-
1
-
-
0025304539
-
Rheumatoid arthritis. Pathophysiology and implications for therapy
-
Harris ED, Jr. (1990) Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 322:1277-1289.
-
(1990)
N Engl J Med
, vol.322
, pp. 1277-1289
-
-
Harris Jr., E.D.1
-
2
-
-
0033524159
-
Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
-
ATTRACT Study Group
-
Maini R, et al.; ATTRACT Study Group (1999) Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial. Lancet 354:1932-1939.
-
(1999)
Lancet
, vol.354
, pp. 1932-1939
-
-
Maini, R.1
-
3
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
DOI 10.1056/NEJM199901283400401
-
Weinblatt ME, et al. (1999) A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340:253-259. (Pubitemid 29063266)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.4
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
Bulpitt, K.J.4
Fleischmann, R.M.5
Fox, R.I.6
Jackson, C.G.7
Lange, M.8
Burge, D.J.9
-
4
-
-
0037231533
-
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
-
DOI 10.1002/art.10697
-
Weinblatt ME, et al. (2003) Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum 48:35-45. (Pubitemid 36091645)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.1
, pp. 35-45
-
-
Weinblatt, M.E.1
Keystone, E.C.2
Furst, D.E.3
Moreland, L.W.4
Weisman, M.H.5
Birbara, C.A.6
Teoh, L.A.7
Fischkoff, S.A.8
Chartash, E.K.9
-
5
-
-
77950263939
-
Review of tocilizumab in the treatment of rheumatoid arthritis
-
Okuda Y (2008) Review of tocilizumab in the treatment of rheumatoid arthritis. Biologics 2:75-82.
-
(2008)
Biologics
, vol.2
, pp. 75-82
-
-
Okuda, Y.1
-
6
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, et al. (2008) IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 67:1516-1523.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1516-1523
-
-
Emery, P.1
-
7
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
-
OPTION Investigators
-
Smolen JS, et al.; OPTION Investigators (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 371:987-997.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
-
8
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
DOI 10.1084/jem.20041257
-
Langrish CL, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-240. (Pubitemid 40189432)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.2
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
9
-
-
27544490377
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
DOI 10.1038/ni1254, PII N1254
-
Harrington LE, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132. (Pubitemid 41541790)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
Weaver, C.T.7
-
10
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
DOI 10.1038/ni1261, PII N1261
-
Park H, et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6:1133-1141. (Pubitemid 41541791)
-
(2005)
Nature Immunology
, vol.6
, Issue.11
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
Wang, Y.-H.6
Wang, Y.7
Hood, L.8
Zhu, Z.9
Tian, Q.10
Dong, C.11
-
11
-
-
0038623916
-
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
-
DOI 10.1073/pnas.1035999100
-
Nakae S, et al. (2003) IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 100:5986-5990. (Pubitemid 36576918)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.10
, pp. 5986-5990
-
-
Nakae, S.1
Saijo, S.2
Horai, R.3
Sudo, K.4
Mori, S.5
Iwakura, Y.6
-
12
-
-
33846456970
-
+ Th cells that cause autoimmune arthritis
-
DOI 10.1084/jem.20062259
-
Hirota K, et al. (2007) T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204:41-47. (Pubitemid 46148754)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.1
, pp. 41-47
-
-
Hirota, K.1
Hashimoto, M.2
Yoshitomi, H.3
Tanaka, S.4
Nomura, T.5
Yamaguchi, T.6
Iwakura, Y.7
Sakaguchi, N.8
Sakaguchi, S.9
-
13
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
14
-
-
34548125305
-
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
-
DOI 10.1038/ni1496, PII NI1496
-
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8:942-949. (Pubitemid 47300008)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavecchia, A.3
Sallusto, F.4
-
15
-
-
57349083145
-
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
-
Fujimoto M, et al. (2008) Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum 58:3710-3719.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3710-3719
-
-
Fujimoto, M.1
-
16
-
-
40549102753
-
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase
-
DOI 10.1002/art.23222
-
Iwanami K, et al. (2008) Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum 58:754-763. (Pubitemid 351364873)
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.3
, pp. 754-763
-
-
Iwanami, K.1
Matsumoto, I.2
Tanaka-Watanabe, Y.3
Inoue, A.4
Mihara, M.5
Ohsugi, Y.6
Mamura, M.7
Goto, D.8
Ito, S.9
Tsutsumi, A.10
Kishimoto, T.11
Sumida, T.12
-
17
-
-
0020329644
-
Collagen arthritis as a relevant model for rheumatoid arthritis
-
Trentham DE (1982) Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum 25:911-916.
