)PYRENE; BRONCHOALVEOLAR LAVAGE FLUID; CELL MOVEMENT; CHEMOTACTIC FACTORS; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENVIRONMENTAL POLLUTANTS; HUMANS; INTERLEUKIN-8; KERATINOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; NEUTROPHILS; PNEUMONIA; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, INTERLEUKIN-8B; RESPONSE ELEMENTS; RNA INTERFERENCE; UP-REGULATION;

MURINAE; MUS;

EID: 39949085215     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.01.006     Document Type: Article

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