-
(1982)
Arthritis Rheum
, vol.25
, pp. 911-916
-
-
Trentham, D.E.1
-
19
-
-
0026600294
-
Induction of arthritis with monoclonal antibodies to collagen
-
Terato K, et al. (1992) Induction of arthritis with monoclonal antibodies to collagen. J Immunol 148:2103-2108.
-
(1992)
J Immunol
, vol.148
, pp. 2103-2108
-
-
Terato, K.1
-
20
-
-
0026725943
-
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
-
Burbach KM, Poland A, Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89:8185-8189.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8185-8189
-
-
Burbach, K.M.1
Poland, A.2
Bradfield, C.A.3
-
21
-
-
0026749010
-
cDNA cloning and structure of mouse putative Ah receptor
-
Ema M, et al. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184:246-253.
-
(1992)
Biochem Biophys Res Commun
, vol.184
, pp. 246-253
-
-
Ema, M.1
-
22
-
-
0028017377
-
Ah receptor: A novel ligand-activated transcription factor
-
Fujii-Kuriyama Y, Ema M, Mimura J, Sogawa K (1994) Ah receptor: A novel ligand-activated transcription factor. Exp Clin Immunogenet 11:65-74. (Pubitemid 24305626)
-
(1994)
Experimental and Clinical Immunogenetics
, vol.11
, Issue.2-3
, pp. 65-74
-
-
Fujii-Kuriyama, Y.1
Ema, M.2
Mimura, J.3
Sogawa, K.4
-
24
-
-
42649095378
-
H17 cell differentiation by the aryl hydrocarbon receptor
-
DOI 10.1038/nature06880, PII NATURE06880
-
Quintana FJ, et al. (2008) Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453:65-71. (Pubitemid 351630328)
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
Korn, T.4
Farez, M.F.5
Bettelli, E.6
Caccamo, M.7
Oukka, M.8
Weiner, H.L.9
-
25
-
-
47749107262
-
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
-
DOI 10.1073/pnas.0804231105
-
Kimura A, Naka T, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2008) Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci USA 105:9721-9726. (Pubitemid 352031367)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.28
, pp. 9721-9726
-
-
Kimura, A.1
Naka, T.2
Nohara, K.3
Fujii-Kuriyama, Y.4
Kishimoto, T.5
-
26
-
-
42649106556
-
H17-cell-mediated autoimmunity to environmental toxins
-
DOI 10.1038/nature06881, PII NATURE06881
-
Veldhoen M, et al. (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:106-109. (Pubitemid 351630329)
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 106-109
-
-
Veldhoen, M.1
Hirota, K.2
Westendorf, A.M.3
Buer, J.4
Dumoutier, L.5
Renauld, J.-C.6
Stockinger, B.7
-
27
-
-
69549126213
-
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses
-
Kimura A, et al. (2009) Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med 206:2027-2035.
-
(2009)
J Exp Med
, vol.206
, pp. 2027-2035
-
-
Kimura, A.1
-
28
-
-
0019512029
-
Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates
-
DOI 10.1084/jem.154.3.688
-
Wooley PH, Luthra HS, Stuart JM, David CS (1981) Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med 154:688-700. (Pubitemid 11060781)
-
(1981)
Journal of Experimental Medicine
, vol.154
, Issue.3
, pp. 688-700
-
-
Wooley, P.H.1
Luthra, H.S.2
Stuart, J.M.3
David, C.S.4
-
29
-
-
77955839399
-
A multiparameter approach to monitor disease activity in collagen-induced arthritis
-
10.1186/ar3119
-
Seeuws S, et al. (2010) A multiparameter approach to monitor disease activity in collagen-induced arthritis. Arthritis Res Ther 12:R160 10.1186/ar3119.
-
(2010)
Arthritis Res Ther
, vol.12
-
-
Seeuws, S.1
-
30
-
-
0029154908
-
Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis
-
Yoshihara Y, et al. (1995) Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis. Arthritis Rheum 38:969-975.
-
(1995)
Arthritis Rheum
, vol.38
, pp. 969-975
-
-
Yoshihara, Y.1
-
31
-
-
84862644604
-
The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis
-
10.1007/s00296-010-1710-0
-
Wang W, et al. (2011) The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int 10.1007/s00296-010-1710-0.
-
(2011)
Rheumatol Int
-
-
Wang, W.1
-
32
-
-
46749125294
-
Shifting the imbalance from Th1/Th2 to Th17/treg: The changing rheumatoid arthritis paradigm
-
Boissier MC, Assier E, Falgarone G, Bessis N (2008) Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine 75:373-375.
-
(2008)
Joint Bone Spine
, vol.75
, pp. 373-375
-
-
Boissier, M.C.1
Assier, E.2
Falgarone, G.3
Bessis, N.4
-
33
-
-
77955655540
-
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice
-
Takamura T, et al. (2010) Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunol Cell Biol 88:685-689.
-
(2010)
Immunol Cell Biol
, vol.88
, pp. 685-689
-
-
Takamura, T.1
-
34
-
-
71949098229
-
Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock
-
Sekine H, et al. (2009) Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol 29:6391-6400.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6391-6400
-
-
Sekine, H.1
-
35
-
-
50849119107
-
A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis
-
Kobayashi S, et al. (2008) A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. Rheumatology (Oxford) 47:1317-1322.
-
(2008)
Rheumatology (Oxford)
, vol.47
, pp. 1317-1322
-
-
Kobayashi, S.1
-
36
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
DOI 10.1038/nri2094, PII NRI2094
-
McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-442. (Pubitemid 46834849)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.6
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
37
-
-
75649140602
-
Regulation of pathogenic IL-17 responses in collagen-induced arthritis: Roles of endogenous interferon-gamma and IL-4
-
Sarkar S, et al. (2009) Regulation of pathogenic IL-17 responses in collagen-induced arthritis: Roles of endogenous interferon-gamma and IL-4. Arthritis Res Ther 11:R158.
-
(2009)
Arthritis Res Ther
, vol.11
-
-
Sarkar, S.1
-
38
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511. (Pubitemid 38931765)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.7
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
39
-
-
78650560167
-
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
-
Nguyen NT, et al. (2010) Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Proc Natl Acad Sci USA 107:19961-19966.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 19961-19966
-
-
Nguyen, N.T.1
-
40
-
-
34250162097
-
Collagen-induced arthritis
-
DOI 10.1038/nprot.2007.173, PII NPROT.2007.173
-
Brand DD, Latham KA, Rosloniec EF (2007) Collagen-induced arthritis. Nat Protoc 2:1269-1275. (Pubitemid 46901304)
-
(2007)
Nature Protocols
, vol.2
, Issue.5
, pp. 1269-1275
-
-
Brand, D.D.1
Latham, K.A.2
Rosloniec, E.F.3
-
41
-
-
55849095891
-
Evidence that cytokines play a role in rheumatoid arthritis
-
Brennan FM, McInnes IB (2008) Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118:3537-3545.
-
(2008)
J Clin Invest
, vol.118
, pp. 3537-3545
-
-
Brennan, F.M.1
McInnes, I.B.2
-
42
-
-
0034081170
-
b) mice: New insights into an important disease model of rheumatoid arthritis
-
DOI 10.1002/1521-4141(200006)30:6<1568::AID-IMMU1568>3.0.CO;2-R
-
Campbell IK, Hamilton JA, Wicks IP (2000) Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 30:1568-1575. (Pubitemid 30342798)
-
(2000)
European Journal of Immunology
, vol.30
, Issue.6
, pp. 1568-1575
-
-
Campbell, I.K.1
Hamilton, J.A.2
Wicks, L.P.3
|